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Condition: Atrial Fibrillation
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Total 257 results found since Jan 2013.

Screening for Atrial Fibrillation using a Mobile, Single-Lead Electrocardiogram in Canadian Primary Care Clinics
ConclusionPreviously undiagnosed AF is common in older individuals attending primary care clinics. The Kardia Mobile ECG device appears to be an effective screening tool for AF with high physician acceptability. More research on the feasibility of such novel technologies is warranted for future consideration of integration in population-based screening programs.
Source: Canadian Journal of Cardiology - April 6, 2019 Category: Cardiology Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Incidence and Causes of In-hospital Outcomes and 30-day Readmissions After Percutaneous Left Atrial Appendage Closure: A United States Nationwide Retrospective Cohort Study Using Claims Data
Percutaneous left atrial appendage closure (p-LAAC) emerged as an option for stroke prevention in atrial fibrillation (AF) patients ’ ineligible for long-term anticoagulation.Real-world data on its in-hospital and 30-day readmission measures are limited.
Source: Heart Rhythm - September 16, 2019 Category: Cardiology Authors: Venkat L.K. Vuddanda, Mohit K. Turagam, Nikita A. Umale, Zubair Shah, Dhanunjaya R. Lakkireddy, Krzysztof Bartus, Finnian R. McCausland, Poonam Velagapudi, Moussa Mansour, E. Kevin Heist Source Type: research

Assessing patient preferences for switching from warfarin to direct oral anticoagulants
This study assessed patient preference for warfarin or DOAC based on a willingness to pay more for potential DOAC benefits. Current warfarin patients with atrial fibrillation or venous thromboembolism enrolled in the University of Utah Health Thrombosis Service were given a one-time electronic survey that assessed preferences between warfarin and DOACs using scenarios comparing effectiveness, safety, and convenience. When DOACs were preferred, patients were asked how much more they would be willing to pay monthly for the perceived advantages associated with DOACs. With 123 completed surveys, 68% of patients preferred to st...
Source: Journal of Thrombosis and Thrombolysis - October 19, 2019 Category: Hematology Source Type: research

Global research productions pertaining to atrial fibrillation from 2004 to 2018: A bibliometric analysis
Conclusion: Bibliometric analysis of the literature shows that research on AF continues to be a hot spot, and the clinical treatment of AF is an important research frontier. However, further research and collaboration are needed worldwide. Our findings aim to provide valuable information for the editors of journals that publish research on arrhythmia, and to help researchers identify new perspectives for future researches.
Source: Medicine - January 1, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Mobile-ECG screening in rural pharmacies: Rates of atrial fibrillation and associated risk factors
Atrial fibrillation (AFib) marks a significant health care burden with more than 46.3 million patients worldwide, and more than 6.1 million United States (US) adults experiencing at least one episode of AFib.3 The risk of stroke is significantly elevated in AFib patients and may not provide symptomatic cues of its occurrence.1 The importance and impact of AFib prompt the need for efficient identification and treatment of AFib across community settings.
Source: Heart and Lung - January 31, 2020 Category: Intensive Care Authors: Caley M. Kropp, Nichelle L. Huber, David Sager, Connor Tripp, Ashley Burch, Aditi Naniwadekar, Rajasekhar Nekkanti, Murrium I. Sadaf, J. Paul Mounsey, Samuel F. Sears Source Type: research

Remaining Challenges With Transcatheter Left Atrial Appendage Closure
Left atrial appendage closure has emerged as a feasible stroke prevention strategy in selected patients with nonvalvular atrial fibrillation. Since its commercial approval in the United States in 2015, the use of percutaneous left atrial appendage closure has witnessed a substantial growth. However, certain issues remain unresolved with the technology. Knowledge of these issues, their significance, and the current and future efforts to resolve them is key for proper informed decision making by physicians and patients.
Source: Mayo Clinic Proceedings - September 30, 2020 Category: Internal Medicine Authors: Mohamad Alkhouli, David R. Holmes Tags: Concise review for clinicians Source Type: research

Contemporary Procedural Trends of Watchman Percutaneous Left Atrial Appendage Occlusion in the United States
ConclusionIn contemporary United States clinical practice, Watchman utilization has increased significantly since approval in 2015, while complications and in ‐patient mortality have declined.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - November 5, 2020 Category: Cardiology Authors: Muhammad Bilal Munir, Muhammad Zia Khan, Douglas Darden, Deepak Kumar Pasupula, Sudarshan Balla, Frederick T. Han, Ryan Reeves, Jonathan C. Hsu Tags: ORIGINAL ARTICLES Source Type: research

