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Drug: Activase

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Total 1186 results found since Jan 2013.

Biosimilar tenecteplase versus alteplase in acute ischemic stroke: A real world study
Conclusion: This present study observed no difference in the efficacy and safety between biosimilar TNK and rTPA. Our findings are in concordance with published trials showing equivalence between the two molecules.
Source: Annals of Indian Academy of Neurology - January 25, 2023 Category: Neurology Authors: Ayush Mohan Snigdha Komakula Suhas Murali Pooja Anand Dyuti Shah VY Vishnu Awadh Kishor Pandit Ayush Agarwal Deepti Vibha Mamta Bhushan Singh MV Padma Srivastava Rohit Bhatia Source Type: research

Conversion From Intravenous Alteplase to Tenecteplase for Treatment of Acute Ischemic Stroke Across a Large Community Hospital Health System
CONCLUSION AND RELEVANCE: Conversion from alteplase to tenecteplase can be safely and effectively achieved at a large community hospital health system with differing levels of stroke certification. There were also additional cost savings and practical advantages including workflow benefits.PMID:36688289 | DOI:10.1177/10600280221149409
Source: The Annals of Pharmacotherapy - January 23, 2023 Category: Drugs & Pharmacology Authors: Erika Dittmar Thomas Wolfel Lourdes Menendez Jessilyn Pozo Maygret Ramirez Starlie C Belnap Felipe De Los Rios La Rosa Source Type: research

Tenecteplase vs. alteplase for treatment of acute ischemic stroke: A systematic review and meta-analysis of randomized trials
DiscussionBased on available evidence from completed RCTs, tenecteplase has proven similar safety and efficacy to alteplase for treatment of AIS.
Source: Frontiers in Neurology - January 23, 2023 Category: Neurology Source Type: research

A study on endovascular treatment alone and bridging treatment for acute ischemic stroke
ConclusionsAlthough there was no difference in clinical efficacy and safety between the abovementioned two groups, treatment with IVT  + EVT could increase the risk of bleeding compared to EVT. Moreover, in the 6–8 h subgroup, the efficacy of EVT alone was better than that of IVT + EVT.
Source: European Journal of Medical Research - January 7, 2023 Category: Research Source Type: research

Safety outcomes of early initiation of antithrombotic agents within 24  h after intravenous alteplase at 0.6 mg/kg
We examined outcome of acute ischemic stroke (AIS) with administration of antithrombotics within 24  h after intravenous low-dose alteplase.
Source: Journal of the Neurological Sciences - January 6, 2023 Category: Neurology Authors: Tetsuya Chiba, Takeshi Yoshimoto, Shinichi Wada, Masayuki Shiozawa, Sohei Yoshimura, Shunsuke Kimura, Manabu Inoue, Kazunori Toyoda, Masafumi Ihara, Masatoshi Koga Source Type: research

Safety outcomes of early initiation of antithrombotic agents within 24  h after intravenous alteplase at 0.6 mg/kg
We examined outcome of acute ischemic stroke (AIS) with administration of antithrombotics within 24  h after intravenous low-dose alteplase.
Source: Journal of the Neurological Sciences - January 6, 2023 Category: Neurology Authors: Tetsuya Chiba, Takeshi Yoshimoto, Shinichi Wada, Masayuki Shiozawa, Sohei Yoshimura, Shunsuke Kimura, Manabu Inoue, Kazunori Toyoda, Masafumi Ihara, Masatoshi Koga Source Type: research

Rescue stenting after the failure of intravenous thrombolysis and bridging thrombolysis: an initial Vietnamese report
CONCLUSIONS: Rescue stenting appears to represent an additional therapeutic option in cases that fail to resolve with IV alteplase, which may improve clinical outcomes.PMID:36591828 | DOI:10.26355/eurrev_202212_30667
Source: European Review for Medical and Pharmacological Sciences - January 2, 2023 Category: Drugs & Pharmacology Authors: M-T Le C-C Tran G Nguyen-Luu M-T Ngo N-H Nguyen-Dao L Duong-Hoang M Mai-Van M-D Nguyen Source Type: research