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Total 253 results found since Jan 2013.

A Novel Approach to the Treatment of Orolingual Angioedema After Tissue Plasminogen Activator  Administration
Publication date: September 2016 Source:Annals of Emergency Medicine, Volume 68, Issue 3 Author(s): Lesley Pahs, Chris Droege, Hilary Kneale, Arthur Pancioli Orolingual angioedema is a rare adverse effect of tissue plasminogen activator (tPA), with an incidence of 1% to 5%. There are currently no published reports describing resolution of tPA-induced orolingual angioedema with complement inhibitor therapy. A 72-year-old man receiving home angiotensin-converting enzyme inhibitor therapy presented to the emergency department with newly developed orolingual angioedema after treatment with tPA for acute ischemic stroke. Thera...
Source: Annals of Emergency Medicine - August 24, 2016 Category: Emergency Medicine Source Type: research

A severe, relapsing case of myelin oligodendrocyte glycoprotein IgG-associated CNS inflammation
A 55-year-old man presented in October 2004 with general unease, vomiting, and gait disturbance. Initially diagnosed with an inner ear infection, the patient's symptoms did not improve and he was evaluated further. MRI revealed a cerebellar lesion, which led to the suspicion of a posterior circulation stroke, and he was started on antiplatelet drugs. However, an angiogram suggested no vascular pathology. In March 2011, he had another episode of ataxia and MRI showed a right brainstem lesion. Cryptogenic stroke was reconsidered. In March 2013, the patient developed paraparesis with urinary and bowel symptoms. MRI revealed m...
Source: Neurology Clinical Practice - February 12, 2018 Category: Neurology Authors: Saviour, M., Hamid, S., Moore, P., Mutch, K., Bhojak, M., Duddy, M., Jacob, A. Tags: All Demyelinating disease (CNS), Devic's syndrome, Optic neuritis; see Neuro-ophthalmology/Optic Nerve, Transverse myelitis Case Source Type: research

Case Report: A Spinal Ischemic Lesion in a 24-Year-Old Patient With Fabry Disease
ConclusionThe current case highlights the possible occurrence of spinal ischemic lesions in FD. Thus, the diagnosis of FD should not be prematurely discarded in the presence of spinal lesions.
Source: Frontiers in Immunology - December 14, 2020 Category: Allergy & Immunology Source Type: research

Diagnostic Value of Vessel Wall Imaging to Determine the Timing of Extracranial ‒Intracranial Bypass for Moyamoya Syndrome Associated with Active Sjögren's Syndrome: A Case Report
Conclusions Our findings emphasize the diagnostic value of contrast-enhanced MR-VWI in monitoring the effect of immunosuppressive therapy for the major cerebral artery vasculitis and in determining the timing of EC–IC bypass as a “rescue” treatment for moyamoya syndrome associated with active Sjögren's syndrome. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - May 23, 2023 Category: Neurosurgery Authors: Shindo, Takafumi Ito, Masaki Sugiyama, Taku Okuyama, Tomohiro Kono, Michihito Atsumi, Tatsuya Fujimura, Miki Tags: Case Report Source Type: research

Granulomatous angiitis of the CNS revealing a Hodgkin lymphoma
Apart from the iatrogenic effects of treatment, neurologic complications of Hodgkin lymphoma (HL) can be divided into direct (meningeal or intracranial/spinal localization) and indirect (paraneoplastic/immune complications).1 Here, we present a patient with granulomatous angiitis of the CNS (GANS) associated with HL that dramatically improved after the treatment of the angiitis by cyclophosphamide, methylprednisolone, and specific chemotherapy.
Source: Neurology - January 14, 2013 Category: Neurology Authors: Le Guennec, L., Roos-Weil, D., Mokhtari, K., Chauvet, D., Psimaras, D., Reiner, P., Demeret, S., Bolgert, F., Choquet, S., Weiss, N. Tags: MRI, Other cerebrovascular disease/ Stroke, All Medical/Systemic disease, Coma, All Oncology, Class IV CLINICAL/SCIENTIFIC NOTES Source Type: research

