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Drug: Methylprednisolone

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Total 253 results found since Jan 2013.

Primary Angiitis of the Central Nervous System (PACNS) Presenting with Intracerebral Hemorrhage (P2.293)
Conclusion: Primary CNS vasculitis should be suspected even in patients presenting initially with intracerebral hemorrhage in association with only moderate headaches.Disclosure: Dr. Alkhalifah has nothing to disclose. Dr. Fayad has received research support from the National Institute of Neurological Disorders and Stroke and St. Jude Medical. Dr. Omojola has nothing to disclose. Dr. Hearth-Holmes has nothing to disclose. Dr. McComb has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Alkhalifah, M., Fayad, P., Omojola, M., Hearth-Holmes, M., McComb, R. Tags: Cerebrovascular Disease and Interventional Neurology: Inflammation and Immunology Source Type: research

Estimated deaths and illnesses averted during fungal meningitis outbreak associated with contaminated steroid injections, United States, 2012-2013.
Abstract During 2012-2013, the US Centers for Disease Control and Prevention and partners responded to a multistate outbreak of fungal infections linked to methylprednisolone acetate (MPA) injections produced by a compounding pharmacy. We evaluated the effects of public health actions on the scope of this outbreak. A comparison of 60-day case-fatality rates and clinical characteristics of patients given a diagnosis on or before October 4, the date the outbreak was widely publicized, with those of patients given a diagnosis after October 4 showed that an estimated 3,150 MPA injections, 153 cases of meningitis or st...
Source: Emerging Infectious Diseases - May 22, 2015 Category: Infectious Diseases Authors: Smith RM, Derado G, Wise M, Harris JR, Chiller T, Meltzer MI, Park BJ Tags: Emerg Infect Dis Source Type: research

Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial
This study is registered with ClinicalTrials.gov, number NCT00427388. Findings Patients were recruited between June 21, 2007, and Dec 19, 2013. Complete 30-day data was available for all 7507 patients randomly assigned to methylprednisolone (n=3755) and to placebo (n=3752). Methylprednisolone, compared with placebo, did not reduce the risk of death at 30 days (154 [4%] vs 177 [5%] patients; relative risk [RR] 0·87, 95% CI 0·70–1·07, p=0·19) or the risk of death or major morbidity (909 [24%] vs 885 [24%]; RR 1·03, 95% CI 0·95–1·11, p=0·52). The most common safety outcomes in the methylprednisolone and placebo g...
Source: The Lancet - September 26, 2015 Category: Journals (General) Source Type: research

Intracerebral hemorrhage with a favorable outcome in a patient with childhood primary angiitis of the central nervous system
We present the case of a boy with cPACNS that previously suffered an ischemic stroke. At the age of 7 years and 10 months, he presented a sudden and severe headache, vomiting and reduction in consciousness level (Glasgow coma scale 7), requiring prompt tracheal intubation. Brain computed tomography demonstrated intraparenchymal hematoma in the right parieto-occipital lobe and a small focus of bleeding in the right frontal lobe, vasogenic edema, herniation of the uncus and a 10mm deviation to the left from the midline. C-reactive protein (9.2mg/dL) and von Willebrand factor (vWF) antigen (202%) were elevated. Decompressive ...
Source: Revista Brasileira de Reumatologia - December 1, 2015 Category: Rheumatology Source Type: research

