A Standardized Approach to the Fugl-Meyer Assessment and Its Implications for Clinical Trials

Conclusions. Training with the current method improved accuracy, and reduced variance, of FMA scoring; the 20% FMA variance reduction with training would decrease sample size requirements from 137 to 88 in a theoretical trial aiming to detect a 7-point FMA difference. Minimal detectable change was much smaller than FMA minimal clinically important difference. The variation in FMA gains in relation to baseline FMA suggests that future trials consider a sliding outcome approach when FMA is an outcome measure. The current training approach may be useful for assessing motor outcomes in restorative stroke trials.

Source: Neurorehabilitation and Neural Repair - September 18, 2013 Category: Neurology Authors: See, J., Dodakian, L., Chou, C., Chan, V., McKenzie, A., Reinkensmeyer, D. J., Cramer, S. C. Tags: Clinical Research Articles Source Type: research