Different methods of immunosuppresion do not prolong the survival of human cord blood-derived neural stem cells transplanted into focal brain-injured immunocompetent rats.
Abstract Cerebrovascular diseases are the leading cause of severe disability worldwide, with an enormous financial burden for society. There is growing evidence that stem cell-based therapy may positively influence recovery from stroke. Cord blood is an attractive source of ontogenetically young, yet safe, stem cells. Conceptually, preclinical studies in which donor cells were of human origin have been the most valuable, and thus, it is likely that these cells will be used in clinical trials. Unfortunately, immunological barriers impede discordant xenotransplantations. We have previously observed acute rejection o...
Source: Acta Neurobiologiae Experimentalis - May 25, 2013 Category: Neurology Authors: Jablonska A, Janowski M, Lukomska B Tags: Acta Neurobiol Exp (Wars) Source Type: research

Anti glutamic acid decarboxylase antibody mediated encephalopathy while on etanercept in a patient with multiple autoimmune diseases
A 39 year old lady presented with an altered mental state and unsteadiness of gait. She had a history of juvenile idiopathic arthritis, autoimmune thyroiditis and alopecia, protein S deficiency with vena cava thrombosis, previous excision of ovarian mass and vasculitic rash. There was a previous history of ovarian mass and her immunomodulatory therapy for arthritis over the previous year was Etanercept. She used recreational cannabis but denied any other illicit drug usage. Her affect was variable and at times inappropriate with frequent laughter. She would spit regularly. There was anxiety and a prevailing sensation of do...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: MacDougall, N., Waddell, B., O'Riordan, J. I. Tags: Immunology (including allergy), Brain stem / cerebellum, Drugs: CNS (not psychiatric), Epilepsy and seizures, Infection (neurology), Stroke, Drugs misuse (including addiction), Connective tissue disease, Musculoskeletal syndromes Association of British Source Type: research

Acute disseminated encephalomyelitis associated with dengue infection: A case report with literature review
Abstract: Dengue is the commonest arboviral illness caused by four antigenically distinct dengue virus serotypes (DEN-1 through DEN-4). The clinical spectrum of the disease ranges from asymptomatic or mild infection to catastrophic dengue shock syndrome (DSS). In last few years, neurological manifestations of dengue infection have been increasingly observed and reported mainly with serotypes DEN-2 and DEN-3. The pathogenesis of neurological manifestations includes: neurotrophic effect of the dengue virus, related to the systemic effects of dengue infection, and immune mediated. Encephalopathy and encephalitis are the most ...
Source: Journal of the Neurological Sciences - September 16, 2013 Category: Neurology Authors: Meena Gupta, Rajeev Nayak, Geeta A. Khwaja, Debashish Chowdhury Tags: Short Communications Source Type: research

Combined Treatment of Methylprednisolone Pulse and Memantine Hydrochloride Prompts Recovery from Neurological Dysfunction and Cerebral Hypoperfusion in Carbon Monoxide Poisoning: A Case Report
A 49-year-old healthy man developed sudden unconsciousness under inadequate ventilation. Blood gas analysis showed carboxyhemoglobin of 7.3%. After normobaric oxygen therapy, he recovered completely 7 days later. At 3 weeks after carbon monoxide (CO) exposures, memory and gait disturbances appeared. Neurological examination revealed Mini-Mental State Examination (MMSE) score of 5 of 30 points, leg hyper-reflexia with Babinski signs, and Parkinsonism. Brain fluid-attenuated inversion recovery imaging disclosed symmetric hypointense lesions in the thalamus and the globus pallidus, and hyperintense lesions in the cerebral w...
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2013 Category: Neurology Authors: Konosuke Iwamoto, Ken Ikeda, Sunao Mizumura, Kazuhiro Tachiki, Masaru Yanagihashi, Yasuo Iwasaki Tags: Case Reports Source Type: research

