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Total 84 results found since Jan 2013.

Clinical effectiveness of ultrasound guided subacromial-subdeltoid bursa injection of botulinum toxin type A in hemiplegic shoulder pain: A retrospective cohort study
Hemiplegic shoulder pain (HSP), which occurs in most patients with hemiplegia, causes considerable distress and worsens outcomes in rehabilitation. Although they have received the treatments such as anti-inflammatory drugs or physical therapy, many of the individuals remain suffering from shoulder pain 6 months after acute stroke event. In this retrospective study, we evaluated the effectiveness of ultrasound guided subacromial-subdeltoid (SASD) bursa injections with botulinum toxin type A (BoNT/A) compared to steroids for refractory HSP. The data were collected retrospectively by reviewing the patient's medical records a...
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Botuloscope: 1-year follow-up of upper limb post-stroke spasticity treated with botulinum toxin
ConclusionThis is the first long-term follow-up of BoNT-A treatment for upper limb spasticity involving a large cohort independent of industry. Quality of life was improved by treating upper limb spasticity with BoNT-A, even at 5 years post-stroke. Personalizing objectives of the treatment amplified its efficacy. BoNT-A was a powerful analgesic when pain was spasticity-related. Treating the spastic upper limb also improved balance and gait abilities.
Source: Annals of Physical and Rehabilitation Medicine - June 25, 2019 Category: Rehabilitation Source Type: research

Botuloscope: 1-year follow-up of upper-limb post-stroke spasticity treated with botulinum toxin
Conclusion. This is the first long-term follow-up of BoNT-A treatment for upper-limb spasticity involving a large cohort independent of industry. Quality of life was improved by treating upper-limb spasticity with BoNT-A, even at 5 years post-stroke. Personalizing objectives of the treatment amplified its efficacy. BoNT-A was a powerful analgesic when pain was spasticity-related. Treating the spastic upper limb also improved balance and gait abilities.
Source: Annals of Physical and Rehabilitation Medicine - June 22, 2019 Category: Rehabilitation Source Type: research

Electrical stimulation of antagonist muscles after botulinum toxin type A for post-stroke spastic equinus foot. A randomized single-blind pilot study
Conclusions. ES of antagonist muscles does not improve clinical outcomes in the post-stroke spastic equinus foot after BoNT-A injection.
Source: Annals of Physical and Rehabilitation Medicine - June 20, 2019 Category: Rehabilitation Source Type: research

Botulinum Toxin Modulates Posterior Parietal Cortex Activation in Post-stroke Spasticity of the Upper Limb
Post-stroke spasticity (PSS) is effectively treated with intramuscular botulinum toxin type A (BoNT-A), although the clinical improvement is likely mediated by changes at the central nervous system level. Using functional magnetic resonance imaging (fMRI) of the brain, this study aims to confirm and locate BoNT-A-related changes during motor imagery with the impaired hand in severe PSS. Temporary alterations in primary and secondary sensorimotor representation of the impaired upper limb were expected. Thirty chronic stroke patients with upper limb PSS undergoing comprehensive treatment including physiotherapy and indicat...
Source: Frontiers in Neurology - May 8, 2019 Category: Neurology Source Type: research

Pain and muscles properties modifications after botulinum toxin type A (BTX-A) and radial Extracorporeal Shock Wave (rESWT) combined treatment.
CONCLUSIONS: Radial Extracorporeal Shock Wave Therapy could be an effective physical treatment aimed at the reduction of upper and lower limbs spasticity and could lead to the improvement of trophic conditions of the spastic muscles in post-stroke. PMID: 30843498 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 8, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Botulinum Toxin Type A for the Treatment of Lower Limb Spasticity after Stroke
AbstractPost-stroke lower limb spasticity impairs balance and gait leading to reduced walking speed, often increasing wheelchair use and caregiver burden. Several studies have shown that appropriate treatments for lower limb spasticity after stroke include injections of botulinum toxin type A (BoNT-A), phenol or alcohol, surgical correction and a rehabilitation program. In the present article, we review the safety and effectiveness of BoNT-A for the treatment of lower limb spasticity after stroke, with a focus on higher doses of BoNT-A. The cumulative body of evidence coming from the randomized clinical trials and open-lab...
Source: Drugs - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

