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Total 106 results found since Jan 2013.

Acroangiodermatitis presenting as unilateral hypertrophic verrucous plaques
Dermatol Online J. 2022 Mar 15;28(2). doi: 10.5070/D328257400.ABSTRACTAcroangiodermatitis (AAD)[KL1] is a rare vasoproliferative disorder often involving the extremities that has been classified into two variants. Mali-type AAD is more common and associated with chronic venous stasis. Stewart-Bluefarb syndrome[KL2], the other variant, is associated with underlying arteriovenous abnormalities. Mali-type AAD is a relatively benign diagnosis but it may mimic more harmful etiologies such as Kaposi sarcoma both clinically and histologically. A 67-year-old woman with a history of varicose veins, deep vein thrombosis, stroke, and...
Source: Dermatol Online J - June 7, 2022 Category: Dermatology Authors: Kyle Lauck Quoc-Bao Nguyen Natasha Klimas Megan Rogge Source Type: research

Mechanisms of calcification in Fahr disease and exposure of potential therapeutic targets
Purpose of review There is growing interest in disorders involved in ectopic mineralization. Fahr disease or idiopathic basal ganglia calcification can serve as a model for ectopic mineralization in the basal ganglia, which is fairly common in the general population. In this review, we will focus on causative gene mutations and corresponding pathophysiologic pathways in Fahr disease. Recent findings Patients with Fahr disease have a variability of symptoms, such as movement disorders, psychiatric signs, and cognitive impairment, but can also be asymptomatic. Fahr disease is mostly autosomal dominant inherited, and there a...
Source: Neurology Clinical Practice - October 12, 2020 Category: Neurology Authors: Peters, M. E. M., de Brouwer, E. J. M., Bartstra, J. W., Mali, W. P. T. M., Koek, H. L., Rozemuller, A. J. M., Baas, A. F., de Jong, P. A. Tags: CT, Other cerebrovascular disease/ Stroke, Gene expression studies, Basal ganglia Review Source Type: research

Combination of Dexmedetomidine and Ketamine for Magnetic Resonance Imaging Sedation
Conclusions: The efficacy of DEX–KET sedation was comparable to that of midazolam for MRI examination. DEX–KET was related to shorter scan time and lower occurrence of complications compared to midazolam. Introduction Neurocritically ill patients often require brain magnetic resonance imaging (MRI) in addition to conventional neurological evaluations. Brain MRI can reveal structural lesions with a high sensitivity due to its excellent spatial resolution and enhanced soft tissue contrast (1–3). To acquire MRI images, patients' cooperation is imperative. However, keeping patients with ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Influence of Stent Design and Use of Protection Devices on Outcome of Carotid Artery Atenting: A Pooled Analysis of Individual Patient Data
Pooled data of 1557 patients treated with stents in three randomized controlled trials (RCTs; EVA-3S, SPACE, ICSS) comparing carotid artery stenting (CAS) vs carotid endarterectomy (CEA) for symptomatic disease.
Source: Journal of Vascular Surgery - August 22, 2018 Category: Surgery Authors: F. Wodarg, E.L. Turner, J. Dobson, P.A. Ringleb, W.P. Mali, G. Fraedrich Tags: Closed-cell stents are associated with lower risk of stroke or death with carotid artery stenting but filter-type protection devices are not Source Type: research

Risk factors for atherosclerotic and medial arterial calcification of the intracranial internal carotid artery
Calcifications of the intracranial internal carotid artery (iICA) are an important risk factor for stroke. The calcifications can occur both in the intimal and medial layer of the vascular wall. The aim of this study is to assess whether medial calcification in the iICA is differently related to risk factors for cardiovascular disease, compared to intimal calcification.
Source: Atherosclerosis - July 7, 2018 Category: Cardiology Authors: Annelotte Vos, Remko Kockelkoren, Jill B. de Vis, Yvonne T. van der Schouw, Irene C. van der Schaaf, Birgitta K. Velthuis, Willem P.T.M. Mali, Pim A. de Jong, the DUST study group Source Type: research

Degree of anemia, indirect markers of hemolysis, and vascular complications of sickle cell disease in Africa
In conclusion, severe anemia at steady state in SCD patients living in West and Central Africa is associated with elevated TRV, microalbuminuria, and leg ulcers, but these vascular complications are not independently associated with indirect markers of increased hemolysis. Other mechanisms leading to anemia, including malnutrition and infectious diseases, may also play a role in the development of SCD vasculopathy.
Source: Blood - November 16, 2017 Category: Hematology Authors: Dubert, M., Elion, J., Tolo, A., Diallo, D. A., Diop, S., Diagne, I., Sanogo, I., Belinga, S., Guifo, O., Wamba, G., Ngo Sack, F., Boidy, K., Kamara, I., Traore, Y., Diakite, C. O., Gbonon, V., Faye, B. F., Seck, M., Deme Ly, I., Chelo, D., NGuetta, R., D Tags: Sickle Cell Disease, Red Cells, Iron, and Erythropoiesis Source Type: research

