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Total 29 results found since Jan 2013.

Dissection-related tandem occlusion may be different from atherothrombotic tandem occlusion
The optimal endovascular treatment for tandem occlusion in anterior circulation ischaemic stroke remains unknown. The aim of this study was to examine how the aetiology of carotid pathology, dissection versus atherothrombosis, affects clinical outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2022 Category: Neurology Authors: Liqun Zhang, Sarah Trippier, Soma Banerjee, Tian Xu, Joe Leyon, Eleanor Taylor, Anan Shtaya, Cai Hua Sim, Sergios Gargalas, Usman Khan, Gillian Cluckie, Peter Holt, Kyriakos Lobotesis, Andrew Clifton, Hugh S Markus, Mayank Goyal, Ayokunle Ogungbemi Tags: Short Communication Source Type: research

Intracranial Pressure Dysfunction Following Severe Intracerebral Hemorrhage in Middle-Aged Rats
Transl Stroke Res. 2022 Nov 11. doi: 10.1007/s12975-022-01102-8. Online ahead of print.ABSTRACTRising intracranial pressure (ICP) aggravates secondary injury and heightens risk of death following intracerebral hemorrhage (ICH). Long-recognized compensatory mechanisms that lower ICP include reduced cerebrospinal fluid and venous blood volumes. Recently, we identified another compensatory mechanism in severe stroke, a decrease in cerebral parenchymal volume via widespread reductions in cell volume and extracellular space (tissue compliance). Here, we examined how age affects tissue compliance and ICP dynamics after severe IC...
Source: Cell Research - November 11, 2022 Category: Cytology Authors: Anna C J Kalisvaart Ashley H Abrahart Alyvia T Coney Sherry Gu Frederick Colbourne Source Type: research

Time Efficient Multi-Pulsed Field Gradient (mPFG) MRI Without Concomitant Gradient Field Artifacts
Measuring and mapping nervous tissue microstructure noninvasively is a long sought-after goal in neuroscience. Clinically, several neuropathologies such as cancer and stroke, are associated with changes in tissue microstructure. Diffusion tensor imaging (DTI), which models diffusion anisotropy, is an ideal imaging modality to elucidate these changes. However, DTI provides a mean diffusion tensor averaged over the entire MRI voxel. This has limitations when applied to heterogeneous neural tissue. Although some of these could be overcome by increased spatial resolution, this comes at the cost of reduced signal-to-noise ratio...
Source: NIH OTT Licensing Opportunities - May 10, 2022 Category: Research Authors: ott8admin Source Type: research

Young-onset stroke complicating ulcerative colitis
Pract Neurol. 2022 Jan 7:practneurol-2021-003106. doi: 10.1136/practneurol-2021-003106. Online ahead of print.ABSTRACTA 16-year-old girl developed a proximal occlusion of the right middle cerebral artery during a flare-up of acute ulcerative colitis. Although mechanical thrombectomy led to successful middle cerebral artery recanalisation, she required an immediate second thrombectomy due to reocclusion of the same arterial segment. She developed a second ischaemic event 7 days later despite intravenous heparin infusion, later switched to low-molecular-weight heparin, and a third event after 3 days despite the addition of a...
Source: Practical Neurology - January 8, 2022 Category: Neurology Authors: Su Yin Lim Mohamed Sayed Soma Banerjee Neil Rane Dheeraj Kalladka Source Type: research

