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Total 71 results found since Jan 2013.
Stroke Prevention with Hydroxyurea Enabled through Research and Education (SPHERE): a Phase 2 primary stroke prevention trial in sub-Saharan Africa
CONCLUSION: SPHERE has built local capacity with high-quality research infrastructure and TCD screening for SCA in Tanzania. Fully enrolled, participants have a high prevalence of elevated baseline TCD velocities and splenomegaly. SPHERE will prospectively determine the benefits of hydroxyurea at MTD for primary stroke prevention, anticipating expanded access to hydroxyurea treatment across Tanzania.PMID:35977532 | DOI:10.1159/000526322
Source: Acta Haematologica - August 17, 2022 Category: Hematology Authors: Luke R Smart Emmanuela E Ambrose Georgina Balyorugulu Primrose Songoro Idd Shabani Protas Komba Mwesige Charles Thad A Howard Kathryn E McElhinney Sara M O'Hara Jodie Odame Maria Nakafeero Janet Adams Susan E Stuber Adam Lane Teresa S Latham Abel N Makubi Source Type: research
Apolipoprotein E genotypes in stroke patients from urban Tanzania
Stroke disproportionately affects low- and middle-income countries (LMICs) with an increasing burden in Sub-Saharan African populations, who are undergoing an epidemiological transition. The ε2 and ε4 gene variants of apolipoprotein E (ApoE) are each linked to an increased risk of intracerebral hemorrhage [1], although the mechanisms of this association are not well understood. There also appear to be connections between ischemic stroke and ApoE gene variants, especially ε4, although these are less established [2].
Source: Journal of the Neurological Sciences - June 25, 2022 Category: Neurology Authors: Dylan R. Rice, Andre C. Vogel, Seif S. Ismail, Kigocha Okeng'o, Grace K. Lugemwa, Jonathan Henry, Christina Kourkoulis, Farrah J. Mateen Source Type: research
MEASURING AMBULATION, MOTOR, AND BEHAVIORAL OUTCOMES WITH POST-STROKE FLUOXETINE IN TANZANIA: THE Phase II MAMBO TRIAL
We test the safety of fluoxetine post-ischemic stroke in Sub-Saharan Africa. Adults with acute ischemic stroke, seen
Source: Journal of Stroke and Cerebrovascular Diseases - March 20, 2022 Category: Neurology Authors: Emmanuel Massawe, Notburga A. Mworia, Seif Ismail, Dylan R. Rice, Andre C. Vogel, Boniface Kapina, Novath Mukyanuzi, Deus C. Buma, Jef Gluckstein, Michael Wasserman, Susan E. Fasoli, Faraja Chiwanga, Farrah J. Mateen, Kigocha Okeng'o Source Type: research
Effect of age, cerebral infarcts, vasculopathy and haemoglobin on cognitive function, in Tanzanian children with sickle cell anaemia
CONCLUSION: In this Tanzanian study, cognitive performance was reduced in children with SCA with or without SCI on MRI or vasculopathy. Cognitive performance improved with increasing age. Lower Hb was associated with lower cognitive performance in both patients with SCA and their non-SCA siblings. SCI and vasculopathy do not appear to have an impact on cognitive function.PMID:35182942 | DOI:10.1016/j.ejpn.2022.01.010
Source: European Journal of Paediatric Neurology - February 19, 2022 Category: Neurology Authors: Mboka Jacob Hanne Stotesbury Edward Kija Dawn Saunders Rachel J Mtei Hilda Tutuba Upendo Masanu Mrema Kilonzo Ramadhan Kazema Anna M Hood Fenella Kirkham Dagmara Dimitriou Julie Makani Source Type: research
Measuring Ambulation, Motor, and Behavioral Outcomes with Poststroke Fluoxetine in Tanzania: The Phase II MAMBO Trial
Am J Trop Med Hyg. 2021 Dec 6:tpmd210653. doi: 10.4269/ajtmh.21-0653. Online ahead of print.ABSTRACTWe test the safety of fluoxetine postischemic stroke in sub-Saharan Africa. Adults with acute ischemic stroke, seen <14 days since new-onset motor deficits, were enrolled from November 2019 to October 2020 in a single-arm, open-label phase II trial of daily fluoxetine 20 mg for 90 days at Muhimbili National Hospital, Dar es Salaam, Tanzania. The primary outcome was safety with secondary outcomes of medication adherence and tolerability. About 34 patients were enrolled (11 were female; mean age 52.2 years, 65% < 60 year...
Source: Am J Trop Med Hyg - December 6, 2021 Category: Infectious Diseases Authors: Farrah Mateen Emmanuel Massawe Notburga Mworia Seif Ismail Dylan Rice Andre Vogel Boniface Kapina Novath Mukyanuzi Deus Buma Jef Gluckstein Michael Wasserman Susan Fasoli Faraja Chiwanga Kigocha Okeng'o Source Type: research
