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Drug: Nifedipine

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Total 31 results found since Jan 2013.

Clinical Reasoning: A 43-year-old woman with right limb weakness
A 43-year-old woman presented with a 4-day history of right limb weakness. While biking 4 days earlier, she felt a weakness in her right hand and leg. She had a history of hypertension for more than 2 years, and was taking extended-release nifedipine tablets (40 mg) and perindopril (4 mg) daily, but her blood pressure was difficult to control (fluctuations of 150–180/90–115 mm Hg). The patient did not smoke or drink alcohol, and had no family history of similar diseases.
Source: Neurology - March 19, 2017 Category: Neurology Authors: Li, S., Zhang, J., Liu, P., Wei, R., Yuan, H., Ke, Q. Tags: Stroke in young adults RESIDENT AND FELLOW SECTION Source Type: research

Long-term outcomes of lercanidipine versus other calcium channel blockers in newly-diagnosed hypertension: a nationwide cohort study.
CONCLUSION: In newly diagnosed patients with hypertension, lercanidipine was superior than nifedipine in the six-year period when the analyzed endpoint was stroke. PMID: 28300435 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - March 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Therapeutic Differences in 24 ‐h Ambulatory Blood Pressures in Patients Switched Between Bioequivalent Nifedipine Osmotic Systems With Differing Delivery Technologies
This study examined the validity of the assumption that these interchangeable, but different, delivery technologies are therapeutically equivalent in maintaining systolic blood pressure (SBP) control throughout the entire dosing interval. We used 24‐h Ambulatory Blood Pressure Monitoring to objectively examine whether formulation switches changed population SBP >2 mmHg (reflecting 6% increased stroke mortality) and in what proportion of patients SBP changed ≥6 mmHg (risking unnecessary therapeutic alterations). When 20 patients, previously receiving 60‐mg‐once‐daily Nifedipine‐GITS, were switched to Mylan‐...
Source: Clinical and Translational Science - February 23, 2017 Category: Biomedical Science Authors: PT Pollak, RJ Herman, RD Feldman Tags: ARTICLE Source Type: research

Longitudinal hemodynamics in acute phase of treatment with labetalol in hypertensive pregnant women to predict need for vasodilatory therapy
ConclusionMaternal demographics and hemodynamic changes in the acute phase of labetalol monotherapy provide a powerful tool to identify hypertensive pregnant patients who are unlikely to have their BP controlled by this therapy and will consequently need additional vasodilatory therapy. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Source: Ultrasound in Obstetrics and Gynecology - November 30, 2016 Category: Radiology Authors: D. Stott, M. Bolten, D. Paraschiv, I. Papastefanou, J. B. Chambers, N. A. Kametas Tags: Original Paper Source Type: research

Safety of Immediate-Release Nifedipine
Abstract: Nifedipine immediate release (IR) is a short-acting dihydropyridine calcium channel blocker historically used for hypertensive crisis, but its use has decreased because of reports of adverse reactions such as myocardial infarction (MI), arrhythmias, and stroke. This was a retrospective evaluation of the safety of nifedipine IR in 122 patients at an academic medical center from January 1, 2009, to December 31, 2014. Patients were separated into high- and low-risk groups. High risk was defined as a medical history significant for arrhythmia, MI, or stroke. The primary outcome was a comparison of the composite incid...
Source: Journal of Cardiovascular Pharmacology - November 1, 2016 Category: Cardiology Tags: Rapid Communication Source Type: research

Pattern of antihypertensive therapy among diabetic hyperten- sive patients in zewditu memorial hospital, addis ababa.
CONCLUSION: The pattern of antihypertensive drug therapy in our patients was consistent with the current treatment guidelines. However, the majority of diabetic-hypertensive patients did not reach target blood pressure. PMID: 27476227 [PubMed - in process]
Source: Ethiopian Medical Journal - August 3, 2016 Category: African Health Tags: Ethiop Med J Source Type: research

Design, synthesis, and negative inotropic evaluation of 4 ‐phenyl‐1H‐1,2,4‐triazol‐5(4H)‐one derivatives containing triazole or piperazine moieties
This article is protected by copyright. All rights reserved. Four novel series of 4‐phenyl‐1H‐1,2,4‐triazol‐5(4H)‐one derivatives containing triazole or piperazine moieties were designed, synthesized, and evaluated for negative inotropic activity. The cytotoxicity of these compounds was evaluated and a preliminary investigation of the mechanism of action of these compounds on the atrial dynamics was also conducted.
Source: Chemical Biology and Drug Design - July 28, 2016 Category: Biology Authors: Zhi ‐Yu Wei, Bai‐Ri Cui, Xun Cui, Yan‐Ling Wu, Yang Fu, Li‐Ping Liu, Hu‐Ri Piao Tags: Research Article Source Type: research