Multiple cerebral and cerebellar infarcts as the first clinical manifestation in a patient with Churg-Strauss syndrome: case report and literature review.
CONCLUSION: Symptoms and signs of central nervous system can be the initial neurological manifestation of CSS patients. CSS should be considered while patients have stroke and hypereosinophilia. In our patient, there is a good response to timely steroid, immunosuppressant and anticoagulant therapies. PMID: 23329548 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Non-traumatic Cerebral Fat Embolism in Sickle Cell Disease (P3.234)
Conclusions:Our case series illustrates the following clinical pearls: a) SCD-related CFES is vastly under-diagnosed, as it closely mimics sepsis, vasculitis or hypoxic ischemic encephalopathy; b) The diagnosis is confirmed with SWI that demonstrates pathognomonic microbleeds in the splenium and subcortical location; c) SCD-related CFES carries considerable morbidity and mortality.Disclosure: Dr. Ramachandiran has nothing to disclose. Dr. Raniga has nothing to disclose. Dr. Al Kindi has nothing to disclose. Dr. Dennison has nothing to disclose. Dr. Al Farsi has nothing to disclose. Dr. Al Busaidi has nothing to disclose. D...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ramachandiran, N., Raniga, S., Al Kindi, S., Dennison, J., Al Farsi, K., Al Busaidi, M., Al Hashim, A., Al Azri, F., Gujjar, A., Al-Asmi, A. Tags: Stroke in the Young Source Type: research

Neurological complications of acute multifocal placoid pigment epitheliopathy
The objective of this patient series is to describe the neurological complications of AMPPE. We retrospectively identified patients with neurological complications of AMPPE seen at Auckland Hospital between 2008 and 2013 and summarised cases in the literature between 1976 and 2013. We identified five patients with neurological complications of AMPPE at Auckland Hospital and 47 reported patients. These patients demonstrated a spectrum of neurological involvement including isolated headache, stroke or transient ischaemic attack, seizures, venous sinus thrombosis, optic neuritis, sensorineural hearing loss and peripheral vest...
Source: Journal of Clinical Neuroscience - May 11, 2016 Category: Neuroscience Source Type: research

Intracerebral hemorrhage with a favorable outcome in a patient with childhood primary angiitis of the central nervous system
We present the case of a boy with cPACNS that previously suffered an ischemic stroke. At the age of 7 years and 10 months, he presented a sudden and severe headache, vomiting and reduction in consciousness level (Glasgow coma scale 7), requiring prompt tracheal intubation. Brain computed tomography demonstrated intraparenchymal hematoma in the right parieto-occipital lobe and a small focus of bleeding in the right frontal lobe, vasogenic edema, herniation of the uncus and a 10 mm deviation to the left from the midline. C-reactive protein (9.2 mg/dL) and von Willebrand factor (vWF) antigen (202%) were elevated. Decompressiv...
Source: Revista Brasileira de Reumatologia - August 22, 2016 Category: Rheumatology Source Type: research

Acute spinal cord syndrome secondary to venous congestion
A 13-year-old boy developed lower limb flaccid paralysis 24 hours after accidental ingestion of an odorless and tasteless potassium hydroxide liquid. He had absent abdominal reflexes, brisk deep tendon reflexes, and no sensation distal to the umbilicus. MRI demonstrated T2 hyperintensities throughout the spinal cord and engorgement of basilar vertebral venous plexus (figure). He made a full recovery within 48 hours of empirical IV methylprednisolone.
Source: Neurology - September 18, 2016 Category: Neurology Authors: Woodcock, I. R., Coscini, N., Mandelstam, S., Rodriguez-Casero, V., Dabscheck, G. Tags: MRI, Other cerebrovascular disease/ Stroke, All Pediatric, Spinal cord infarction, Other toxicology NEUROIMAGES Source Type: research

Case report: acute demyelinating encephalomyelitis following viper bite
We present a rarely seen central nervous system complication, acute demyelinating encephalomyelitis, after a treated Deinagkistrodon's viper bite. On April 5, 2015, a 50-year-old male farmer was bitten on his right leg by a Deinagkistrodon's viper. The bite rendered the victim unconscious for 14 days, during which he was treated with tetanus toxoid and polyvalent antisnake venom. Acute demyelinating encephalomyelitis (ADEM) was suspected after magnetic resonance imaging of the brain. After a high dose of methylprednisolone was used as diagnostic treatment, the patient started recovering fast. ADEM is a rare complication ...
Source: Medicine - November 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Rapidly Progressive atypical Posterior Reversible Encephalopathy Syndrome (PRES) associated with B-cell lymphoma (P4.065)
Conclusions:This case illustrates a rapidly progressive clinicoradiological syndrome with remarkable radiographical features of atypical PRS, and association with diffuse B-cell lymphomaDisclosure: Dr. Bronstein has nothing to disclose. Dr. Danesh has nothing to disclose. Dr. Petrovic has nothing to disclose. Dr. Ashikian has nothing to disclose. Dr. Arbuckle has nothing to disclose. Dr. Homafar has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Bronstein, Y., Danesh, M., Petrovic, M., Ashikian, N., Arbuckle, R., Homafar, H. Tags: General Neurology: Vascular Neurology Source Type: research

