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Total 1731 results found since Jan 2013.

Perceived Level of Life Enjoyment and Risk of Developing Disabling Dementia: The Japan Public Health Center-Based Study
DISCUSSION: A higher level of life enjoyment was associated with a lower risk of disabling dementia, particularly in the low-medium mental stress group. This finding suggests the importance of having life enjoyment by managing mental stress for reducing risk of disabling dementia.PMID:37718836 | DOI:10.1093/geronb/gbad129
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Tomokazu Tajima Ai Ikeda Takeshi Tanigawa Hiroyasu Iso Kazumasa Yamagishi Takumi Matsumura Nobufumi Yasuda Manami Inoue Shoichiro Tsugane Norie Sawada Japan Public Health Center –Based Study Group Source Type: research

Soluble C-type lectin-like receptor 2 in stroke (CLECSTRO) study: protocol of a multicentre, prospective cohort of a novel platelet activation marker in acute ischaemic stroke and transient ischaemic attack
This study was approved by the Ethical Committee of the University of Yamanashi as the central ethical committee in agreement with the ethical committees of all collaborative stroke centres. Informed consent will be obtained by an opt-out form from the patients at each stroke centre according to the Ethical Guidelines for Medical and Biological Research Involving Human Subjects by the Japanese Ministry of Health, Labour and Welfare. Trial registration numbers NCT05579405, UMIN000048954
Source: BMJ Open - September 18, 2023 Category: General Medicine Authors: Uchiyama, S., Suzuki-Inoue, K., Wada, H., Okada, Y., Hirano, T., Nagao, T., Kinouchi, H., Itabashi, R., Hoshino, H., Oki, K., Honma, Y., Ito, N., Sugimori, H., Kawamura, M. Tags: Open access, Diagnostics Source Type: research

Characteristics and outcomes of unknown onset stroke: The Japan Stroke Data Bank
This study aimed to investigate and describe the characteristics and clinical outcomes of patients with UOS.
Source: Journal of the Neurological Sciences - September 13, 2023 Category: Neurology Authors: Shinichi Wada, Sohei Yoshimura, Kazunori Toyoda, Michikazu Nakai, Yusuke Sasahara, Kaori Miwa, Junpei Koge, Akiko Ishigami, Masayuki Shiozawa, Kuniaki Ogasawara, Takanari Kitazono, Shigeru Nogawa, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Kazuo Minematsu, Ma Source Type: research

Roche and Alnylam report positive topline results from Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi therapeutic in development to treat hypertension in patients at high risk of cardiovascular disease
Zilebesiran met primary endpoint demonstrating greater than 15 mmHg reduction of systolic blood pressure at three months of treatment compared to placeboStudy met key secondary endpoints showing consistent and sustained reductions of systolic blood pressure at six monthsZilebesiran demonstrated an encouraging safety and tolerability profile in adult patients with mild-to-moderate hypertensionFull study results to be presented at an upcoming scientific conferenceBasel, 7 September 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Alnylam announced today that the Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi the...
Source: Roche Media News - September 7, 2023 Category: Pharmaceuticals Source Type: news

Access to mechanical thrombectomy and ischemic stroke mortality in Japan: a spatial ecological study
ConclusionAccess to mechanical thrombectomy was estimated, and regional differences were observed. The relationship between accessibility and IS mortality is unknown; however, regardless of accessibility, municipalities with a high proportion of workers in secondary industries and a small proportion with bachelor’s degrees or above are at risk of death from stroke.
Source: Frontiers in Neurology - September 5, 2023 Category: Neurology Source Type: research

Endovascular therapy for acute intracranial large vessel occlusion due to atherothrombosis: Multicenter historical registry
CONCLUSIONS: The incidence of recurrent ischemic stroke or reocclusion after EVT for AT-LVO was higher in the intracranial group.PMID:37648433 | DOI:10.1136/jnis-2023-020670
Source: Atherosclerosis - August 30, 2023 Category: Cardiology Authors: Kazutaka Uchida Hiroshi Yamagami Nobuyuki Sakai Manabu Shirakawa Mikiya Beppu Kazunori Toyoda Yuji Matsumaru Yasushi Matsumoto Kenichi Todo Mikito Hayakawa Seigo Shindo Shinzo Ota Masafumi Morimoto Masataka Takeuchi Hirotoshi Imamura Hiroyuki Ikeda Kanta Source Type: research

