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Source: Journal of Neurology
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Total 399 results found since Jan 2013.
Carotid endarterectomy in patients with recurrent symptoms associated with an ipsilateral carotid artery near occlusion with full collapse
ConclusionIn patients with RSNOFC, CEA may be considered a potential treatment option. Although procedural risks in this small subgroup may be higher as compared to patients with low-to-moderate risk anatomy, this risk may outbalance the natural course.
Source: Journal of Neurology - June 18, 2018 Category: Neurology Source Type: research
Depressive symptoms in stroke patients treated and non-treated with intravenous thrombolytic therapy: a 1-year follow-up study
Conclusions(1) Thrombolysed and non-thrombolysed stroke survivors had similar frequency of depressive symptoms although the thrombolysed patients had more severe neurological deficits in the acute phase. It can be assumed that if thrombolysis had not been used, depressive symptoms would have been more frequent. (2) Lack of the rt-PA treatment was associated with three-time greater odds of screening for PSD at 3 months post-stroke, after adjustment for other PSD correlates. (3) Therefore, thrombolytic therapy seems to have a positive, but indirect, effect on patients’ mood, especially in the first months after stroke. (...
Source: Journal of Neurology - June 18, 2018 Category: Neurology Source Type: research
Comparison of CT black hole sign and other CT features in predicting hematoma expansion in patients with ICH
ConclusionCT black hole sign presented the best predictive accuracy of predicting HE in patients with ICH compared to other CT features. However, it was not an independent predictor of poor outcome.
Source: Journal of Neurology - June 15, 2018 Category: Neurology Source Type: research
Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
ConclusionsAlthough data is limited, minocycline demonstrated efficacy and seems a promising neuroprotective agent in acute stroke patients, especially in AIS subgroup. Further RCTs are needed to evaluate the efficacy and safety of minocycline among ICH patients.
Source: Journal of Neurology - June 14, 2018 Category: Neurology Source Type: research
Rheumatoid arthritis significantly increased recurrence risk after ischemic stroke/transient ischemic attack
This study provides the first evidence that RA significantly increased recurrence IS/TIA risk. The changes of TG/HDL-C ratio may play some roles in the recurrence IS/TIA risk in RA patients. In addition, our results suggest that smoking increases the risk of recurrent IS/TIA in RA patients and reinforces the need for aggressive smoking cessation efforts in RA patients.
Source: Journal of Neurology - June 2, 2018 Category: Neurology Source Type: research
The occurrence of seizures after ischemic stroke does not influence long-term mortality; a 26-year follow-up study
ConclusionBoth early-onset and late-onset seizures do not influence long-term mortality after ischemic stroke.
Source: Journal of Neurology - May 29, 2018 Category: Neurology Source Type: research
The silver effect of admission glucose level on excellent outcome in thrombolysed stroke patients
AbstractHigher admission glucose levels (AGL) are associated with less favorable outcome in thrombolysis. But, could AGL ’s impact on outcome vary by onset-to-treatment (OTT) time? Is hyperglycemia associated with a shorter therapeutic time window for excellent outcome for thrombolysed stroke patients? We assessed predictive values of AGL, baseline NIHSS, age, and OTT time quartiles on excellent outcome (3-month mod ified Rankin score of 0–1) in 773 patients treated by rt-Pa. We added the AGL × OTT time quartile interaction in the model and separately analyzed the predictive values of AGL, age, and NIHSS for each ...
Source: Journal of Neurology - May 18, 2018 Category: Neurology Source Type: research
Crossed aphasia following cerebral infarction in a right-handed patient with atypical cerebral language dominance
ConclusionThe findings suggest that the patient has right-sided cerebral language dominance, or that both hemispheres have linguistic functions. Not all patients show linguistic capabilities on the side opposite hand preference. The language dominance should be predicted by a combination of clinical manifestations and functional imaging techniques.
Source: Journal of Neurology - May 18, 2018 Category: Neurology Source Type: research
A startling acoustic stimulus facilitates voluntary lower extremity movements and automatic postural responses in people with chronic stroke
AbstractA startling acoustic stimulus (SAS) involuntary releases prepared movements at accelerated latencies, known as the StartReact effect. Previous work has demonstrated intact StartReact in paretic upper extremity movements in people after stroke, suggesting preserved motor preparation. The question remains whether motor preparation of lower extremity movements is also unaffected after stroke. Here, we investigated StartReact effects on ballistic lower extremity movements and on automatic postural responses (APRs) following perturbations to standing balance. These APRs are particularly interesting as they are critical ...
Source: Journal of Neurology - May 14, 2018 Category: Neurology Source Type: research
Haemorrhagic stroke related to the use of 4-fluoroamphetamine
We report on two patients who presented with headache and mild hypertension after 4-FA use. Patient A developed one-sided weakness and decreased consciousness after a few hours. A computed tomography scan showed a left-sided intracerebral haemorrhage. Because of life-threatening cerebral herniation, haematoma evacuation was performed. Postoperatively, she suffered from a right-sided hemiparalysis and severe aphasia, requiring clinical rehabilitation. Patient B had a subarachnoid haemorrhage without neurological deficits. In total, 939 4-FA-intoxicated patients were registered. These patients used 4-FA alone (44%) or in com...
Source: Journal of Neurology - May 8, 2018 Category: Neurology Source Type: research
Body sway during quiet standing post-stroke: effects of individual and interpersonal light touch
Source: Journal of Neurology - April 27, 2018 Category: Neurology Source Type: research
Letter to the editor: insular stroke presenting with acute onset of pain
AbstractPost-stroke pain is a well-known neuropathic pain syndrome but pain at the onset of stroke is a very rare occurrence. We wish to present a case where a stroke in the insular region caused acute-onset lateralized neuropathic pain.
Source: Journal of Neurology - April 23, 2018 Category: Neurology Source Type: research
Patent foramen ovale and stroke
AbstractA patent foramen ovale (PFO) is a highly prevalent finding in cryptogenic ischaemic stroke, particularly in young adults. A common challenge in clinical practice is to distinguish between incidental and pathogenic PFO. Some clinical features and tools such as the Risk of Paradoxical Embolism score may help determining the probability of a stroke-related PFO. Nonetheless, the best therapeutic option to reduce stroke recurrence after a cryptogenic stroke with PFO has been a matter of debate for a long time. We review the mechanisms of stroke-related PFO, together with its clinical features and diagnostic criteria. In...
Source: Journal of Neurology - April 21, 2018 Category: Neurology Source Type: research
Impaired fasting glucose is associated with unfavorable outcome in ischemic stroke patients treated with intravenous alteplase
ConclusionsIFG is associated with unfavorable outcome after treatment with intravenous alteplase for acute ischemic stroke. IFG predicts unfavorable outcome better than hyperglycemia on admission.
Source: Journal of Neurology - April 17, 2018 Category: Neurology Source Type: research
A novel frameshift variant in the CADASIL gene NOTCH3 : pathogenic or not?
AbstractCerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) represents the most common monogenic cause of adult-onset ischemic stroke and vascular dementia. It is caused by heterozygous missense mutations in theNOTCH3 gene, encoding a transmembrane receptor protein on vascular smooth muscle cells. Classical CADASIL mutations affect conserved cysteine residues of the Notch3 protein. By contrast, the role of non-canonical genetic variation inNOTCH3, in particular of variants causing a hypomorphic Notch3 protein, is subject to an ongoing scientific debate. In this context, we h...
Source: Journal of Neurology - March 29, 2018 Category: Neurology Source Type: research
