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Total 17 results found since Jan 2013.
1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University.
Author Contributions
JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research
Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Conclusion
Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin.
Ethics Statement
This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘An...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research
A Serious Diagnosis Lacking Common Symptoms
BY JENNIFER TUONG; IVAN KHARCHENKO; JEAN LUC AGARD; & AHMED RAZIUDDIN, MDA 65-year-old man who had HIV well-controlled with highly active antiretroviral therapy, hypertension, sciatica, and restless leg syndrome presented to the emergency department with left leg pain. He also had had chemotherapy and radiation for anal cancer. The patient said the pain had started 45 minutes earlier when he was sitting on the toilet.He described the pain as sore in quality and 10/10 on the pain scale. He reported that it had started in his lower back and radiated to his left leg. He said he had had no trauma or weakness to the regi...
Source: The Case Files - May 28, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Brain rewires itself after damage or injury, life scientists discover
When the brain's primary "learning center" is damaged, complex new neural circuits arise to compensate for the lost function, say life scientists from UCLA and Australia who have pinpointed the regions of the brain involved in creating those alternate pathways — often far from the damaged site.
The research, conducted by UCLA's Michael Fanselow and Moriel Zelikowsky in collaboration with Bryce Vissel, a group leader of the neuroscience research program at Sydney's Garvan Institute of Medical Research, appears this week in the early online edition of the journal Proceedings of the National Academy of Sciences.
...
Source: UCLA Newsroom: Health Sciences - May 15, 2013 Category: Universities & Medical Training Source Type: news
Meet the Chinese Lumberjack Who Slept With an Alien
"If you can't find me," Meng Zhaoguo said over a cell phone whose signal faded from its isolation, "Just head to the last house on the logging commune lane. Or ask anyone who's around." Everyone knows the first Chinese person to allegedly be abducted by aliens.
With its surging economy, China is summiting once-unseen heights in world rankings: millions of English speakers, almost the most millionaires and actually the least frugal tourists. Yet despite being slightly larger in area than the United States with four times as many people, China trails far behind when it comes to visitors from outer space. To date, only one C...
Source: Science - The Huffington Post - April 7, 2015 Category: Science Source Type: news
Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
Conclusions:
Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521
Received: 22 December 2016
Revised: 17 September 2017
Accepted: 19 September 2017
Published: 19 October 2017
Address correspondence to T. Wu, or A. Pan, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Rd., Wuhan 430030, Hubei, China. Telephone: +86-27-83692347. Email: wut@mails.tjmu.edu.cn or p...
Source: EHP Research - October 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research
Myocardial protection technique structured on cardiac mass.
CONCLUSION: The study group in the aortic valve surgery that administered myocardial protection indexed for the left ventricular mass index and showed a statistically significant lower incidence for post-operative low cardiac output syndrome compared to the control group.
PMID: 31749412 [PubMed - as supplied by publisher]
Source: Perfusion - November 20, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Condello I, Lancellotti P, Speziale G Tags: Perfusion Source Type: research
Boosting 'cellular garbage disposal' can delay the aging process, UCLA biologists report
UCLA life scientists have identified a gene previously implicated in Parkinson's disease that can delay the onset of aging and extend the healthy life span of fruit flies. The research, they say, could have important implications for aging and disease in humans.
The gene, called parkin, serves at least two vital functions: It marks damaged proteins so that cells can discard them before they become toxic, and it is believed to play a key role in the removal of damaged mitochondria from cells.
"Aging is a major risk factor for the development and progression of many neurodegenerative diseases," said David Walke...
Source: UCLA Newsroom: Health Sciences - May 6, 2013 Category: Universities & Medical Training Source Type: news
A Standardized Approach to the Fugl-Meyer Assessment and Its Implications for Clinical Trials
Conclusions. Training with the current method improved accuracy, and reduced variance, of FMA scoring; the 20% FMA variance reduction with training would decrease sample size requirements from 137 to 88 in a theoretical trial aiming to detect a 7-point FMA difference. Minimal detectable change was much smaller than FMA minimal clinically important difference. The variation in FMA gains in relation to baseline FMA suggests that future trials consider a sliding outcome approach when FMA is an outcome measure. The current training approach may be useful for assessing motor outcomes in restorative stroke trials.
