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Total 60 results found since Jan 2013.

Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies Clinical Sciences
Conclusions— Overall, the use of NSAIDs is not associated with an increased risk of hemorrhagic stroke, although this risk was modestly significantly elevated in diclofenac and meloxicam users.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Ungprasert, P., Matteson, E. L., Thongprayoon, C. Tags: Risk Factors, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Clinical Sciences Source Type: research

FDA strengthens warning that NSAIDs increase heart attack and stroke risk
Back in 2005, the FDA warned that taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen increased the risk of having a heart attack or stroke. Last week it took the unusual step of further strengthening this warning. This was done on the advice of an expert panel that reviewed new information about NSAIDs and their risks. Because NSAIDs are widely used, it’s important to be aware of downsides of taking an NSAID and to take steps to limit the risk. Many people take NSAIDs to relieve mild to moderate pain. These medications may be particularly effective in conditions in which pain results pri...
Source: New Harvard Health Information - July 13, 2015 Category: Consumer Health News Authors: Gregory Curfman, MD Tags: Heart Health heart attack heart disease NSAIDS Stroke Source Type: news

Preadmission use of nonaspirin nonsteroidal anti-inflammatory drugs and 30-day stroke mortality
Conclusions: Preadmission use of COX-2 inhibitors was associated with increased 30-day mortality after ischemic stroke, but not hemorrhagic stroke. Use of nonselective NSAIDs at time of admission was not associated with mortality from ischemic stroke or intracerebral hemorrhage.
Source: Neurology - November 24, 2014 Category: Neurology Authors: Schmidt, M., Hovath-Puho, E., Christiansen, C. F., Petersen, K. L., Botker, H. E., Sorensen, H. T. Tags: Outcome research, All Cerebrovascular disease/Stroke, All epidemiology, Cohort studies ARTICLE Source Type: research

Risk of Hemorrhagic Stroke in Patients Exposed to Nonsteroidal Anti-Inflammatory Drugs: A Meta-Analysis of Observational Studies
Conclusion: Our results indicated that the use of NSAIDs is significantly associated with a higher risk of developing hemorrhagic stroke. These results should be interpreted with caution because they may be confounded owing to the observational design of the individual studies. Nevertheless, we recommend that NSAIDs should be used judiciously, and their efficacy and safety should be monitored proactively.Neuroepidemiology 2018;51:166 –176
Source: Neuroepidemiology - September 2, 2018 Category: Epidemiology Source Type: research

Risk of ischaemic stroke associated with non-steroidal antiinflammatory drugs and paracetamol: a population-based case-control study.
CONCLUSIONS: Diclofenac and aceclofenac increase the risk of ischaemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients at high background CV risk. This article is protected by copyright. All rights reserved. PMID: 25611553 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 22, 2015 Category: Hematology Authors: García-Poza P, de Abajo FJ, Gil MJ, Chacón A, Bryant V, García-Rodríguez LA Tags: J Thromb Haemost Source Type: research

Common Painkiller Linked To Heart Attack And Stroke, UK Warning
Common painkiller, diclofenac, raises the risk of heart attack and stroke among patients with serious underlying heart conditions, the UK's Medicines and Healthcare Products Regulatory Agency (MHRA) has warned. MHRA specifies that patients with circulatory problems, heart disease, heart failure, or a previous stroke or heart attack should stop using diclofenac. Diclofenac is known under several trade names, including Diclomax, Defenac, Diclofex, Dyloject, Econac, Enstar, Flamrase, Flamatak, Motifene, Rheumatac, Rhumalgan, Volsaid, and Voltarol...
Source: Health News from Medical News Today - July 1, 2013 Category: Consumer Health News Tags: Pain / Anesthetics Source Type: news

COX-2 Inhibitors Linked to Stroke Mortality COX-2 Inhibitors Linked to Stroke Mortality
New data show the previously reported increased risk for cardiovascular events with these pain meds includes increased stroke death; risk was driven by older drugs, such as etodolac and diclofenac. Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - November 6, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Risk of ischaemic stroke associated with non‐steroidal antiinflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischaemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients at high background CV risk.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 22, 2015 Category: Hematology Authors: Patricia García‐Poza, Francisco J. Abajo, Miguel J. Gil, Ana Chacón, Verónica Bryant, Luis A. García‐Rodríguez Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Risk of ischemic stroke associated with non‐steroidal anti‐inflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients with a high background CV risk.
Source: Journal of Thrombosis and Haemostasis - February 24, 2015 Category: Hematology Authors: P. García‐Poza, F. J. Abajo, M. J. Gil, A. Chacón, V. Bryant, L. A. García‐Rodríguez Tags: Original Article Source Type: research

Continuous intravenous low-dose diclofenac sodium to control a central fever after ischemic stroke in the intensive care unit: a case report and review of the literature
ConclusionsWe observed that a low-dose diclofenac sodium infusion was effective in treating fever without systemic side effects. This treatment may be suggested as an alternative to conventional antipyretic drugs, but additional clinical trials are required.
Source: Journal of Medical Case Reports - December 17, 2019 Category: General Medicine Source Type: research

Low-dose Diclofenac to Control Fever After Ischemic Stroke Low-dose Diclofenac to Control Fever After Ischemic Stroke
Central fever following ischemic stroke is fairly common and associated with worse outcomes. Might the NSAID diclofenac sodium be an effective antipyretic in this situation?Journal of Medical Case Reports
Source: Medscape Today Headlines - February 25, 2020 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Commonly used painkiller 'should be banned over heart risk'
A painkiller used by at least a million people in Britain a year should be banned because it raises the risk of heart attack and stroke by almost half, say British academics.
Source: Telegraph Health - February 12, 2013 Category: Consumer Health News Tags: heart attack ibuprofen diclofenac nsaid stroke Source Type: news

Use of Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Relation to Cardiovascular Events: A Systematic Pharmacoepidemiological Review.
CONCLUSION: Further research is needed in order to devise new guidelines for safer use of NSAIDs. PMID: 27468710 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - July 26, 2016 Category: Drugs & Pharmacology Authors: Kontogiorgis C, Valikeserlis I, Hadjipavlou-Litina D, Nena E, Constantinidis TC Tags: Curr Vasc Pharmacol Source Type: research

High-dose painkiller heart risk: small but significant
Conclusion This large review adds to, and expands on, the current evidence on the risks of vascular disease and gastrointestinal complications for different NSAIDs. It largely concentrates on trials of high doses of NSAIDs that can only be prescribed by a doctor. It is unclear from this study whether there is any risk from taking lower doses available over the counter. While most experts advise that low-dose NSAIDs, taken occasionally, are safe for most people, an accompanying editorial points out that there are still “large gaps” in evidence on the risks with lower doses of NSAIDs. While the risk to individuals is sma...
Source: NHS News Feed - May 30, 2013 Category: Consumer Health News Tags: Medication Heart/lungs Source Type: news

Painkiller increases chance of heart attack, health officials advise
Experts says patients with heart conditions should stop using diclofenac after study finds stroke and heart attack linkHealth officials have advised patients with heart problems to avoid an over-the-counter painkiller used by millions after research found that it can significantly increase the risk of heart attack or stroke.The Medicines and Healthcare products Regulatory Agency (MHRA) said that patients with an underlying heart condition, such as heart failure, heart disease or circulatory problems, or patients who have previously suffered heart attacks or strokes, should no longer use diclofenac.An MHRA spokesman said th...
Source: Guardian Unlimited Science - June 29, 2013 Category: Science Tags: Heart attack The Guardian News Health Society Drugs UK news Science Source Type: news