Cerebral Varicella Zoster Vasculopathy Sine Herpete: Atypical Ramsay-Hunt Syndrome Presentation in an Immunocompetent Patient (P6.258)
CONCLUSIONS:VZV CNS vasculopathy may present with atypical clinical and CSF characteristics. Patients with suspected CNS vasculitis without pathological confirmation should be tested for this treatable condition, regardless of their immune status.Disclosure: Dr. Gonzalez Otarula has nothing to disclose. Dr. Bruno has nothing to disclose. Dr. Pujol-Lereis has nothing to disclose. Dr. Ameriso has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Gonzalez Otarula, K., Bruno, V., Pujol-Lereis, V., Ameriso, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Hashimoto's encephalopathy: Report of three cases
Publication date: November 2014 Source:Journal of the Formosan Medical Association, Volume 113, Issue 11 Author(s): Jan-Shun Chang , Tien-Chun Chang Both severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is known as Hashimoto's encephalopathy. Although most patients are found to have Hashimoto's thyroiditis, less frequently they have Graves' disease. Clinical manifestations include e...
Source: Journal of the Formosan Medical Association - November 9, 2014 Category: Journals (General) Source Type: research

The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease
We present the unique case of a pediatric patient who received chemotherapy for a diagnosis of CD, while mechanically supported with a Berlin EXCOR LVAD secondary to restrictive cardiomyopathy. A four‐yr‐old previously healthy male with restrictive cardiomyopathy required MCS after cardiac arrest but was diagnosed with multicentric CD, a non‐malignant lymphoproliferative disorder fueled by excessive IL‐6 production. Treatment with IL‐6 blockade (tocilizumab) every two wk and methylprednisolone had no effect on his lymph nodes or cardiac function while on temporary RotaFlow. A Berlin LVAD was placed for treatment...
Source: Pediatric Transplantation - December 1, 2014 Category: Transplant Surgery Authors: Tamara O. Thomas, Shanmuganathan Chandrakasan, Maureen O'Brien, John L. Jefferies, Thomas D. Ryan, Ivan Wilmot, Michael L. Baker, Peace C. Madueme, David Morales, Angela Lorts Tags: Case Report Source Type: research

Hashimoto's encephalopathy: Report of three cases.
Abstract Both severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is known as Hashimoto's encephalopathy. Although most patients are found to have Hashimoto's thyroiditis, less frequently they have Graves' disease. Clinical manifestations include epilepsy, disturbance of consciousness, cognitive impairment, memory loss, myoclonus, hallucinations, stroke-like episodes, tremor, in...
Source: J Formos Med Assoc - November 1, 2014 Category: Journals (General) Authors: Chang JS, Chang TC Tags: J Formos Med Assoc Source Type: research

Digital Subtraction Angiography (DSA) Arch Run in Place of CT Vessel and Perfusion Imaging: Proof of Concept (P1.014)
CONCLUSIONS: In both cases, DSA arch runs generated adequate, rapid vessel imaging including demonstration of collaterals in place of CTA/CTP. This minimized delays in treatment, provided information key to predicting benefit and facilitated a shorter time to reperfusion. This is proof of concept, that DSA arch runs can be used in place of CTA/CTP in patients likely to require intra-arterial therapy.Disclosure: Dr. Campbell has nothing to disclose. Dr. Jadhav has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Campbell, D., Jadhav, A. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research

Spinal Cord Infarction as the Initial Presentation of Systemic Lupus Erythematosus (P2.077)
CONCLUSIONS:Aggressive therapy with high dose corticosteroids and intravenous cyclophosphamide followed by oral therapy may be a successful therapeutic approach to spinal cord infarcts secondary to systemic lupus erythematosus. Study Supported by: N/ADisclosure: Dr. Michael has nothing to disclose. Dr. Hayat has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Michael, A., Hayat, G. Tags: Neurological Consequences of Autoimmune Disease Source Type: research