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Rural-urban and geographical differences in prognosis of atrial fibrillation in Finland: a nationwide cohort study
CONCLUSIONS: Rural-urban differences in prognosis of AF in Finland appear minimal, whereas considerable disparities exist between HDs.PMID:37571929 | DOI:10.1177/14034948231189918
Source: Scandinavian Journal of Public Health - August 12, 2023 Category: International Medicine & Public Health Authors: Konsta Teppo K E Juhani Airaksinen Olli Halminen Jussi Jaakkola Miika Linna Jari Haukka Jukka Putaala Pirjo Mustonen Janne Kinnunen Juha Hartikainen Mika Lehto Source Type: research

Outcome of transcatheter atrial septal defect closure in a nationwide cohort
CONCLUSION: After TC closure of ASD, patients had a higher risk of new-onset atrial fibrillation and migraine than controls without ASD. As novel findings, we found an increased risk for ischemic heart disease, AV conduction disorders, and ventricular fibrillation/tachycardia.Key messagesEven though patients have an excellent overall prognosis after percutaneous ASD closure, the increased incidence of major comorbidities like atrial fibrillation and heart failure prompts more thorough lifelong follow-up.This study's novel findings revealed the increased risk for ischemic heart disease, AV conduction disorders, or ventricul...
Source: Annals of Medicine - February 14, 2023 Category: Internal Medicine Authors: V Muroke M Jalanko J Haukka J Hartikainen A Tahvanainen H Ukkonen K Ylitalo J Pihkala J Sinisalo Source Type: research

Early statin use and cardiovascular outcomes after myocardial infarction: A population-based case-control study
CONCLUSIONS: Lack of statin therapy early after MI is associated with adverse outcomes across the spectrum of MI patients. Results underline the importance of timely statin use after MI.PMID:35803064 | DOI:10.1016/j.atherosclerosis.2022.06.1019
Source: Atherosclerosis - July 8, 2022 Category: Cardiology Authors: Ville Kyt ö Antti Saraste Aleksi Tornio Source Type: research

Income and outcomes of patients with incident atrial fibrillation
Conclusions Personal annual income has a significant impact on the incidence of first-ever ischaemic stroke and overall mortality among patients with incident AF, particularly among patients of working age. Low-income indicate the need for intervention strategies to improve outcomes of AF. Trial registration number NCT04645537.
Source: Journal of Epidemiology and Community Health - July 8, 2022 Category: Epidemiology Authors: Biancari, F., Teppo, K., Jaakkola, J., Halminen, O., Linna, M., Haukka, J., Putaala, J., Mustonen, P., Kinnunen, J., Hartikainen, J., Aro, A., Airaksinen, J., Lehto, M. Tags: Open access Original research Source Type: research

Association of income and educational levels with adherence to direct oral anticoagulant therapy in patients with incident atrial fibrillation: A Finnish nationwide cohort study
In conclusion, we observed that income and ed ucational levels both have independent positive association on the implementation of DOAC therapy but no association on therapy persistence in patients with AF.
Source: Pharmacology Research and Perspectives - May 23, 2022 Category: Drugs & Pharmacology Authors: Konsta Teppo, Jussi Jaakkola, Fausto Biancari, Olli Halminen, Miika Linna, Jari Haukka, Jukka Putaala, Paula Tiili, Ossi Lehtonen, Mikko Niemi, Pirjo Mustonen, Janne Kinnunen, Juha Hartikainen, K. E. Juhani Airaksinen, Mika Lehto Tags: ORIGINAL ARTICLE Source Type: research

The nationwide Finnish anticoagulation in atrial fibrillation (FinACAF): study rationale, design, and patient characteristics
AbstractAtrial fibrillation (AF) is a major cause of ischemic stroke and the number of AF patients is increasing. Thus, up-to-date multifaceted data about the characteristics of AF patients, their treatments, and outcomes are urgently needed. The Finnish anticoagulation in atrial fibrillation (FinACAF) study has collected comprehensive data on all Finnish AF patients from 1st January 2004 to 31st December 2018. The aim of this paper is to describe the study rationale, the process of integrating data from the applied resources and to define the study cohort. Using national unique personal identification number, individual p...
Source: European Journal of Epidemiology - January 5, 2022 Category: Epidemiology Source Type: research

Commentary: Postpericardial syndrome after cardiac surgery: Is it really benign?
Lehto and colleagues1 report on the long-term outcomes of postpericardiotomy syndrome (PPS) occurring after aortic valve replacement (AVR) surgery. The patient cohort was drawn from 2 large Finnish multi-institutional clinical trial databases, namely CAREAVR (Consortium of Studies in the Field of Atrial Fibrillation, Stroke, and Bleeding in Patients Undergoing Aortic Valve Replacement) and CAREBANK (Cardiovascular Research Consortium---A Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients),1 in which a total of 671 AVR patients (bioprosthesis, n  = 361 and mecha...
Source: The Journal of Thoracic and Cardiovascular Surgery - March 11, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Suk Jung Choo Tags: Commentary Source Type: research

The prevalence and prognostic significance of interatrial block in the general population.
Discussion IAB is a rather frequent finding in the general population. IAB is a risk factor for AF and is associated with an increased risk of stroke or TIA independently of associated AF. Key messagesBoth partial and advanced interatrial block are associated with increased risk of atrial fibrillation in the general population.Advanced interatrial block is an independent risk factor for stroke and transient ischemic attack.The clinical significance of interatrial block is dependent on the subtype classification. PMID: 32077319 [PubMed - as supplied by publisher]
Source: Annals of Medicine - February 23, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Effectiveness of Only Aspirin or Clopidogrel Following Percutaneous Left Atrial Appendage Closure
Percutaneous left atrial appendage closure (LAAC) offers a feasible option for stroke prevention in patients with atrial fibrillation (AF), but the optimal antithrombotic treatment strategy for patients with strict contraindications to oral anticoagulation (OAC) remains uncertain. We sought to evaluate short- and long-term outcome after percutaneous LAAC in these very patients discharged on single antiplatelet therapy (SAPT) alone. All consenting AF patients who underwent LAAC from February 2009 to August 2018 in Turku University Hospital, Finland, were enrolled into a prospectively maintained registry.
Source: The American Journal of Cardiology - September 25, 2019 Category: Cardiology Authors: Jussi-Pekka Pouru, Samuli Jaakkola, Juha Lund, Fausto Biancari, Antti Saraste, K. E. Juhani Airaksinen Source Type: research

Natural course of Fabry disease with the p. Arg227Ter (p.R227*) mutation in Finland: Fast study
ConclusionCardiac involvement should be effectively detected in females before considering them asymptomatic mutation carriers.
Source: Molecular Genetics & Genomic Medicine - August 13, 2019 Category: Genetics & Stem Cells Authors: P äivi Pietilä‐Effati, Jukka T. Saarinen, Eliisa Löyttyniemi, Reijo Autio, Maria Saarenhovi, Maria K. Haanpää, Ilkka Kantola Tags: ORIGINAL ARTICLE Source Type: research

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

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