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Specialty: Cardiology
Drug: Beta-Blockers

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Total 184 results found since Jan 2013.

A prospective survey in European Society of Cardiology member countries of atrial fibrillation management: baseline results of EURObservational Research Programme Atrial Fibrillation (EORP-AF) Pilot General Registry
Conclusion The EURObservational Research Programme Atrial Fibrillation (EORP-AF) Pilot Registry has provided systematic collection of contemporary data regarding the management and treatment of AF by cardiologists in ESC member countries. Oral anticoagulant use has increased, but novel OAC use was still low. Compliance with the treatment guidelines for patients with the lowest and higher stroke risk scores remains suboptimal.
Source: Europace - February 25, 2014 Category: Cardiology Authors: Lip, G. Y. H., Laroche, C., Dan, G.-A., Santini, M., Kalarus, Z., Rasmussen, L. H., Oliveira, M. M., Mairesse, G., Crijns, H. J. G. M., Simantirakis, E., Atar, D., Kirchhof, P., Vardas, P., Tavazzi, L., Maggioni, A. P. Tags: Atrial fibrillation Source Type: research

Heartbeat: Highlights from the issue
In this issue of Heart, Dr. Bouri and colleagues (see page 456) reexamined the issue of the perioperative use of beta blockers in patients with an intermediate or high cardiovascular risk who are undergoing major non cardiac surgery. Unfortunately, the evidence base for current recommendations has been called into question because of allegations of research fraud in some of the main studies, which are excluded from this new meta-analysis of the relevant randomized controlled clinical trials. They found that although beta-blockers decreased the risk of non-fatal myocardial infarction, they increased the risk of stroke and h...
Source: Heart - February 19, 2014 Category: Cardiology Authors: Otto, C. M. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Epidemiology Heartbeat Source Type: research

Meta-analysis of secure randomised controlled trials of {beta}-blockade to prevent perioperative death in non-cardiac surgery
Conclusions Guideline bodies should retract their recommendations based on fictitious data without further delay. This should not be blocked by dispute over allocation of blame. The well-conducted trials indicate a statistically significant 27% increase in mortality from the initiation of perioperative β-blockade that guidelines currently recommend. Any remaining enthusiasts might best channel their energy into a further randomised trial which should be designed carefully and conducted honestly.
Source: Heart - February 19, 2014 Category: Cardiology Authors: Bouri, S., Shun-Shin, M. J., Cole, G. D., Mayet, J., Francis, D. P. Tags: Open access, Drugs: cardiovascular system, Echocardiography, Interventional cardiology, Acute coronary syndromes, Clinical diagnostic tests, Epidemiology Cardiac risk factors and prevention Source Type: research

Impact of Atrial Fibrillation on Exercise Capacity in Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study Original Articles
Conclusions— AF identifies an HFpEF cohort with more advanced disease and significantly reduced exercise capacity. These data suggest that evaluation of the impact of different rate or rhythm control strategies on exercise tolerance in patients with HFpEF and AF is warranted. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00763867.
Source: Circulation: Heart Failure - January 21, 2014 Category: Cardiology Authors: Zakeri, R., Borlaug, B. A., McNulty, S. E., Mohammed, S. F., Lewis, G. D., Semigran, M. J., Deswal, A., LeWinter, M., Hernandez, A. F., Braunwald, E., Redfield, M. M. Tags: Congestive, Exercise/exercise testing/rehabilitation, Arrhythmias, clinical electrophysiology, drugs Original Articles Source Type: research

Heart Failure With Preserved Ejection Fraction Comparison of Patients With and Without Angina Pectoris (From the Duke Databank for Cardiovascular Disease)
This study investigated the characteristics and outcomes of patients with heart failure with preserved ejection fraction (HFpEF) and angina pectoris (AP).BackgroundAP is a predictor of adverse events in patients with heart failure with reduced EF. The implications of AP in HFpEF are unknown.MethodsWe analyzed HFpEF patients (EF ≥50%) who underwent coronary angiography at Duke University Medical Center from 2000 through 2010 with and without AP in the previous 6 weeks. Time to first event was examined using Kaplan-Meier methods for the primary endpoint of death/myocardial infarction (MI)/revascularization/stroke (i.e....
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - January 20, 2014 Category: Cardiology Source Type: research

Diuretics: A Review and Update
In conclusion, diuretics are a diverse class of drugs that remain extremely important in the management of hypertension and hypervolemic states.
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 17, 2013 Category: Cardiology Authors: Roush, G. C., Kaur, R., Ernst, M. E. Tags: Cardiovascular Pharmacology Core Reviews Source Type: research

Heart Failure With Preserved Ejection Fraction: Comparison of Patients With and Without Angina Pectoris (From the Duke Databank for Cardiovascular Disease)
This study investigated the characteristics and outcomes of patients with heart failure with preserved ejection fraction (HFpEF) and angina pectoris (AP).Background: AP is a predictor of adverse events in patients with heart failure with reduced EF. The implications of AP in HFpEF are unknown.Methods: We analyzed HFpEF patients (EF ≥50%) who underwent coronary angiography at Duke University Medical Center from 2000 through 2010 with and without AP in the previous 6 weeks. Time to first event was examined using Kaplan-Meier methods for the primary endpoint of death/myocardial infarction (MI)/revascularization/stroke (...
Source: Journal of the American College of Cardiology - October 25, 2013 Category: Cardiology Authors: Robert J. Mentz, Samuel Broderick, Linda K. Shaw, Mona Fiuzat, Christopher M. O'Connor Tags: Heart Failure Source Type: research

