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Condition: Peripheral Vascular Disease (PVD)
Drug: Insulin
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Total 120 results found since Jan 2013.
Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study
Int J Mol Sci. 2023 Apr 27;24(9):7934. doi: 10.3390/ijms24097934.ABSTRACTIschemic cardiovascular diseases (CVD) originate from an imbalance between atherosclerotic plaque formation, instability, and endothelial healing dynamics. Our aim was to examine the relationship between 5-year changes in inflammatory, metabolic, and oxidative biomarkers and 10-year CVD incidence in a population without previous CVD. This was a prospective cohort study of individuals aged 35-74 years (n = 419) randomly selected from 5263 REGICOR participants without CVD recruited in 2005. Biomarkers were measured at baseline and in 2010. Participants ...
Source: Atherosclerosis - May 13, 2023 Category: Cardiology Authors: Anna Camps-Vilaro Isaac Subirana Rafel Ramos Miguel Cainzos-Achirica Helena Tizon-Marcos Montse Fito Irene R Degano Jaume Marrugat Source Type: research
Clinical Characteristics of Inpatients With New-Onset Diabetes Mellitus in Eastern China: Based on Novel Clustering Analysis
ConclusionsThe inpatients with new-onset diabetes in Eastern China had the unique clustering distribution. The clinical characteristics, treatments, and diabetes-related complications and comorbidities of the five subgroups were different, which may provide the basis for precise treatments of diabetes.
Source: Frontiers in Endocrinology - July 27, 2022 Category: Endocrinology Source Type: research
The effects of omega-3 fatty acids in type 2 diabetes: A systematic review and meta-analysis
The number of patients with type 2 diabetes continues to increase worldwide, the disease currently affects more than 463 million people worldwide and accounts for 10% of health care spending according to data by the World Health Organization[1]. Type 2 diabetes is a multifactorial disease that is caused by pancreatic beta-cell dysfunction and insulin resistance in peripheral tissues[2], and both morbidity and mortality are high particularly due to its associated macrovascular diseases complications (Coronary artery disease (CAD), peripheral artery disease (PAD) and stroke), as well as microvascular disease complications (d...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 3, 2022 Category: Biomedical Science Authors: Yanan Xiao, Qifang Zhang, Xueling Liao, Ulf Elbelt, Karsten H. Weylandt Tags: Original research article Source Type: research
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study
CONCLUSION: We provided evidence for the causal effects of T2DM and glycemic traits on the risk of CVDs and dyslipidemia. Further investigations to elucidate the underlying mechanisms are warranted.PMID:35528012 | PMC:PMC9072667 | DOI:10.3389/fendo.2022.840579
Source: Atherosclerosis - May 9, 2022 Category: Cardiology Authors: Mingkai Huang Loum-Davadi Laina-Nicaise Lingfeng Zha Tingting Tang Xiang Cheng Source Type: research
Differentiating Associations of Glycemic Traits with Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation
Diabetes. 2022 May 2:db210905. doi: 10.2337/db21-0905. Online ahead of print.ABSTRACTWe conducted a Mendelian randomization analysis to differentiate associations of four glycemic indicators with a broad range of atherosclerotic and thrombotic diseases. Independent genetic variants associated with fasting glucose (FG), 2-h glucose after an oral glucose challenge (2hGlu), fasting insulin (FI), and glycated hemoglobin (HbA1c) at the genome-wide significance threshold were used as instrumental variables. Summary-level data for 12 atherosclerotic and 4 thrombotic outcomes were obtained from large genetic consortia and the Finn...
Source: Atherosclerosis - May 2, 2022 Category: Cardiology Authors: Shuai Yuan Amy M Mason Stephen Burgess Susanna C Larsson Source Type: research
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study
ConclusionWe provided evidence for the causal effects of T2DM and glycemic traits on the risk of CVDs and dyslipidemia. Further investigations to elucidate the underlying mechanisms are warranted.
Source: Frontiers in Endocrinology - April 22, 2022 Category: Endocrinology Source Type: research
Ischemic risk in patients with heart failure with preserved ejection fraction: A post hoc analysis of the TOPCAT data
CONCLUSIONS: HFpEF patients from Americas were at a high risk of ischemic events, which was associated with mortality risk. A subset of baseline characteristics and HF hospitalization during follow-up could predict ischemic event.PMID:35101783 | DOI:10.1016/j.atherosclerosis.2022.01.013
Source: Atherosclerosis - February 1, 2022 Category: Cardiology Authors: Xin He Bin Dong Weihao Liang Yuzhong Wu Yili Chen Yugang Dong Jiangui He Chen Liu Source Type: research
Ten-year all-cause death following percutaneous or surgical revascularization in patients with prior cerebrovascular disease: insights from the SYNTAX Extended Survival study
ConclusionPrior CEVD was associated with a significantly increased risk of 10 year all-cause death which was similar in patients treated with PCI or CABG. These results do not support preferential referral for PCI rather than CABG in patients with prior CEVD.Trial registration: SYNTAX: ClinicalTrials.gov reference: NCT00114972. SYNTAX Extended Survival: ClinicalTrials.gov reference: NCT03417050.Graphic abstract
Source: Clinical Research in Cardiology - October 1, 2021 Category: Cardiology Source Type: research
Midkine: a multifaceted driver of atherosclerosis
Clin Chim Acta. 2021 Jul 28:S0009-8981(21)00264-3. doi: 10.1016/j.cca.2021.07.024. Online ahead of print.ABSTRACTAtherosclerosis constitutes the pathological basis of life-threatening events, including heart attack and stroke. Midkine is a heparin-binding growth factor and forms a small protein family with pleiotrophin. Under inflammatory or hypoxic conditions, midkine expression is up-regulated. Upon binding to its receptors, midkine can activate multiple signal pathways to regulate cell survival and migration, epithelial-to-mesenchymal transition, and oncogenesis. Circulating midkine levels are significantly increased in...
Source: International Journal of Clinical Chemistry - July 31, 2021 Category: Chemistry Authors: Zi-Zhen Zhang Gang Wang Shan-Hui Yin Xiao-Hua Yu Source Type: research
Research Progress on Catalpol as Treatment for Atherosclerosis
Coronary atherosclerotic heart disease, cerebrovascular disease, and peripheral artery disease are common diseases with high morbidity and mortality rates and must be addressed. Their most frequent complications, including myocardial infarction and stroke, are caused by spontaneous thrombotic occlusion and are the most frequent cause of death worldwide. Atherosclerosis (AS) is the most widespread underlying pathological change for the above diseases. Therefore, drugs that interfere with this pathophysiological process must be incorporated in the treatment. Chinese traditional and herbal drugs can effectively treat AS. With...
Source: Frontiers in Pharmacology - July 13, 2021 Category: Drugs & Pharmacology Source Type: research
A prospective observational study of preoperative natriuretic peptide testing in adult non-cardiac surgical patients in hospitals in Western Cape Province, South Africa
CONCLUSIONS: We strongly recommend that non-cardiac surgical patients aged ≥45 years undergoing intermediate- or high-risk non-cardiac surgery with a history of coronary artery disease/peripheral vascular disease, congestive cardiac failure, diabetes mellitus or elevated creatinine have preoperative NP testing as part of risk stratification.PMID:33944767 | DOI:10.7196/SAMJ.2021.v111i4.15226
Source: Molecular Medicine - May 4, 2021 Category: Molecular Biology Authors: C S Alphonsus M Jagga M Crowther E Coetzee G Davies Z Fullerton H A Van Zyl A Reed E Cloete J Roos F Roodt R N Rodseth B M Biccard Collaborators for EPIC2: BNP study Source Type: research
