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Specialty: Cardiology
Drug: Beta-Blockers

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Total 184 results found since Jan 2013.

Sudden cardiac death in transposition of the great arteries with a Mustard or Senning baffle: the myocardial ischemia hypothesis
Purpose of review: The literature on sudden death in transposition of the great arteries (D-TGA) with atrial switch surgery is reviewed and a pathophysiological mechanism is proposed. Recent findings: Over 80% of sudden deaths in patients with D-TGA and Mustard or Senning baffles occur during exercise. Factors most consistently associated with ventricular arrhythmias and sudden death include heart failure parameters and atrial arrhythmias. Atrial arrhythmias have been observed to trigger malignant ventricular arrhythmias. Exercise may promote 1 : 1 conduction, with inordinately high ventricular rates. Reconstructed in...
Source: Current Opinion in Cardiology - December 1, 2016 Category: Cardiology Tags: PEDIATRICS: Edited by Mitchell I. Cohen Source Type: research

Turkish registry for diagnosis and treatment of acute heart failure: TAKTIK study.
CONCLUSION: Compared to previous data collected around the world, AHF patients in Turkey were younger, had more frequently valvular heart disease as the underlying cause, and were more noncompliant with medical treatment, but overall mortality was lower. Drugs shown to reduce mortality, and which also form the basis of guideline-directed medical therapy, are still used inadequately. PMID: 28045409 [PubMed - in process]
Source: Turk Kardiyoloji Dernegi arsivi - November 30, 2016 Category: Cardiology Authors: Eren M, Zoghi M, Tuncer M, Çavuşoğlu Y, Demirbağ R, Şahin M, Serdar OA, Onrat E, Mutlu H, Dursunoğlu D, Yılmaz MB, Temizhan A, TAKTIK Investigators Tags: Turk Kardiyol Dern Ars Source Type: research

Ivabradine and metoprolol differentially affect cardiac glucose metabolism despite similar heart rate reduction in a mouse model of dyslipidemia
This study aimed at testing whether similar HRR with ivabradine vs. metoprolol differentially modulates cardiac energy substrate metabolism, a factor determinant for cardiac function, in a mouse model of dyslipidemia (hApoB+/+;LDLR–/–). Following a longitudinal study design, we used 3- and 6-mo-old mice, untreated or treated for 3 mo with ivabradine or metoprolol. Cardiac function was evaluated in vivo and ex vivo in working hearts perfused with 13C-labeled substrates to assess substrate fluxes through energy metabolic pathways. Compared with 3-mo-old, 6-mo-old dyslipidemic mice had similar cardiac hemodynamics...
Source: AJP: Heart and Circulatory Physiology - September 30, 2016 Category: Cardiology Authors: Vaillant, F., Lauzier, B., Ruiz, M., Shi, Y., Lachance, D., Rivard, M.-E., Bolduc, V., Thorin, E., Tardif, J.-C., Des Rosiers, C. Tags: Energetics and Metabolism Source Type: research

Impact of Chronic Nitrate Therapy in Patients With Ischemic Heart Failure
Conclusion: Long-term nitrates use in patients with ischemic HF was associated with higher occurrence of ischemic events, defined as fatal or nonfatal myocardial infarction or stroke. Our results, although from a retrospective analysis, do not support a role for chronic nitrate use in HF.
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 4, 2016 Category: Cardiology Authors: Moreira-Silva, S., Urbano, J., Nogueira-Silva, L., Bettencourt, P., Pimenta, J. Tags: Clinical Study Source Type: research

Gender Discrepancy in Diabetic Patients Hospitalized With Heart Failure: Does Age Matter?
Conclusions: In DHF, female gender is characterized by having a high prevalence of metabolic syndrome components. Also, females are more likely to have better Left ventricular ejection fraction but less likely to receive cardiovascular evidence based medications. There is no significant difference in the overall hospital mortality between both genders, however, in the younger age; males have a significantly higher mortality.
Source: Critical Pathways in Cardiology - August 2, 2016 Category: Cardiology Tags: Original Studies Source Type: research

Pulmonary Hypertension due to Radiofrequency Catheter Ablation (RFCA) for Atrial Fibrillation: The Lungs, the Atrium or the Ventricle?
Atrial fibrillation is the most common heart rhythm disorder affecting around 2.5 million people in United States. It is characterised by rapid and irregular beating of both the atria resulting in the similar ventricular response. It is associated with the risk of stroke and heart failure resulting in increased morbidity and mortality [1]. The treatment of atrial fibrillation involves rate control with ant-arrhythmic drugs like beta blockers, digoxin and amiodarone. Cardioversion is recommended in case of haemodynamic instability or after failure of pharmacological therapies.
Source: Heart, Lung and Circulation - July 15, 2016 Category: Cardiology Authors: Isha Verma, Hemantkumar Tripathi, Rutuja Rajanikant Sikachi, Abhinav Agrawal Tags: Review Source Type: research

Clinical presentation, management, and outcomes in the Indian Heart Rhythm Society-Atrial Fibrillation (IHRS-AF) registry
Conclusions In India, AF patients are younger and RHD is still the most frequent etiology. Almost two-third of the patients have persistent/permanent AF. At one-year follow-up, there is a significant mortality and morbidity in AF patients in India.
Source: Indian Heart Journal - July 10, 2016 Category: Cardiology Source Type: research

