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Total 994 results found since Jan 2013.
Effects of an Avocado-based Mediterranean Diet on Serum Lipids for Secondary Prevention after Ischemic Stroke Trial (ADD-SPISE): Study protocol
Conclusion:
We hypothesize that an Avocado-based Mediterranean diet will further reduce the levels of LDL-cholesterol at 3 months compared to the control diet, and that the intervention is safe and feasible.
Registration:
The study is registered under ADDSPISE at www.clinicaltrials.gov. Identifier NCT03524742. Protocol ID CAS-605 version 3.0 (May 2nd, 2019).
Source: Medicine - June 18, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Intracardiac thrombus in a patient with mitral bioprosthesis and atrial fibrillation treated with direct oral anticoaugulant: A case report
Rationale:
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with increased morbidity, especially stroke and heart failure. There is also increasing awareness that atrial fibrillation is a major cause of embolic events which in 75% of cases are complicated by cerebrovascular accidents.
Patient concerns:
A 50-year-old woman with mitral bioprosthesis under warfarin for nonvalvular atrial fibrillation was referred to our Coronary Intensive Care Unit due to acute myocardial infarction without evidence of significant coronary artery stenosis.
Diagnoses:
Cardiovascular examination...
Source: Medicine - June 11, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Meningioma preceding CASPR2 antibody limbic encephalitis with a stroke mimic: A case report
We report a contactin-associated protein-like 2-antibody (CASPR2-Ab)-positive patient who presented with atypical LE.
Diagnoses:
CASPR2-Ab-positive LE was the presumed diagnosis. Re-evaluation of cerebrospinal fluid (CSF) samples revealed autoantibodies targeting CASPR2 at an immunoglobulin G titer of 1:1. The clinical presentation of subacute onset seizures, abnormal electroencephalography, hypermetabolism on positron emission tomography, good immunotherapy response, and the presence of specific antibodies in serum supports a diagnosis of autoimmune LE.
Intervention:
The patient received glucocorticoids (1â€...
Source: Medicine - June 11, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Effects of brain-computer interface training on upper limb function recovery in stroke patients: A protocol for systematic review and meta-analysis
Conclusion:
Our study will provide reliable evidence for the effect of BCI technology on the improvement of upper limb function in stroke patients.
PROSPERO registration number:
CRD42021250378.
Source: Medicine - June 11, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Off-label reduced-dose apixaban does not reduce hemorrhagic risk in Taiwanese patients with nonvalvular atrial fibrillation: A retrospective, observational study
East Asians are reportedly at high risk of anticoagulant-related bleeding; therefore, some physicians prefer to prescribe low-dose direct oral anticoagulants (DOACs). Little is known about the therapeutic effectiveness and safety of off-label reduced-dose apixaban in East Asians with nonvalvular atrial fibrillation (AF). We aimed to investigate the effectiveness and safety of off-label reduced-dose apixaban in Taiwanese patients with nonvalvular AF.
This retrospective cohort study enrolled 1073 patients with nonvalvular AF who took apixaban between July 2014 and October 2018 from 4 medical centers in southern Taiwan. Th...
Source: Medicine - June 11, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Abnormal singing can identify patients with right hemisphere cortical strokes at risk for impaired prosody
Despite lacking aphasia seen with left hemisphere (LH) infarcts involving the middle cerebral artery territory, right hemisphere (RH) strokes can result in significant difficulties in affective prosody. These impairments may be more difficult to identify but lead to significant communication problems.
We determine if evaluation of singing can accurately identify stroke patients with cortical RH infarcts at risk for prosodic impairment who may benefit from rehabilitation.
A prospective cohort of 36 patients evaluated with acute ischemic stroke was recruited. Participants underwent an experimental battery evaluating th...
Source: Medicine - June 11, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Comparison between acupuncture and antidepressant therapy for the treatment of poststroke depression: Systematic review and meta-analysis
Conclusions:
The results of this study suggest that acupuncture not only can reduce the severity of PSD, but also has significant effects on decreasing the appearance of other adverse events.
