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Specialty: Drugs & Pharmacology
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Total 336 results found since Jan 2013.

UPLC-ESI-Q-TOF/MS based metabolic profiling of protosappanin B in rat plasma, bile, feces, urine and intestinal bacteria samples.
CONCLUSION: The results showed that the small intestinal and biliary routes play an important role in the clearance and excretion of PTB. The main sites of metabolism in the PTB chemical structure were the phenolic hydroxyl and the side-chains on the eight-element ring. PMID: 33605854 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - February 19, 2021 Category: Drugs & Pharmacology Authors: Chen WY, Liang GY, Zheng ZL, Wu YS, Xu FF, Liu B, Guo DA Tags: Curr Drug Metab Source Type: research

A Novel Creatinine-Based Equation to Estimate Glomerular Filtration Rate in Chinese Population With Chronic Kidney Disease: Implications for DOACs Dosing in Atrial Fibrillation Patients
Conclusion: Xiangya-s equation provides more accurate GFR estimates in Chinese CKD patients who need consecutive monitoring of renal function, which may assist clinicians in choosing appropriate drug dosages.
Source: Frontiers in Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Source Type: research

Modeling of diagnosis for metabolic syndrome by integrating symptoms into physiochemical indexes
CONCLUSION: Compared with SVM and DT models, the RF model showed the best performance, especially when the ratio of the training set to test set is 8:2. Compared with single predictive indexes, the model constructed by combining physiochemical indexes with TCM indexes (i.e. the fused indexes) exhibited better predictive ability. In addition to common physicochemical indexes, some TCM indexes, such as wiry pulse, chest tightness, spontaneous perspiration, greasy tongue coating, can also improve diagnosis of MS.PMID:33588265 | DOI:10.1016/j.biopha.2021.111367
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 15, 2021 Category: Drugs & Pharmacology Authors: Shu-Jie Xia Bi-Zhen Gao Shui-Hua Wang David S Guttery Can-Dong Li Yu-Dong Zhang Source Type: research

Modeling of diagnosis for metabolic syndrome by integrating symptoms into physiochemical indexes.
CONCLUSION: Compared with SVM and DT models, the RF model showed the best performance, especially when the ratio of the training set to test set is 8:2. Compared with single predictive indexes, the model constructed by combining physiochemical indexes with TCM indexes (i.e. the fused indexes) exhibited better predictive ability. In addition to common physicochemical indexes, some TCM indexes, such as wiry pulse, chest tightness, spontaneous perspiration, greasy tongue coating, can also improve diagnosis of MS. PMID: 33588265 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 12, 2021 Category: Drugs & Pharmacology Authors: Xia SJ, Gao BZ, Wang SH, Guttery DS, Li CD, Zhang YD Tags: Biomed Pharmacother Source Type: research

Effect of Panax notoginseng Saponins on Focal Cerebral Ischemia-Reperfusion in Rat Models: A Meta-Analysis
With the increase of the aging population, the high mortality and disability rates caused by ischemic stroke are some of the major problems facing the world, and they dramatically burden the society. Panax notoginseng (Burk) F. H. Chen, a traditional Chinese medicine, is commonly used for promoting blood circulation and removing blood stasis, and its main bioactive components are Panax notoginseng saponins (PNS). Therefore, we performed a meta-analysis on focal cerebral ischemia-reperfusion animal models established with middle cerebral artery occlusion (MCAO) surgery to evaluate the therapeutic effect of PNS. We systemati...
Source: Frontiers in Pharmacology - February 9, 2021 Category: Drugs & Pharmacology Source Type: research

Hospitalization Expenditures and Out-Of-Pocket Expenses in Patients With Stroke in Northeast China, 2015 –2017: A Pooled Cross-Sectional Study
Conclusion: Stroke imposes a heavy financial burden on both patients and society in Liaoning Province, Northeast China. Results showed that there are some differences in the individual and social economic burden among different types of stroke. In addition, stroke patients share a high proportion of costs through OOP expenses, especially for poor social-economic status patients. Targeted intervention measures and specific policies are needed to reduce the individual and social economic burden of stroke as well as improve equity in health care among different social groups.
Source: Frontiers in Pharmacology - February 5, 2021 Category: Drugs & Pharmacology Source Type: research

Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain
Conclusion: The research of inflammasome/pyroptosis in brain will continue to be the hotspot. We recommend investigating the mechanism of mitochondrial molecules involved in the complex crosstalk of pyroptosis and regulated cell deaths (RCDs) in brain glial cells, which will facilitate the development of effective therapeutic strategies targeting inflammasome/pyroptosis and large-scale clinical trials. Thus, this study presents the trend and characteristic of inflammasome/pyroptosis in brain, which provided a helpful bibliometric analysis for researchers to further studies.
Source: Frontiers in Pharmacology - January 20, 2021 Category: Drugs & Pharmacology Source Type: research