STEMI vs NSTEACS management trends in non-invasive hospital.
CONCLUSION: NSTEACS patients in western province of KSA present at an older age are mostly males and have higher prevalence of hypertension and hyperlipidemia compared with STEMI patients. It is therefore important to identify patients with high-risk profile and put implement measures to reduce these factors. PMID: 27543475 [PubMed - in process]
Source: Indian Heart J - June 30, 2016 Category: Cardiology Authors: Kinsara AJ, Alrahimi JS, Yusuf OB Tags: Indian Heart J Source Type: research

Selective Heart Rate Reduction With Ivabradine Increases Central Blood Pressure in Stable Coronary Artery Disease Clinical Trials
In conclusion, the decrease in HR with ivabradine was associated with an increase in central systolic pressure, which may have antagonized possible benefits of HR lowering in coronary artery disease patients. Clinical Trials—URL: http://www.clinicaltrials.gov. Unique identifier NCT01039389.
Source: Hypertension - May 10, 2016 Category: Cardiology Authors: Rimoldi, S. F., Messerli, F. H., Cerny, D., Gloekler, S., Traupe, T., Laurent, S., Seiler, C. Tags: Hemodynamics, Hypertension, Coronary Artery Disease Clinical Trials Source Type: research

Treatment of Hypertension in Coarctation of the Aorta
Opinion statement The treatment of hypertension in coarctation of the aorta (CoA) is ideally managed by early surgical or transcatheter repair to reduce the risk of irreversible aortopathy and refractory hypertension, in addition to other associated sequelae including premature coronary artery disease; stroke; aortic aneurysm, dissection, and rupture; infective endocarditis; and heart failure. The choice of surgical or transcatheter repair is dependent on individual patient considerations. Medical therapy for hypertension due to CoA parallels treatment of essential hypertension with beta blockers, angiotensin-con...
Source: Current Treatment Options in Cardiovascular Medicine - April 18, 2016 Category: Cardiology Source Type: research

Prevalence of atrial fibrillation in an urban population in India: the Nagpur pilot study
Conclusions The prevalence of AF was low compared with other regions of the world and stroke prophylaxis was underused. A larger study is needed to confirm these findings. This study demonstrates that larger evaluations would be feasible using the community-based techniques employed here.
Source: Heart Asia - April 17, 2016 Category: Cardiology Authors: Saggu, D. K., Sundar, G., Nair, S. G., Bhargava, V. C., Lalukota, K., Chennapragada, S., Narasimhan, C., Chugh, S. S. Tags: Original research Source Type: research

Beta-blockers are not associated with stroke severity and outcome in hypertensive patients: data from a national stroke registry
Lowering blood pressure (BP) with beta-blockers is less effective in reducing the risk of stroke than with other agents. However, studies on associations between use of beta-blockers and stroke severity are inconclusive. We assessed the association between pre-stroke use of beta-blockers and stroke severity, disability and death in a large prospective national registry of hospitalized hypertensive patients with acute stroke.
Source: Journal of the American Society of Hypertension - March 31, 2016 Category: Cardiology Authors: Ehud Grossman, David Tanne, Silvia Koton Tags: Stroke Source Type: research

Secondary Prevention Beyond Hospital Discharge for ACS: Evidence-based Recommendations
Publication date: Available online 10 March 2016 Source:Canadian Journal of Cardiology Author(s): David H. Fitchett, Shaun G. Goodman, Lawrence A. Leiter, Peter Lin, Robert Welsh, James Stone, Jean Grégoire, Philip Mcfarlane, Anatoly Langer In the last three decades, a better understanding of the pathophysiology of cardiovascular disease has resulted in innovations in the treatment and prevention of its clinical manifestations such as death, myocardial infarction or stroke. Following an acute coronary syndrome there are short and long term risks of subsequent cardiovascular events. This leads to opportunities t...
Source: Canadian Journal of Cardiology - March 11, 2016 Category: Cardiology Source Type: research

Relationship between HRV measurements and demographic and clinical variables in a population of patients with atrial fibrillation
Abstract Little is known about the role of HRV in atrial fibrillation (AF) patients. Aim of our study was to assess the relationship between HRV measurements and demographic and clinical variables in a population of 274 AF patients. We selected all consecutive patients with persistent/permanent AF among whom had performed a Holter ECG in our Department from April 2010 to April 2015. Time-domain analysis of HRV was evaluated. Demographic and clinical variables were collected for each patient. At multivariable logistic regression, a higher pNN50 was associated with ACE inhibitors/ARBs (p = 0.016) and a lower pNN50...
Source: Heart and Vessels - March 3, 2016 Category: Cardiology Source Type: research

Abstract 12: Heart Failure Medications Prescribed at Discharge for Patients With Left Ventricular Assist Devices Session Title: Abstract Oral Session: Quality of Care
Conclusion: Traditional HF therapies are commonly prescribed to LVAD recipients, although less frequently than to advanced HF patients without LVAD support. Aldosterone antagonists are prescribed increasingly to LVAD patients. Further research is needed on the optimal medical regimen for patients with LVADs.
Source: Circulation: Cardiovascular Quality and Outcomes - February 26, 2016 Category: Cardiology Authors: Baras Shreibati, J., Sheng, S., Fonarow, G. C., DeVore, A. D., Yancy, C. W., Bhatt, D. L., Peterson, E. D., Hernandez, A., Heidenreich, P. A. Tags: Session Title: Abstract Oral Session: Quality of Care Source Type: research