Source: Medicine - June 4, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
The application value of continuous nursing intervention on quality of life in patients with stroke: A protocol for systematic review and meta-analysis
Conclusion:
The present study will summarize the direct and indirect pieces of evidence to ascertain whether continuous nursing intervention can improve the quality of life in patients with stroke.
Ethics and dissemination:
Ethical approval will not be required.
Registration number:
April 25, 2021.osf.io/xnrzt/ (https://osf.io/xnrzt/).
Source: Medicine - June 4, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Herbal medicine for post-stroke insomnia: A protocol for systematic review and meta-analysis
Conclusion:
This study will provide evidence regarding the efficacy and safety of HM for the treatment of PSI.
Ethics and dissemination:
No ethical approval will be needed because data from previously published studies in which informed consent was obtained by primary investigators will be retrieved and analyzed. We will publish this systematic review in a peer-reviewed journal.
OSF registration DOI:
10.17605/OSF.IO/PEHQZ.
Source: Medicine - June 4, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Effects of early mobilization on short-term blood pressure variability in acute intracerebral hemorrhage patients: A protocol for randomized controlled non-inferiority trial
Conclusions:
It is safe to implement the EM protocol within 24 to 72 hour of onset for mild-moderate ICH patients during the acute phase.
Source: Medicine - May 28, 2021 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Clinical characteristics, triggering etiologies, and response of plasmapheresis in thrombotic microangiopathy in Taiwan
This study indicated the spectrum of underlying causes, extra-renal characteristics, and the response to plasmapheresis of patients with TMA in Taiwan. Of note, the poor clinical outcomes of plasmapheresis in patients with TMA might highlight the masked underlying etiology or worse disease condition that should be noticed.
Source: Medicine - May 21, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Tuina plus acupuncture for post-stroke depression: A protocol for systematic review and meta-analysis
Conclusion:
This systematic review will provide evidence to determine whether Tuina plus acupuncture is an effective and safe intervention for patients with post-stroke depression.
Ethics and dissemination:
The protocol of the systematic review does not require ethical approval because it does not involve humans. This article will be published in peer-reviewed journals and presented at relevant conferences.
Systematic review registration:
INPLASY202140098
Source: Medicine - May 21, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Efficacy and safety of ticagrelor monotherapy in patients following percutaneous coronary intervention: A systematic review and meta-analysis
Background:
We aimed to systematically evaluate the efficacy and safety ticagrelor monotherapy following percutaneous coronary intervention.
Methods:
Online databases were searched for relevant studies (published between the years 2015 and 2020) comparing 1-month Dual antiplatelet therapy (DAPT) followed by 23-month ticagrelor monotherapy with 12-month DAPT followed by 12-month aspirin monotherapy following percutaneous coronary intervention. Primary outcomes assessed efficacy whereas secondary outcomes assessed safety. Odds ratios (OR) with 95% confidence intervals (CIs) based on a random effect model were calc...
Source: Medicine - May 21, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Predictors of bleeding event among elderly patients with mechanical valve replacement using random forest model: A retrospective study
Available classification tools and risk factors predicting bleeding events in elderly patients after mechanical valve replacement may not be suitable in Asian populations. Thus, we aimed to identify an accurate model for predicting bleeding in elderly patients receiving warfarin after mechanical valve replacement in a Korean population. In this retrospective cohort study, a random forest model was used to determine factors predicting bleeding events among 598 participants. Twenty-two descriptors were selected as predictors for bleeding. Steroid use was the most important predictor of bleeding events, followed by labile int...
Source: Medicine - May 14, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Study on optimization and evaluation system of traditional Chinese medicine rehabilitation program for swallowing disorder after stroke
This article presents a study protocol for a multicenter, randomized, controlled trial for evaluating the efficacy of acupuncture in treating post-stroke dysphagia.
Methods/design:
A randomized controlled trial will be conducted in three hospitals in Heilongjiang, Changchun, and Beijing. A total of 252 patients with post-stroke swallowing ability will be randomly divided into two groups; specifically, the experimental group, which will receive acupuncture treatment, and the control group, which will undergo rehabilitation training for 2 weeks. The main results will be evaluated using the standard swallowing function...
Source: Medicine - May 14, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