Adherence to antihypertensive therapy prior to the first presentation of stroke in hypertensive adults: population-based study
Conclusion These data suggest that poor adherence to antihypertensive therapy substantially increases near- and long-term risk of stroke among hypertensive patients.
Source: European Heart Journal - October 7, 2013 Category: Cardiology Authors: Herttua, K., Tabak, A. G., Martikainen, P., Vahtera, J., Kivimaki, M. Tags: Hypertension Source Type: research

Outcomes of invasive treatment in very elderly Polish patients with non-ST-segment-elevation myocardial infarction from 2003-2009 (from the PL-ACS registry).
CONCLUSIONS: Elderly patients with NSTEMI benefit significantly from invasive strategies and modern pharmacotherapy recommended by treatment guidelines. Nevertheless, this approach is associated with an increased incidence of major bleeding. PMID: 23558809 [PubMed - in process]
Source: Cardiology Journal - May 24, 2013 Category: Cardiology Authors: Gierlotka M, Gąsior M, Tajstra M, Hawranek M, Osadnik T, Wilczek K, Kalarus Z, Lekston A, Zembala M, Poloński L Tags: Cardiol J Source Type: research

Abstract 328: Coronary Artery Disease Performance Measures And Statin Use Between Patients With Recent Percutaneous Coronary Intervention (PCI)and Patients With Recent Coronary Artery Bypass Grafting (CABG): An Analysis From The NCDR(R). Poster Session III
Conclusion: Although overall compliance with CAD PMs between patients undergoing recent CABG compared to recent PCI is similar, only about one-fourth of patients in both groups met between 75-100% of eligible CAD PMs. Furthermore, distinct gaps were noted for specific PMs in the recent CABG group. Our study highlight areas for future quality improvement initiatives aimed at improving compliance in PMs in patients who have undergone recent revascularization.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Bandeali, S. J., Gosch, K., Negi, S. I., Alam, M., Kayani, W. T., Wilson, J. M., Chan, P. S., Maddox, T. M., Virani, S. S. Tags: Poster Session III Source Type: research

Abstract 150: Resource Utilization Patterns and Outcomes Among Acute Coronary Syndrome Patients: Findings From a Multi-Payer Analysis Poster Session II
Conclusion: These findings suggest that many patients with ACS do not receive appropriate recommended antithrombotic prophylaxis, and opportunities exist to improve therapy. Increased use of software tools such as AQuA may support enhanced education efforts aimed at improving adherence to guidelines and quality of care.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Lang, K., Bozkaya, D., Patel, A. A., Macomson, B., Crivera, C., Owens, G., Mody, S. Tags: Poster Session II Source Type: research

Heart failure: What does ejection fraction have to do with it?
Abstract Heart failure (HF) occurs across the entire range of left ventricular (LV) ejection fractions (EF), not just reduced EF. Nearly half or more patients presenting with HF have a preserved EF>0.50 (HFpEF). Diastolic dysfunction is apparent in all patients with HF, regardless of EF. A preserved EF indicates that the end-diastolic volume is appropriate for the stroke volume, and a reduced EF indicates that the end-diastolic volume is enlarged relative to stroke volume (i.e. the LV is dilated). Most therapies proven to be effective in HF with a reduced EF (ACE-inhibitors, angiotensin receptor blockers, beta-...
Source: Journal of Cardiology - May 11, 2013 Category: Cardiology Authors: Iwano H, Little WC Tags: J Cardiol Source Type: research

Temporal changes in patient characteristics and prior pharmacotherapy in patients undergoing radiofrequency ablation of atrial fibrillation: a Danish nationwide cohort study
Conclusion During a 10-year period, RFA was increasingly performed in older patients with higher co-morbidity, and without prior trial of antiarrhythmic therapy. These findings may provide a framework to understand the outcomes of RFA.
Source: Europace - April 26, 2013 Category: Cardiology Authors: Karasoy, D., Gislason, G. H., Hansen, J., Olesen, J. B., Torp-Pedersen, C., Johannessen, A., Hansen, M. L. Tags: Ablation for atrial fibrillation Source Type: research

Resistant hypertension: a frequent and ominous finding among hypertensive patients with atherothrombosis
Conclusion The presence of resistant hypertension identifies a subgroup of patients with hypertension and atherothrombosis who are at heightened risk for adverse long-term outcomes.
Source: European Heart Journal - April 21, 2013 Category: Cardiology Authors: Kumbhani, D. J., Steg, P. G., Cannon, C. P., Eagle, K. A., Smith, S. C., Crowley, K., Goto, S., Ohman, E. M., Bakris, G. L., Perlstein, T. S., Kinlay, S., Bhatt, D. L., on Behalf of the REACH Registry Investigators Tags: Hypertension Source Type: research

Clinical characteristics and outcomes of atrial fibrillation and flutter at the Aga Khan University Hospital, Nairobi.
CONCLUSION: Hypertension and diabetes mellitus, not rheumatic valve disease were the more common co-morbidities. Stroke risk stratification and prevention needs to be emphasised and appropriately managed. PMID: 23612946 [PubMed - in process]
Source: Cardiovascular Journal of Africa - March 1, 2013 Category: Cardiology Authors: Shavadia J, Yonga G, Mwanzi S, Jinah A, Moriasi A, Otieno H Tags: Cardiovasc J Afr Source Type: research