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Strokes after TIAs have declined over time, study shows
(University of Texas Health Science Center at San Antonio) Patients who have transient ischemic attacks (TIAs) are at risk of subsequent stroke and require longer follow-up that previously thought, according to researchers from The University of Texas Health Science Center at San Antonio and Harvard Medical School.
Source: EurekAlert! - Medicine and Health - January 26, 2021 Category: International Medicine & Public Health Source Type: news

Prevalence of and Risk Factors for Cerebral Microbleeds in Moyamoya Disease and Syndrome in the American Population
Conclusions: CMB are less prevalent in MMD/MMS in the USA than in Asia. An older age at diagnosis and male gender were associated with CMB. The presence of CMB was not associated with an increased risk of a subsequent ischemic or hemorrhagic stroke.Cerebrovasc Dis Extra 2019;9:139 –147
Source: Cerebrovascular Diseases Extra - December 12, 2019 Category: Neurology Source Type: research

World-Wide Efficacy of Bone Marrow Derived Mesenchymal Stromal Cells in Preclinical Ischemic Stroke Models: Systematic Review and Meta-Analysis
Conclusions: Our results show worldwide efficacy of BM-MSCs in improving functional outcomes in pre-clinical animal models of stroke and support testing these cells in clinical trials in various ranges of time windows using different delivery routes. The continued growing number of publications showing functional benefit of BM-MSCs are now adding limited value to an oversaturated literature spanning 18 years. Researchers should focus on identifying definitive mechanisms on how BM-MSCs lead to benefit in stroke models. Introduction Ischemic stroke is the 5th leading cause of death and the leading cause of long term di...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Pre-injury Comorbidities Are Associated With Functional Impairment and Post-concussive Symptoms at 3- and 6-Months After Mild Traumatic Brain Injury: A TRACK-TBI Study
Conclusions: Pre-injury psychiatric and pre-injury headache/migraine symptoms are risk factors for worse functional and post-concussive outcomes at 3- and 6-months post-mTBI. mTBI patients presenting to acute care should be evaluated for psychiatric and headache/migraine history, with lower thresholds for providing TBI education/resources, surveillance, and follow-up/referrals. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT01565551. Introduction Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality worldwide. In 2013 ~2.8 million TBI cases were recorded an...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Stroke prevention drug combo shows promise, study says
(University of Texas at Austin) If you've had a minor stroke or a transient ischemic stroke (TIA), taking the clot-preventing drug clopidogrel along with aspirin may lower your risk of having a major stroke within the next 90 days, according to new research published in The New England Journal of Medicine.
Source: EurekAlert! - Medicine and Health - May 16, 2018 Category: International Medicine & Public Health Source Type: news

Stem cell trial for stroke patients suffering chronic motor deficits begins at UTHealth
(University of Texas Health Science Center at Houston) A clinical trial to evaluate the safety and efficacy of a stem cell product injected directly into the brain to treat chronic motor deficits from ischemic stroke has begun at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).
Source: EurekAlert! - Medicine and Health - May 15, 2017 Category: International Medicine & Public Health Source Type: news

Radiation Monitoring Results from the First Year of Operation of a Unique Ambulance-based Computed Tomography Unit for the Improved Diagnosis and Treatment of Stroke Patients.
Abstract When a blood clot blocks the blood supply to the brain or when a blood vessel bursts, resulting in brain cell death, the medical condition is referred to as a "stroke." Stroke is a main cause of death worldwide and is a common cause of disability. A common form of stroke, called ischemic stroke, is when blood flow to the brain is decreased. Clinical research has revealed that treatment within the very first hours of symptom onset is key for ischemic stroke with recanalization of occluded arteries by thrombolysis with alteplase. Computed tomography (CT) is one of the diagnostic tools used to determine if t...
Source: Health Physics - March 31, 2016 Category: Physics Authors: Gutiérrez JM, Emery RJ, Parker SA, Jackson K, Grotta JC Tags: Health Phys Source Type: research