Improve Your Memory A Whopping 27%
Traditional doctors think the best way to treat memory loss is with Big Pharma’s latest “breakthrough” drug. And when it’s proven not to work – not to mention dangerous – they simply pull another one out of their pocket… That’s why I’m so concerned about the media buzz surrounding Lecanemab, one of the latest FDA-approved Alzheimer’s drug. Because I want to be clear: It is NOT a wonder drug. Lecanemab is a pharmaceutical product that, in clinical trials, resulted in a slight decline in cases of early Alzheimer’s when compared to a placebo. But…it was also associated with a long list of extremel...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Source Type: news

Impact of areal socioeconomic status on prehospital delay of acute ischaemic stroke: retrospective cohort study from a prefecture-wide survey in Japan
Conclusions Living in socioeconomically disadvantaged municipalities was associated with prehospital delays of acute ischaemic stroke in non-capital areas in Kochi prefecture, Japan. Poorer outcomes of those patients may be caused by delayed treatment of intravenous rt-PA and endovascular reperfusion therapy. Further studies are necessary to determine social risk factors in the capital areas. Trial registration number This article is linked to a clinical trial to UMIN000050189, No.: R000057166 and relates to its Result stage.
Source: BMJ Open - August 24, 2023 Category: General Medicine Authors: Fukuda, H., Hyohdoh, Y., Ninomiya, H., Ueba, Y., Ohta, T., Kawanishi, Y., Kadota, T., Hamada, F., Fukui, N., Nonaka, M., Kawada, K., Fukuda, M., Nishimoto, Y., Matsushita, N., Nojima, Y., Kida, N., Hayashi, S., Izumidani, T., Nishimura, H., Moriki, A., Ue Tags: Open access, Neurology Source Type: research

Epidemiology of cardiovascular disease in Japan: An overview study
J Cardiol. 2023 Aug 15:S0914-5087(23)00200-9. doi: 10.1016/j.jjcc.2023.08.006. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs), such as heart disease and stroke, have a significant impact on life expectancy, healthy life expectancy, and medical costs in Japan. Each prefecture is currently promoting measures in accordance with the Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease, which was established by the government. In recent years, the crude mortality rate of heart disease in Japan has been increasing year by year with the aging population. Meanwhile, the ...
Source: Journal of Cardiology - August 17, 2023 Category: Cardiology Authors: Tetsuya Ohira Eri Eguchi Fumikazu Hayashi Minako Kinuta Hironori Imano Source Type: research

Genes That Extend Lifespan May Do So by Mitigating the Increased Risk of Death Posed by Having Hypertension
Am J Hypertens. 2023 Aug 10:hpad070. doi: 10.1093/ajh/hpad070. Online ahead of print.ABSTRACTGenetic factors influence lifespan. In humans, there appears to be a particularly strong genetic effect in those aged ≥ 90 years. An important contribution is nutrient sensing genes which confer cell resilience. Our research has been investigating the genetic factors by longitudinal studies of American men of Japanese descent living on the island of Oahu in Hawaii. This cohort began as the Honolulu Heart Program in the mid-1960s and most subjects are now deceased. We previously discovered various genes containing polymorphisms as...
Source: American Journal of Hypertension - August 10, 2023 Category: Cardiology Authors: Brian J Morris Timothy A Donlon Source Type: research

External Validation of the HELT-E < sub > 2 < /sub > S < sub > 2 < /sub > Score in Japanese Patients With Nonvalvular Atrial Fibrillation 　- A Pooled Analysis of the RAFFINE and SAKURA Registries
CONCLUSIONS: The HELT-E2S2score demonstrated potential value for risk stratification, particularly in a super-aged society such as Japan. However, its superiority over the CHADS2or CHA2DS2-VASc scores may vary across different hospital settings.PMID:37558457 | DOI:10.1253/circj.CJ-23-0318
Source: Circulation Journal - August 9, 2023 Category: Cardiology Authors: Takahiro Yamauchi Yasuo Okumura Koichi Nagashima Ryuta Watanabe Yuki Saito Katsuaki Yokoyama Naoya Matsumoto Katsumi Miyauchi Sakiko Miyazaki Hidemori Hayashi Yuya Matsue Yuji Nishizaki Shuko Nojiri Tohru Minamino Hiroyuki Daida Source Type: research