Teaching NeuroImages: Takayasu arteritis: Neuroimaging progression after immunosuppressant treatment
A 29-year-old woman presented with a 2-year history of heel pain, constitutional symptoms, and increased acute phase reactants. CT and magnetic resonance (MR) angiography revealed a thickening of aortic walls and a thread-like appearance of bilateral subclavian and common carotid arteries. The findings were consistent with Takayasu arteritis (TA)1 and the patient was prescribed methylprednisolone, followed by azathioprine. Follow-up MR angiography, 6 years later, showed an important improvement with only a mild luminal narrowing of both common carotid arteries (figures 1 and 2, A and B). TA is a large-artery inflammatory d...
Source: Neurology - May 15, 2017 Category: Neurology Authors: Martinez Rodriguez, L., Caminal Montero, L., Pena Suarez, J., Garcia-Cabo Fernandez, C., Calleja Puerta, S. Tags: MRI, Vasculitis, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

Parvovirus B19 infection associated with hemolytic anemia and cranial polyneuropathy
AbstractParvovirus B19 (PB19) is a common, widespread, small, single-stranded DNA virus which has been linked with a broad spectrum of clinical illnesses, including a variety of neurological complications such as encephalitis, meningitis, myelitis, stroke, cerebellar ataxia, and neuropathy. The authors describe a case of PB19 infection associated with hemolytic anemia and cranial polyneuropathy involving the second and third cranial nerves in a 23-year-old immunocompetent woman. The diagnosis of acute PB19 infection was established with detection of positive DNA and anti-PB19 IgM antibodies in blood samples. Antigangliosid...
Source: Journal of NeuroVirology - August 22, 2017 Category: Neurology Source Type: research

Intra-arterial milrinone may differentiate fulminant RCVS from vasculitis
A 39-year-old woman taking a monoamine oxidase inhibitor presented with a 1-week history of severe non-thunderclap headache and visual field deficits. Brain CT showed infarcts in both parietal lobes, with narrowing of intracranial vessels on CT angiogram (figure 1), suggesting either vasculitis or reversible cerebral vasoconstriction syndrome (RCVS). Despite treatment with both methylprednisolone and nimodipine, she experienced progressive aphasia and right leg weakness. She underwent an urgent cerebral angiogram (figure 2), during which intra-arterial milrinone reversed both the vasoconstriction and its symptoms, thereby ...
Source: Neurology - September 4, 2017 Category: Neurology Authors: Laneuville, M., Ding, J., Shamy, M., Lum, C., Dowlatshahi, D. Tags: All Headache, Other cerebrovascular disease/ Stroke NEUROIMAGES Source Type: research

Refractory Mycoplasma pneumoniae pneumonia with concomitant acute cerebral infarction in a child: A case report and literature review
We present a 7-year-old boy with severe M pneumoniae pneumonia who developed impaired consciousness, aphasia, and reduced limb muscle power 7 days postadmission. Diagnoses: Mycoplasma pneumoniae pneumonia with concomitant acute cerebral infarction. Interventions: The patient recovered with aggressive antibiotic therapy, antiinflammation therapy with methylprednisolone, and gamma immunoglobulin and anticoagulation therapy with aspirin and low molecular weight heparin along with rehabilitation training. Outcomes: At 8 days postadmission, his consciousness was improved and at the 6-month follow-up visit, his muscle p...
Source: Medicine - March 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research