Source: Neurorehabilitation and Neural Repair - September 18, 2013 Category: Neurology Authors: See, J., Dodakian, L., Chou, C., Chan, V., McKenzie, A., Reinkensmeyer, D. J., Cramer, S. C. Tags: Clinical Research Articles Source Type: research
Report on the 5‘th scientific meeting of the “Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie” (NEUROWIND e.V.) held in Motzen, Germany, Oct. 25th – Oct. 27th, 2013
Abstract
From october 25th - 27th 2013, the 5th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. This year more than 60 doctoral students and postdocs from over 25 different groups working in German university hospitals or research institutes attended the meeting to discuss their latest findings in the fields of neuroimmunology, neurodegeneration and neurovascular research. All participants appreciated the stimulating environment in Motzen, Brandenburg, and people took the opportunity for scientific exchange, discussion about ongoing projects and already started further collaborations. Like in the...
Source: Experimental and Translational Stroke Medicine - December 11, 2013 Category: Neurology Source Type: research
Brain’s reaction to virtual reality should prompt further study, suggests new research by UCLA neuroscientists
UCLA neurophysicists have found that space-mapping neurons in the brain react differently to virtual reality than they do to real-world environments. Their findings could be significant for people who use virtual reality for gaming, military, commercial, scientific or other purposes.
“The pattern of activity in a brain region involved in spatial learning in the virtual world is completely different than when it processes activity in the real world,” said Mayank Mehta, a UCLA professor of physics, neurology and neurobiology in the UCLA College and the study’s senior author. “Since so many people are using virtual r...
Source: UCLA Newsroom: Health Sciences - November 25, 2014 Category: Universities & Medical Training Source Type: news
Reply Primum Non Nocere: First Do No Harm
Discussion section, the strong correlation shown in Figure 4A would not be possible if variability of afterload was an important consideration.3.If aortic regurgitation were underestimated by MRI, it would lead to an overestimation of mitral regurgitant volume, not an underestimation.4.We do not believe our study shows that pre-surgical left ventricular (LV) volumes predict recovery of LV end-diastolic volume (EDV) post-surgery. For example, in Table 4, patient 29 had mild mitral regurgitation (MR) and an end-diastolic diameter (EDD) of 6.2 cm, whereas patient 38 had severe MR and an EDD of 5.3 cm. Our study shows that ...
Source: Journal of the American College of Cardiology - July 20, 2015 Category: Cardiology Source Type: research
Does communication partner training improve the conversation skills of speech-language pathology students when interacting with people with aphasia?
CONCLUSION: Speech-language pathology students may benefit from participation in communication partner training programs.
PMID: 28618297 [PubMed - as supplied by publisher]
Source: Journal of Communication Disorders - May 26, 2017 Category: Speech-Language Pathology Authors: Finch E, Cameron A, Fleming J, Lethlean J, Hudson K, McPhail S Tags: J Commun Disord Source Type: research
Reena ’s story: A bright future with short bowel syndrome
She’s just 16, but Reena Zuckerman knows exactly what she wants to be doing in another 10 years. “My dream is to play on the press team in the annual Women’s Congressional Softball Game,” says the aspiring political journalist. Since 2009, the event has pitted members of Congress against the press corps, raising nearly a million dollars for charity. “When I’m not doing schoolwork or watching TV, I’m listening to political podcasts and NPR,” Reena confesses.
It’s an impressive goal, but one that’s no doubt attainable for this driven teen, who’s been pushing herself to defy expectations since she was a ...
Source: Thrive, Children's Hospital Boston - November 10, 2017 Category: Pediatrics Authors: Jessica Cerretani Tags: Diseases & Conditions Our Patients’ Stories Center for Advanced Intestinal Rehabilitation Dr. Tom Jaksic G-tube short bowel syndrome (SBS). volvulus Source Type: news