Benefit-Risk Tradeoffs in Assessment of New Drugs and Devices.
Abstract Balancing benefits and risks is a complex task that poses a major challenge, both to the approval of new medicines and devices by regulatory authorities and in therapeutic decision-making in practice. Several analysis methods and visualization tools have been developed to help evaluate and communicate whether the benefit-risk profile is favorable or unfavorable. In this White Paper, we describe approaches to benefit-risk assessment using qualitative approaches such as the Benefit Risk Action Team framework developed by the Pharmaceutical Research and Manufacturers of America, and the Benefit-Risk Framewor...
Source: Circulation - November 17, 2020 Category: Cardiology Authors: Kaul S, Stockbridge N, Butler J Tags: Circulation Source Type: research

Contemporary procedural trends of Watchman percutaneous left atrial appendage occlusion in the United States
ConclusionIn contemporary United States clinical practice, Watchman utilization has increased significantly since approval in 2015, while complications and in ‐patient mortality have declined.
Source: Journal of Cardiovascular Electrophysiology - November 11, 2020 Category: Cardiology Authors: Muhammad Bilal Munir, Muhammad Zia Khan, Douglas Darden, Deepak K. Pasupula, Sudarshan Balla, Frederick T. Han, Ryan Reeves, Jonathan C. Hsu Tags: ORIGINAL ARTICLES Source Type: research

Primary Outcome Evaluation of a Next Generation Left Atrial Appendage Closure Device: Results from the PINNACLE FLX Trial
Conclusions: LAA closure with this next generation LAA closure device was associated with a low incidence of adverse events and a high incidence of anatomic closure. Clinical Trial Registration: URL https://clinicaltrials.gov Unique Identifier NCT02702271.PMID:33820423 | DOI:10.1161/CIRCULATIONAHA.120.050117
Source: Circulation - April 6, 2021 Category: Cardiology Authors: Saibal Kar Shephal K Doshi Ashish Sadhu Rodney Horton Jose Osorio Christopher Ellis James Stone Manish Shah Srinivas R Dukkipati Stuart Adler Devi G Nair Jamie Kim Oussama Wazni Matthew J Price Federico M Asch David R Holmes Robert D Shipley Nicole T Gord Source Type: research

Antidiabetic drugs for preventing atrial fibrillation: A new revolution?
Type 2 diabetes mellitus (DM) and atrial fibrillation (AF) are 2 of the great epidemics of our time. DM affects an estimated 8.5% of adults in the United States1 and is associated with an increased risk of cardiovascular events, including AF.2 AF in turn affects up to an estimated 12.5% of adults older than 65 years in the United States, decreases quality of life, and increases the risks of heart failure, stroke, and death.3,4 In 2015, the EMPA-REG OUTCOME (BI 10773 [Empagliflozin] Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) randomized controlled trial (RCT), which assessed the sodium glucose c...
Source: Heart Rhythm - April 7, 2021 Category: Cardiology Authors: William F. McIntyre, Jeff S. Healey Tags: Editorial Commentary Source Type: research

Single-Dose del Nido Cardioplegia Compared With Standard Cardioplegia During Coronary Artery Bypass Grafting at a Veterans Affairs Hospital
Tex Heart Inst J. 2021 Jan 1;48(1):e196981. doi: 10.14503/THIJ-19-6981.ABSTRACTDel Nido cardioplegic solution (DNC), used chiefly in pediatric patients, rapidly induces prolonged cardiac arrest during cardiac surgery. To determine whether surgical outcomes after coronary artery bypass grafting in a United States military veteran population differed when DNC was used instead of our standard Plegisol cardioplegia, we retrospectively reviewed 155 consecutive operations performed from July 2016 through June 2017. Del Nido cardioplegia was used to induce cardiac arrest in 70 patients, and Plegisol in 85. Compared with the Plegi...
Source: Texas Heart Institute Journal - May 4, 2021 Category: Cardiology Authors: Michael R Reidy Ernesto Jimenez Shuab Omer Lorraine D Cornwell Sabrina X Runbeck Ourania Preventza Gabriel Loor Todd K Rosengart Joseph S Coselli Source Type: research