What have antidepressants been tested for? A systematic review.
CONCLUSIONS: Trials of antidepressants may be driven mainly by commercial interests, focusing on prevalent diseases and everyday problems. No one can live a full life without experiencing several of the problems for which these drugs were tested. Antidepressants, sometimes called happy pills, could be seen as the modern version of Aldous Huxley's soma pill intended to keep everyone happy in the "Brave New World". PMID: 32444565 [PubMed - as supplied by publisher]
Source: International Journal of Risk and Safety in Medicine - May 25, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Automated Continuous Electrocardiogram Monitoring Accelerates the Detection of Atrial Fibrillation after Ischemic Stroke or Transient Ischemic Attack on a Hyper Acute Stroke Unit
Background and Aim: Rapid and sensitive detection of atrial fibrillation (AF) is of paramount importance for initiation of adequate preventive therapy after stroke. Stroke Unit care includes continuous electrocardiogram monitoring (CEM) but the optimal exploitation of the recorded ECG traces is controversial. In this retrospective single-center study, we investigated whether an automated analysis of continuous electrocardiogram monitoring (ACEM), based on a software algorithm, accelerates the detection of AF in patients admitted to our Stroke Unit compared to the routine CEM.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2020 Category: Neurology Authors: Lucio D'Anna, Arindam Kar, Zoe Brown, Kirsten Harvey, Soma Banerjee, Eleni Korompoki, Roland Veltkamp Source Type: research

Clinical Study of Thirteen Patients with Spinal Cord Infarction
A concept of sensory tracts in the spinal cord has been established in relation to a dorsolateral pathway which is located in the posterior part of the lateral column and conveys the deep sense.
Source: Journal of Stroke and Cerebrovascular Diseases - September 30, 2019 Category: Neurology Authors: Katsuhiko Ogawa, Takayoshi Akimoto, Makoto Hara, Akihiko Morita, Midori Fujishiro, Yutaka Suzuki, Masayoshi Soma, Satoshi Kamei, Hideto Nakajima Source Type: research

Intravenous Thrombolysis and Mechanical Thrombectomy in Patients with Stroke after TAVI: A Report of Two Cases
We describe 2 cases of patients with stroke after TAVI who received tPA therapy and mechanical thrombectomy.
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2019 Category: Neurology Authors: Lucio D'Anna, Ozan Demir, Soma Banerjee, Iqbal Malik Tags: Case Report Source Type: research

Alternating Amaurosis Fugax in Trousseau Syndrome: A Case Report
Amaurosis fugax (AmF) is defined as transient monocular visual loss secondary to retinal ischemia. In most patients presenting with AmF, the attack of visual loss occurs in the same eye. A 64-year-old woman experienced transient visual loss in her right eye. Three days after that, an attack happened on the left side. In total, she had 5 episodes of AmF in 2 months. AmF occurred on both sides at different times, and so may be referred to as “Alternating AmF”. Diffusion-weighted magnetic resonance imaging showed high-intensity lesions in various parts of brain, and laboratory examination revealed elevated D-dimer and ovarian tumor marker.
Source: Journal of Stroke and Cerebrovascular Diseases - May 12, 2019 Category: Neurology Authors: Katsuhiko Kunitake, Ryosuke Inagaki, Soma Furukawa, Satoshi Kitagawa, Hidenori Oguchi, Yasuhiro Ito Tags: Case Report Source Type: research

Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury
Conclusion and Future Aspects This review summarizes available NTF expression data, compiles existing evidence on the effects of glial NTF signaling in healthy conditions and in disease models (Figure 1), and highlights the importance of this topic for future studies. The relationship between NTFs and glia is crucial for both the developing and adult brain. While some of these factors, such as NT-3 and CNTF, have highly potent effects on gliogenesis, others like BDNF and GDNF, are important for glia-mediated synapse formation. Neurotrophic factors play significant roles during neurodegenerative disorders. In many cases, ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Risk Factors for Major Adverse Cardiovascular Events in Phase III and Long ‐Term Extension Studies of Tofacitinib in Patients with Rheumatoid Arthritis
ConclusionIn this post ‐hoc analysis, after 24 weeks of tofacitinib, increased HDL‐c, but not increases in LDL‐c or TC, appeared to be associated with lower future MACE risk. Further data are needed to test the cardiovascular safety of tofacitinib.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - April 16, 2019 Category: Rheumatology Authors: Christina Charles ‐Schoeman, Ryan DeMasi, Hernan Valdez, Koshika Soma, Lie‐Ju Hwang, Mary G. Boy, Pinaki Biswas, Iain B. McInnes Tags: Full Length Source Type: research