Apolipoprotein E genotypes in stroke patients from urban Tanzania

Stroke disproportionately affects low- and middle-income countries (LMICs) with an increasing burden in Sub-Saharan African populations, who are undergoing an epidemiological transition. The ε2 and ε4 gene variants of apolipoprotein E (ApoE) are each linked to an increased risk of intracerebral hemorrhage [1], although the mechanisms of this association are not well understood. There also appear to be connections between ischemic stroke and ApoE gene variants, especially ε4, although these are less established [2].

Source: Journal of the Neurological Sciences - June 25, 2022 Category: Neurology Authors: Dylan R. Rice, Andre C. Vogel, Seif S. Ismail, Kigocha Okeng'o, Grace K. Lugemwa, Jonathan Henry, Christina Kourkoulis, Farrah J. Mateen Source Type: research