A case study investigating the efficacy of two treatments, botox and SaeboFlex in reduced hand function due to flexor spasticity
Purpose: Dynamic hand splints such as Saeboflex are a promising intervention for aiding functional use of a person's hand following a stroke. If spasticity is present it can be a major limiting factor in using a Saeboflex. The purpose of this case study is to report the use of a combination of Botulinum Toxin Type A (BtxA) to reduce spasticity, prior to initiating a repetitive training rehabilitation programme with a Saeboflex.
Source: Physiotherapy - January 1, 2019 Category: Physiotherapy Authors: J.A. Benson Tags: P087 Source Type: research

Safety Profile of High-Dose Botulinum Toxin Type A in Post-Stroke Spasticity Treatment
AbstractBotulinum toxin type A (BoNT-A) is considered the gold standard for the treatment of focal post-stroke spasticity (PSS). However, a recently published study estimated that a significant percentage of patients affected by PSS could benefit from higher doses of BoNT-A than those permitted by current directives in the countries studied. Several studies have reported the use of high doses of BoNT-A in the management of patients affected by severe PSS; however, the most important adverse effect of this drug might be systemic diffusion of the toxin, which could potentially be related to its dose. Even if systemic toxicit...
Source: Clinical Drug Investigation - September 12, 2018 Category: Drugs & Pharmacology Source Type: research

The Effects of Botulinum Toxin Injections on Plantar Flexor Spasticity in Different Phases After Stroke: A Secondary Analysis From a Double-Blind, Randomized Trial
ConclusionsOur serial measurements of the outcome parameters indicated that BT-A could be expected to lead to consistent improvement in both the muscle tone and gait quality in those with plantar flexor spasticity regardless of stroke chronicity, including those injected as early as within the first 6 months.Level of EvidenceI
Source: PMandR - August 21, 2018 Category: Rehabilitation Source Type: research

Botulinum Toxin Type A Treatment Combined with Intensive Rehabilitation for Gait Poststroke: A Preliminary Study
To examine the effects of botulinum toxin type A (BoNT-A) treatment combined with intensive rehabilitation for gait compared with intensive rehabilitation alone in patients with chronic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2018 Category: Neurology Authors: Yuki Uchiyama, Tetsuo Koyama, Yosuke Wada, Masashi Katsutani, Norihiko Kodama, Kazuhisa Domen Source Type: research

Functional outcomes following ultrasound-guided botulinum toxin type A injections to reduce spastic equinovarus in adult post-stroke patients.
CONCLUSION: Spastic equinovarus deformity observed in patients after stroke creates significant limitations in the patient's functional walking speed and distance. As a result, when BoNT-A injections accompanied by ultrasound to improve equinovarus deformity considering the innervation zones of the muscles with a specific approach are administered directly into the muscle at the correct point, we can say it provides hopeful results from a functional point of view. PMID: 29530514 [PubMed - as supplied by publisher]
Source: Toxicon - March 9, 2018 Category: Toxicology Authors: Aktürk S, Büyükavcı R, Ersoy Y Tags: Toxicon Source Type: research

Evaluating the functional outcomes of ultrasound-guided botulinum toxin type A injections using the Euro-musculus approach for upper limb spasticity treatment in post-stroke patients; an observational study.
CONCLUSIONS: Ultrasound-guided botulinum toxin type A injection via the Euro- musculus spasticity approach is a practical and effective method for administering injections to the correct point of the correct muscle. Ultrasound-guided botulinum toxin type A injections combined with rehabilitation programmes decrease spasticity and improve the upper extremity motor functions in stroke patients. CLINICAL REHABILITATION IMPACT: This new approach for ultrasound- guided botulinum toxin type A injection is very practical and effective method for upper extremity spasticity. PMID: 29422486 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - February 7, 2018 Category: Rehabilitation Authors: Buyukavci R, Akturk S, Ersoy Y Tags: Eur J Phys Rehabil Med Source Type: research

Analysis of a 15-years' experience in including shoulder muscles, when treating upper-limb spasticity post-stroke with botulinum toxin type A.
Conclusion When treating ULS, including shoulder muscles, the most frequent goals were IM, PD e MOB. The most injected muscles were SC and PM. The treatment was successful in a large percentage of cases. Achieving the PD goal was associated with greater success at other goals of treatment. BoNTA demonstrated a positive effect in controlling symptoms and improving function. PMID: 29322885 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - January 11, 2018 Category: Neurology Authors: Carvalho MP, Pinto D, Gorayeb M, Jacinto J Tags: Top Stroke Rehabil Source Type: research