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Source: Journal of Neurology
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Total 399 results found since Jan 2013.
Correction to: Neurological update: use of cardiac troponin in patients with stroke
The original article can be found online.
Source: Journal of Neurology - February 25, 2021 Category: Neurology Source Type: research
Trazodone improves obstructive sleep apnea after ischemic stroke: a randomized, double-blind, placebo-controlled, crossover pilot study
ConclusionsObstructive sleep apnea with comorbid ischemic stroke may be a distinctive phenotype which responds quite well to trazodone, decreasing OSA severity without increasing nocturnal hypoxia.Trial RegistrationClinicaltrials.gov: NCT04162743, 2019/11/10.
Source: Journal of Neurology - February 24, 2021 Category: Neurology Source Type: research
Risk of intracranial hemorrhage with direct oral anticoagulants: a systematic review and meta-analysis of randomized controlled trials
ConclusionAll DOACs had a lower risk of ICH than VKAs. In terms of the risk of ICH, DOACs were overall as safe as LMWHs, and apixaban and dabigatran were as safe as aspirin, but rivaroxaban was not. For secondary prevention stroke, the risk of ICH with DOACs was overall lower than warfarin and similar to aspirin, but it should be noted that compared with aspirin, rivaroxaban may increase the risk of ICH. This is the first pair-wise meta-analysis that compares the risk of ICH between DOACs and other antithrombotic drugs in detail across all diseases, which may have certain significance for patients with high risk of ICH to ...
Source: Journal of Neurology - February 17, 2021 Category: Neurology Source Type: research
Effect of transcranial direct current stimulation on post-stroke fatigue
ConclusionA single session of anodal tDCS improves fatigue symptoms with the effect lasting up to a week post stimulation. tDCS may therefore be a useful tool for managing fatigue symptoms post-stroke.Trial registrationNCT04634864Date of registration17/11/2020 –“retrospectively registered”.
Source: Journal of Neurology - February 17, 2021 Category: Neurology Source Type: research
Early recurrent ischemic events after mechanical thrombectomy: effect of post-treatment intracranial hemorrhage
ConclusionsERE occurred in about 4% of patients after MT. PH after MT was associated with delayed initiation of oral anticoagulants and an increased risk of recurrent ischemic events.Clinical trial registrationURL:https://www.clinicaltrials.gov. Unique identifier: NCT02251665.
Source: Journal of Neurology - February 16, 2021 Category: Neurology Source Type: research
Cerebrovascular manifestations in hematological diseases: an update
AbstractPatients with hematological diseases often experience cerebrovascular complications including ischemic stroke, intracerebral and subarachnoid hemorrhage, microbleeds, posterior reversible encephalopathy syndrome, and dural sinus and cerebral vein thrombosis (CVT). In this update, we will review recent advances in the management of cerebrovascular diseases in the context of myeloproliferative neoplasms, leukemias, lymphomas, multiple myeloma, POEMS, paroxysmal nocturnal hemoglobinuria (PNH), thrombotic thrombocytopenic purpura (TTP), and sickle-cell disease. In acute ischemic stroke associated with hematological dis...
Source: Journal of Neurology - February 13, 2021 Category: Neurology Source Type: research
Seizures and epilepsy after intracerebral hemorrhage: an update
AbstractSeizures are common after intracerebral hemorrhage, occurring in 6 –15% of the patients, mostly in the first 72 h. Their incidence reaches 30% when subclinical or non-convulsive seizures are diagnosed by continuous electroencephalogram. Several risk factors for seizures have been described including cortical location of intracerebral hemorrhage, presence of intr aventricular hemorrhage, total hemorrhage volume, and history of alcohol abuse. Seizures after intracerebral hemorrhage may theoretically be harmful as they can lead to sudden blood pressure fluctuations, increased intracranial pressure, and neuronal inj...
Source: Journal of Neurology - February 10, 2021 Category: Neurology Source Type: research
Combined therapy of intensive statin plus intravenous rt-PA in acute ischemic stroke: the INSPIRE randomized clinical trial
ConclusionThe INSPIRE study indicated that intensive statin therapy may not improve clinical outcomes compared with the low dose of statin therapy in AIS patients undergoing intravenous thrombolysis, and the two groups had similar safety profile.Clinical trial registrationURL:http://www.chictr.org. Unique identifier: ChiCTR-IPR-16008642
Source: Journal of Neurology - February 8, 2021 Category: Neurology Source Type: research
Comparison of patients with transient and sustained increments of antiphospholipid antibodies after acute ischemic stroke
ConclusionaPL was rather common in ischemic stroke patients regardless of age. Although the influence of transient positive aPL on ischemic stroke remains uncertain, two or more aPLs and the presence of anti- β2glycoprotein-I IgG may predict a diagnosis of APS.
Source: Journal of Neurology - February 6, 2021 Category: Neurology Source Type: research
Sneddon syndrome: a comprehensive clinical review of 53 patients
ConclusionsSS predominantly affects young women with a relatively large number of cardiovascular risk factors. Clinical features of SS are comparable across different studies. We found no differences in the main clinical features between APL-positive and APL-negative patients.
Source: Journal of Neurology - January 29, 2021 Category: Neurology Source Type: research
Relationship between the degree of recanalization and functional outcome in acute ischemic stroke is mediated by penumbra salvage volume
ConclusionsPSV may be an important mediator between functional outcome and recanalization degree in EVT patients and could serve as a more accurate instrument to compare treatment effects than infarct volumes.
Source: Journal of Neurology - January 24, 2021 Category: Neurology Source Type: research
Contribution of nuclear and mitochondrial gene mutations in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome
ConclusionIndividuals with MELAS exhibit clinical phenotypes with varying degree of severity affecting multiple systems including auditory, visual, cardiovascular, endocrine, and nervous system. This is the first report to show that nuclear genetic factors influence the clinical outcomes/manifestations of MELAS subjects alone or in combination with m.3243A > G mutation.
Source: Journal of Neurology - January 23, 2021 Category: Neurology Source Type: research
Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19)
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, is responsible for the outbreak of coronavirus disease 19 (COVID-19) and was first identified in Wuhan, China in December 2019. It is evident that the COVID-19 pandemic has become a challenging world issue. Although most COVID-19 patients primarily develop respiratory symptoms, an increasing number of neurological symptoms and manifestations associated with COVID-19 have been observed. In this narrative review, we elaborate on proposed neurotropic mechanisms and various neurological symptoms, manifestations, and complications of COVI...
Source: Journal of Neurology - January 23, 2021 Category: Neurology Source Type: research
Central and peripheral nervous system complications of COVID-19: a prospective tertiary center cohort with 3-month follow-up
ConclusionCNS and PNS complications were common in hospitalized COVID-19 patients, particularly in the ICU, and often attributable to critical illness. When COVID-19 was the primary cause for neurological disease, no signs of viral neurotropism were detected, but laboratory changes suggested autoimmune-mediate d mechanisms.
Source: Journal of Neurology - January 13, 2021 Category: Neurology Source Type: research
Long-term psychosocial outcome following mild traumatic brain injury and minor stroke: a direct longitudinal comparison
ConclusionsPsychosocial outcome is largely comparable following mTBI and minor stroke. Specific attention should be paid to anxiety symptoms and cognitive problems in daily life for which uniform aftercare seems appropriate.
Source: Journal of Neurology - January 13, 2021 Category: Neurology Source Type: research
