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Drug: Activase

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Total 1186 results found since Jan 2013.

Association between computed tomography perfusion and the effect of intravenous alteplase prior to endovascular treatment in acute ischemic stroke
ConclusionIn directly admitted patients with limited CTP-estimated ischemic core volumes who presented within 4.5 h after symptom onset, CTP parameters did not statistically significantly alter the treatment effect of IVT prior to EVT. Further studies are needed to confirm these results in patients with larger core volumes and more unfavorable baseline perfusion profiles on CTP imaging.
Source: Neuroradiology - March 8, 2023 Category: Radiology Source Type: research

Predictors of Early Neurological Improvement and Its Relationship to Thrombolysis Treatment and Long-Term Outcome in the WAKE-UP Study
Conclusion: Intravenous alteplase increases the odds of ENI in patients with at least moderate stroke severity, especially when given early. In patients with large-vessel occlusion, ENI is rarely observed without thrombectomy. ENI represents a good surrogate early marker of treatment effect as more than a third of good outcome at 90 days is explained by ENI at 24 h.Cerebrovasc Dis
Source: Cerebrovascular Diseases - March 2, 2023 Category: Neurology Source Type: research

Effect of direct endovascular treatment versus standard bridging therapy in large artery anterior circulation stroke (DEVT): 18-month follow-up of a randomized controlled trial
We reporte...
Source: BMC Neurology - February 27, 2023 Category: Neurology Authors: Zhongfan Ruan, Xiaojun Luo, Yongkang Liu, Fengli Li, Jincheng Liu and Wenjie Zi Tags: Research Source Type: research

Low-dose vs. standard-dose alteplase for Chinese patients with acute ischemic stroke: A propensity score analysis
ConclusionsLow-dose alteplase was related to a poor functional outcome without lowering the risk of sICH, compared with standard-dose alteplase for AIS patients in China.
Source: Frontiers in Neurology - February 21, 2023 Category: Neurology Source Type: research

Age gap between stroke patients included in randomized clinical trials of acute revascularization therapy and those in population-based studies. A review
Background: The ongoing aging population in high-income countries is responsible for a dramatic rise in the number of elderly stroke patients in whom many questions remain regarding the use of acute revascularization therapy. This review aimed to compare stroke patients from population-based studies to those included in RCTs in terms of age. Summary: Population-based incidence studies conducted in high income that complied with the defined quality criteria were reviewed (period 1985-2020). RCTs of acute ischemic stroke therapy including intravenous thrombolysis (IVT) with either alteplase or tenecteplase and mechanical th...
Source: Neuroepidemiology - February 15, 2023 Category: Epidemiology Source Type: research

Cost-effectiveness of thrombectomy alone versus alteplase before thrombectomy in acute ischemic stroke: results from the DIRECT-MT
CONCLUSIONS: In this economic analysis based on a trial conducted in China, the authors found that EVT alone was not associated with economic dominance over EVT+IVT in patients with anterior circulation large-vessel occlusion.PMID:36790013 | DOI:10.3171/2022.12.JNS221791
Source: Journal of Neurosurgery - February 15, 2023 Category: Neurosurgery Authors: Hongyu Ma Yu Zhou Lan Gao Pei Liu Lei Zhang Pengfei Xing Zifu Li Hongjian Shen Hongjian Zhang Yongxin Zhang Xiaoxi Zhang Weilong Hua Yongwei Zhang Jianmin Liu Congguo Yin Pengfei Yang Direct-MT investigators Source Type: research

Perceived acceptable uncertainty regarding comparability of endovascular treatment alone versus intravenous thrombolysis plus endovascular treatment
Conclusion Physicians would generally feel comfortable skipping IVT before EVT at different certainty thresholds. Most physicians would treat with EVT alone if randomized trial data suggested that the number of patients achieving functional independence at 90 days was similar between the two groups, and one could be sufficiently sure that no more than 3 out of 100 patients would not achieve functional independence at 90 days due to skipping IVT.
Source: Journal of NeuroInterventional Surgery - February 14, 2023 Category: Neurosurgery Authors: Kaesmacher, J., Mujanovic, A., Treurniet, K., Kappelhof, M., Meinel, T. R., Yang, P., Liu, J., Zhang, Y., Zi, W., Yang, Q., Nogueira, R. G., Kimura, K., Matsumaru, Y., Suzuki, K., Yan, B., Mitchell, P. J., Miao, Z., Roos, Y. B. W. E. M., Majoie, C. B. L. Tags: Open access, Ischemic stroke Source Type: research

Tenecteplase Noninferior to Alteplase for Ischemic Stroke: TRACE-2 Tenecteplase Noninferior to Alteplase for Ischemic Stroke: TRACE-2
988192Medscape Medical News
Source: Medscape Cardiology Headlines - February 13, 2023 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Dual Antiplatelet Therapy Proves Mettle in Minor Stroke
(MedPage Today) -- DALLAS -- Dual antiplatelet therapy (DAPT) proved non-inferior to IV alteplase in Chinese patients with minor non-disabling stroke, a researcher reported. In the ARAMIS trial of patients with acute minor stroke who presented...
Source: MedPage Today Cardiovascular - February 13, 2023 Category: Cardiology Source Type: news

Tenecteplase on Par With Alteplase, Randomized Trial Affirms
(MedPage Today) -- DALLAS -- Tenecteplase (TNKase) did as good a job at ischemic stroke thrombolysis as did alteplase (Activase) for patients presenting within 4.5 hours of symptom onset in the randomized TRACE-2 trial from China. The proportion...
Source: MedPage Today Cardiovascular - February 9, 2023 Category: Cardiology Source Type: news