The prevalence and distribution of intracranial carotid artery calcification in the young and middle-aged
We examined the prevalence and volume of ICAC in a large sample of young and middle aged individuals.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Daniel Bos, Remko Kockelkoren, Willem Aussems, Meike Vernooij, Willem Mali, Pim de Jong, Aad van der Lugt Source Type: research

Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.
CONCLUSIONS: Thus, smooth muscle STIM1 plays a crucial role in the development of hypertension and associated cardiovascular pathologies and represents a promising target for cardiovascular therapy. PMID: 27470514 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 27, 2016 Category: Cardiology Authors: Kassan M, Ait-Aissa K, Radwan E, Mali V, Haddox S, Gabani M, Zhang W, Belmadani S, Irani K, Trebak M, Matrougui K Tags: Arterioscler Thromb Vasc Biol Source Type: research

Homocysteine and progression of generalized small-vessel disease: The SMART-MR Study
Conclusions: Our findings implicate a role for homocysteine in the development of a generalized small-vessel disease in which both brain and kidney are affected.
Source: Neurology - March 3, 2014 Category: Neurology Authors: Kloppenborg, R. P., Geerlings, M. I., Visseren, F. L., Mali, W. P. T. M., Vermeulen, M., van der Graaf, Y., Nederkoorn, P. J., On behalf of the SMART Study Group Tags: MRI, Other cerebrovascular disease/ Stroke, Clinical trials Observational study (Cohort, Case control), Cohort studies ARTICLE Source Type: research

Carotid Stenting: Is There an Operator Effect? A Pooled Analysis From the Carotid Stenting Trialists' Collaboration Clinical Sciences
Conclusions— Carotid stenting should only be performed by operators with annual procedure volume ≥6 cases per year.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Calvet, D., Mas, J.-L., Algra, A., Becquemin, J.-P., Bonati, L. H., Dobson, J., Fraedrich, G., Jansen, O., Mali, W. P., Ringleb, P. A., Chatellier, G., Brown, M. M., Carotid Stenting Trialists' Collaboration (CSTC)--Writing Committee:, Calvet, Mas, Algra, Tags: Secondary prevention, Angioplasty and Stenting Clinical Sciences Source Type: research

Predictors of Acute and Persisting Ischemic Brain Lesions in Patients Randomized to Carotid Stenting or Endarterectomy Brief Reports
Conclusions— Stenting caused more acute and persisting ischemic brain lesions than endarterectomy. However, the rate of conversion from acute to persisting lesions was lower in the stenting group, most likely attributable to lower acute lesion volumes. Clinical Trial Registration —URL: www.isrctn.org. Unique identifier: ISRCTN25337470.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Rostamzadeh, A., Zumbrunn, T., Jongen, L. M., Nederkoorn, P. J., Macdonald, S., Lyrer, P. A., Kappelle, L. J., Mali, W. P. T. M., Brown, M. M., van der Worp, H. B., Engelter, S. T., Bonati, L. H., on behalf of the ICSS-MRI Substudy Investigators, The foll Tags: Carotid Stenosis, Computerized tomography and Magnetic Resonance Imaging, Carotid endarterectomy, Angioplasty and Stenting Brief Reports Source Type: research

Effects of carotid endarterectomy or stenting on hemodynamic complications in the International Carotid Stenting Study: a randomized comparison
ConclusionHemodynamic depression occurs more often after carotid artery stenting and severe hypertension more often after carotid endarterectomy, but these complications are not responsible for the excess of major perioperative events after carotid artery stenting.
Source: International Journal of Stroke - July 9, 2013 Category: Neurology Authors: Aysun Altinbas, Ale Algra, Martin M. Brown, Roland L. Featherstone, L. Jaap Kappelle, Gert Jan Borst, Willem P. Th. M. Mali, H. Bart der Worp, Tags: Research Source Type: research

Development and validation of a prediction rule for recurrent vascular events based on a cohort study of patients with arterial disease: the SMART risk score
Conclusions Patients at high risk for recurrent vascular events can be identified based on readily available clinical characteristics.
Source: Heart - May 13, 2013 Category: Cardiology Authors: Dorresteijn, J. A. N., Visseren, F. L. J., Wassink, A. M. J., Gondrie, M. J. A., Steyerberg, E. W., Ridker, P. M., Cook, N. R., van der Graaf, Y., on behalf of the SMART Study Group, Algra, Grobbee, Rutten, Moll, Kappelle, Mali, Doevendans Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Clinical diagnostic tests, Epidemiology, Tobacco use Prognosis research Source Type: research