Ischemic stroke in patients with gliomas at The University of Texas-M.D. Anderson Cancer Center
Abstract Patients with gliomas are at risk of cerebrovascular accidents (CVA) with potential consequences on survival, function, and local tumor control. Our objective was to provide information about CVA in patients with gliomas and to estimate survival in this group. We reviewed all adult glioma patients with ischemic CVA at the University of Texas-M.D. Anderson Cancer Center from 2003 through 2014. We extracted demographic, clinical, imaging, treatment and outcome data. We used descriptive summary data and estimated or compared survival rates where appropriate. 60 of 6500 patients (0.1 %) with high-grade (HGG,...
Source: Journal of Neuro-Oncology - August 14, 2015 Category: Cancer & Oncology Source Type: research

Atypical isolated nuclear oculomotor nerve syndrome: A diagnostic challenge (P1.031)
CONCLUSION: This report will raise the awareness about nuclear oculomotor nerve syndrome and lead to a potentially successful therapeutic approach.Disclosure: Dr. Liao has nothing to disclose. Dr. Kamiya Matsuoka has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kamiya Matsuoka, C., Liao, B. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Clotting Factors to Treat Thrombolysis-related Symptomatic Intracranial Hemorrhage in Acute Ischemic Stroke
Conclusions: We found no evidence that treatment for sICH with clotting factors has a favorable effect on clinical or radiological outcomes. However, the sample was small because of the low frequency of sICH. New treatments are urgently needed for this uncommon yet serious condition.
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2013 Category: Neurology Authors: Yazan J. Alderazi, Niravkumar V. Barot, Hui Peng, Farhaan S. Vahidy, Digvijaya D. Navalkele, Navdeep Sangha, Vivek Misra, Sean I. Savitz Tags: Original Articles Source Type: research

Optimizing Prediction Scores for Poor Outcome After Intra-Arterial Therapy in Anterior Circulation Acute Ischemic Stroke Clinical Sciences
Conclusions— The HIAT2 score, which combines clinical and imaging variables, performed better than all previous scores in predicting poor outcome after IAT for anterior circulation large artery occlusions.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Sarraj, A., Albright, K., Barreto, A. D., Boehme, A. K., Sitton, C. W., Choi, J., Lutzker, S. L., Sun, C.-H. J., Bibars, W., Nguyen, C. B., Mir, O., Vahidy, F., Wu, T.-C., Lopez, G. A., Gonzales, N. R., Edgell, R., Martin-Schild, S., Hallevi, H., Chen, P. Tags: Acute Cerebral Infarction, Angioplasty and Stenting Clinical Sciences Source Type: research

Predicting the need for hospital admission of TIA patients
Abstract: Background: It is unknown which patient will benefit most from hospital admission after transient ischemic attack (TIA). Our aim was to define predictors of a positive hospital outcome.Methods: We used two cohorts of TIA patients: the University of Texas at Houston Stroke Center (UTH); and Tel-Aviv Sourasky Medical Center in Israel (TASMC) for external validation. We retrospectively reviewed medical records and imaging data.We defined positive yield (PY) of the hospital admission as identification of stroke etiologies that profoundly changes clinical management.Results: The UTH cohort included 178 patients. 24.7%...
Source: Journal of the Neurological Sciences - October 28, 2013 Category: Neurology Authors: Indrani Acosta, Sivan Bloch, Miriam Morales, Natan M. Bornstein, Sean I. Savitz, Hen Hallevi Tags: Original Articles Source Type: research

Effectiveness of clot-buster enhanced by ultrasound device in stroke patients
A study led by researchers at The University of Texas Health Science Center at Houston (UTHealth) showed that a hands-free ultrasound device combined with a clot-busting drug was safe for ischemic stroke patients. The results of the phase II pilot study were reported in the American Heart Association journal Stroke. Lead author is Andrew D. Barreto, M.D., assistant professor of neurology in the Stroke Program at the UTHealth Medical School. Principal investigator is James C. Grotta, M.D., professor and chair of the Department of Neurology at the UTHealth Medical School, the Roy M...
Source: Health News from Medical News Today - October 27, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Ultrasound device combined with clot-buster safe for stroke, say UTHealth researchers
(University of Texas Health Science Center at Houston) A study led by researchers at the University of Texas Health Science Center at Houston showed that a hands-free ultrasound device combined with a clot-busting drug was safe for ischemic stroke patients.
Source: EurekAlert! - Medicine and Health - October 24, 2013 Category: Global & Universal Source Type: news