Prognostic importance of pretreatment and on-treatment blood pressure: Further analysis of the ACTION database and the effect of nifedipine gastrointestinal therapeutic system.
Authors: Elliott HL, Lloyd SM, Ford I, Meredith PA Abstract This retrospective further analysis of the ACTION database evaluated the relationships between baseline blood pressure (BP), on-treatment BP (after 6 weeks) and subsequent cardiovascular outcomes. Analyses were performed using multivariate Cox proportional hazard models. Statistically significant (p < 0.001) and consistent patterns were noted between the risk of major cardiovascular endpoints and both baseline SBP and on-treatment SBP. The lowest risk of debilitating stroke was apparent in those patients with baseline SBP < 120mmHg, with a ha...
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research

Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study
In this study, 5857 patients received coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. There were no differences in comorbidity or use of antihypertensive drugs between patients who received CYP3A4-metabolized statins and those who received non-CYP3A4-metabolized statins. Patients who received CYP3A4-metabolized statins had significantly higher risk of acute kidney injury (adjusted odds ratio [OR] = 2.12; 95% CI = 1.35–3.35), hyperkalemia (adjusted OR = 2.94; 95% CI = 1.36–6.35), acute myocardial infarction (adjusted OR = 1.55; 95% CI = 1.16–2.07), and acute ischemic ...
Source: Medicine - January 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Prevalence of hypertension and its treatment among adults presenting to primary health clinics in rural Zambia: analysis of an observational database
Conclusions: Age standardized prevalence of hypertension in rural primary health clinics in Zambia was high compared to other studies in rural Africa; however, we diagnosed hypertension with only one measurement and this may have biased our findings. Future efforts to improve hypertension control should focus on population preventive care and primary healthcare provider education on individual management.
Source: BMC Public Health - September 21, 2015 Category: Consumer Health News Authors: Lily YanBenjamin ChiNtazana SindanoSamuel BosomprahJeffrey StringerRoma Chilengi Source Type: research

O60. Treatment of hypertension in pregnancy
Conclusions According to recent guidelines, in the absence of randomised clinical trials recommendations how hypertension should be treated in pregnant women, can only be guided by experts’ opinion based on case reports and their meta-analyses.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 31, 2015 Category: OBGYN Source Type: research

Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: a systematic review.
CONCLUSIONS: Oral nifedipine, and possibly labetalol and methyldopa, are suitable options for treatment of severe hypertension in pregnancy/postpartum. PMID: 24832366 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 16, 2014 Category: OBGYN Authors: Firoz T, Magee L, MacDonell K, Payne B, Gordon R, Vidler M, von Dadelszen P, the Community Level Interventions for Pre-eclampsia (CLIP) Working Group Tags: BJOG Source Type: research

Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: a systematic review
ConclusionsOral nifedipine, and possibly labetalol and methyldopa, are suitable options for treatment of severe hypertension in pregnancy/postpartum.
Source: BJOG: An International Journal of Obstetrics and Gynaecology - May 16, 2014 Category: OBGYN Authors: T Firoz, LA Magee, K MacDonell, BA Payne, R Gordon, M Vidler, P Dadelszen, Tags: Systematic Review Source Type: research

Emodin accentuates atrial natriuretic peptide secretion in cardiac atria.
Abstract Emodin, an active anthraquinone constituent isolated from the rhubarb, a traditional Chinese herbal medicine which is widely used in clinical treatment, has cardiovascular protective properties. However, it remains unclear whether the cardiovascular protective actions of emodin are related to an activation of cardiac natriuretic hormone secretion. The purpose of the present study was to explore the effect of emodin on the secretion of ANP, a member of the family of cardiac natriuretic hormones, and its mechanisms involved. Experiments were performed in isolated perfused beating rabbit atria allowing measu...
Source: European Journal of Pharmacology - April 18, 2014 Category: Drugs & Pharmacology Authors: Hai Zhou G, Zhang F, Nong Wang X, Jeong Kwon O, Gill Kang D, Sub Lee H, Nan Jin S, Woo Cho K, Fu Wen J Tags: Eur J Pharmacol Source Type: research

Abstract 70: Eplerenone Increases Dilation and the Diameter of Cerebral Penetrating Arterioles in Rats with Sustained Hypertension Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones
Hypertension is linked to dementia in humans, as well as remodeling and dysfunction in large cerebral arteries. The effects of hypertension on cerebral microvessels, such as penetrating arterioles (PenA), are still unknown. These arterioles are the bottlenecks bridging the pial circulation to the deep parenchymal microcirculation, and they are vital for neurovascular coupling and functional hyperemia. Mineralocorticoid receptor (MR) antagonism reverses hypertension-induced changes in large cerebral arteries. Thus, we hypothesized that MR antagonism will improve PenA dilation and structure in adult rats with sustained hyper...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Pires, P. W., Jackson, W. F., Dorrance, A. M. Tags: Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones Source Type: research