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Focal Anticoagulation by Somatic Gene Transfer: Towards Preventing Cardioembolic Stroke
Cardioembolic stroke (CS) has emerged as a leading cause of ischaemic stroke (IS); distinguished by thrombi embolising to the brain from cardiac origins; most often from the left atrial appendage (LAA). Contemporary therapeutic options are largely dependent on systemic anticoagulation as a blanket preventative strategy, yet this does not represent a nuanced or personalised solution. Contraindications to systemic anticoagulation create significant unmedicated and high-risk cohorts, leaving these patients at risk of significant morbidity and mortality.
Source: Heart, Lung and Circulation - June 12, 2023 Category: Cardiology Authors: Megha Kadian, Cindy Y. Kok, Dhanya Ravindran, Freda Passam, Leonardo Pasalic, Eddy Kizana Tags: Original Article Source Type: research

Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: expression changes of NMDA receptor subunits and NT-3
This study was designed to discover the effect of MSCs injection in the nucleus accumbens (NAc) on the reinstatement of behavior in morphine-induced conditioned place preference (CPP) in male rats. The CPP was induced via intra-peritoneal (i.p.) morphine injection (5mg/kg) for three consecutive days. After being tested for CPP induction, animals received MSCs or culture medium (DMEM F-12) in their NAc using stereotaxic surgery. Following extinction, a priming dose of morphine (2mg/kg) was administered to induce reinstatement. Expression of GluN1, GluN2A, and GluN2B subunits of the NMDA receptor and the NT-3 gene in the NAc...
Source: Cell Research - February 28, 2023 Category: Cytology Authors: Parviz Dousti Kataj Nasim Vousooghi Mahmoud Reza Hadjighassem Maryam Farahmandfar Somayeh Ebrahimi-Barough Source Type: research

Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: Expression changes of NMDA receptor subunits and NT-3
This study was designed to discover the effect of MSCs injection in the nucleus accumbens (NAc) on the reinstatement of behavior in morphine-induced conditioned place preference (CPP) in male rats. The CPP was induced via intra-peritoneal (i.p.) morphine injection (5 mg/kg) for three consecutive days. After being tested for CPP induction, animals received MSCs or culture medium (DMEM F-12) in their NAc using stereotaxic surgery. Following extinction, a priming dose of morphine (2 mg/kg) was administered to induce reinstatement. Expression of GluN1, GluN2A, and GluN2B subunits of the NMDA receptor and the NT-3 gene in the N...
Source: Behavioural Brain Research - February 28, 2023 Category: Neurology Authors: Parviz Dousti Kataj Nasim Vousooghi Mahmoudreza Hadjighassem Maryam Farahmandfar Somayeh Ebrahimi-Barough Source Type: research

Transcatheter aortic valve replacement with or without anesthesiologist: results from a high-volume single center
Conclusion In patients at low or intermediate risk undergoing transfemoral TAVR, a safe procedure can be performed under local anesthesia without the presence of an anesthesiologist in the catheterization laboratory.
Source: Journal of Cardiovascular Medicine - November 12, 2022 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

Scientists develop blueprint for turning stem cells into sensory interneurons
Key takeaways:Just like the real thing.The stem cell –derived interneurons, which play a role in sensations like touch and pain, are indistinguishable from their real-life counterparts in the body.Tomorrow ’s therapies. In addition to potential treatments for injury-related sensation loss, the discovery could lead to new methods for screening drugs for chronic pain.Moving forward. While stem cells from mice were used in the research, scientists are now working to replicate the findings with human cells.Researchers at the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have develop...
Source: UCLA Newsroom: Health Sciences - July 19, 2022 Category: Universities & Medical Training Source Type: news

266 A drowsy patient: beyond the familiar territory
A 72-year-old man was brought to the hospital after he was found unresponsive at home by his wife who reported that he has been sleepy in the last few days. He has a background of hypertension, myocardial infarct, and osteoarthritis. His medications include anti-hypertensive and morphine sulphate. On examination, he was drowsy with GCS fluctuating between 9–11 but maintaining his airways. He was moving all four limbs; pupils were small and unequal but reactive to light. Planter reflexes were downgoing. Opioid toxicity was suspected and treated with naloxone without any response. The CT head scan showed no acute patho...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Oo, A., Khine, N. Tags: Poster Presentations Source Type: research

Cardiac failure in a child with tuberculous meningitis as a complication of Paroxysmal sympathetic hyperactivity
CONCLUSIONS: PSH assessment tool has benefits such as monitoring the patient, evaluating response to treatment and early diagnosing PSH patients.PMID:35611428 | DOI:10.24953/turkjped.2020.3609
Source: The Turkish Journal of Pediatrics - May 25, 2022 Category: Pediatrics Authors: P ınar Yazıcı Özkaya E şe Eda Turanlı Hatice Feray Ar ı Serap Kurt B ülent Karapınar Source Type: research

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