Network pharmacology reveals the mechanism of activity of Tongqiao Huoxue Decoction Extract against middle cerebral artery occlusion-induced cerebral ischemia reperfusion injury
Some clinical therapies such as tissue repair by replacing injured with functional tissues have been reported, yet there is the great explore potential for traditional herbal-induced regeneration with good safety. Tongqiao Huoxue Decoction (TQHXD), a well-known classical traditional Chinese Medicinal formula, has been widely used for clinical treatment of stroke. However, biological activity and mechanisms of action of its constituents towards conferring protection against cerebral ischemia reperfusion (I/R) injury remain unclear. In this present study, we evaluated TQHXD quality using HPLC, then screened for its potential...
Source: Frontiers in Pharmacology - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

Use of Cardiovascular Drugs for Primary and Secondary Prevention of Cardiovascular Disease Among Rural-Dwelling Older Chinese Adults
In conclusion, despite highly prevalent cardiovascular risk factors and CVDs, a fairly low proportion of the rural-dwelling older adults take CV medications for primary and secondary prevention. Notably, TCM products are among the most commonly used CV drugs. These results call for additional efforts to promote implementation of the evidence-based recommendations for prevention of CVDs in the primary care settings.
Source: Frontiers in Pharmacology - December 18, 2020 Category: Drugs & Pharmacology Source Type: research

Clinical characteristics and treatment outcome of COVID-19 patients with stroke in China: A multicenter retrospective study
Publication date: Available online 4 December 2020Source: PhytomedicineAuthor(s): Xin-yu Ji, Yan Ma, Nan-nan Shi, Ning Liang, Ren-bo Chen, Si-hong Liu, Shuai Shi, Gui-hui Wu, Ji-ke Li, Hong Chen, Jing-wei Wang, Hui Na, Ying-chun Zhou, Min-qing Li, Yu-dong Wang, Xiao-mei Hu, Yun-hong Hu, Zhang Liu, Hai-jun Xie, Lin-song Zhang
Source: Phytomedicine - December 5, 2020 Category: Drugs & Pharmacology Source Type: research

Network Pharmacology-Based Analysis of Xiao-Xu-Ming Decoction on the Treatment of Alzheimer ’s Disease
In conclusion, XXMD was found to have the potential to treat AD by targeting multiple AD-related targets and canonical pathways. Fangchinoline and dauricine might be the potential lead compounds in XXMD for the treatment of AD.
Source: Frontiers in Pharmacology - December 4, 2020 Category: Drugs & Pharmacology Source Type: research

Semi-Mechanistic Modeling of HY-021068 Based on Irreversible Inhibition of Thromboxane Synthetase
Conclusion: We established a semi-mechanistic PK/PD model for characterizing the PK of HY-021068 and its anti-platelet effect in beagle dogs. The model can be used to predict the concentration and PAR under different dosage regimen of HY-021068, and might be served as a reference for dose design in the future clinical studies.
Source: Frontiers in Pharmacology - November 30, 2020 Category: Drugs & Pharmacology Source Type: research

Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis.
Abstract Ischemic diseases, such as ischemic heart diseases and ischemic stroke, are the leading cause of death worldwide. Angiogenic therapy is a wide-ranging approach to fighting ischemic diseases. However, compared with anti-angiogenesis therapy for tumors, less attention has been paid to therapeutic angiogenesis. Recently, Traditional Chinese medicine (TCM) has garnered increasing interest for its definite curative effect and low toxicity. A growing number of studies have reported that TCM formulas, extracts, and compounds from herbal medicines exert pro-angiogenic activity, which has been confirmed in a few c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 12, 2020 Category: Drugs & Pharmacology Authors: Bu L, Dai O, Zhou F, Liu F, Chen JF, Peng C, Xiong L Tags: Biomed Pharmacother Source Type: research

Mechanism Study of the Protective Effects of Sodium Tanshinone IIA Sulfonate Against Atorvastatin-Induced Cerebral Hemorrhage in Zebrafish: Transcriptome Analysis
This study also provided evidence of biomarkers involved in hemorrhage stroke and improved understanding of the effects of HMG-COA reductase inhibition on vascular permeability and cerebral hemorrhage.
Source: Frontiers in Pharmacology - October 1, 2020 Category: Drugs & Pharmacology Source Type: research

Emodin in atherosclerosis prevention: Pharmacological actions and therapeutic potential.
Abstract Atherosclerotic plaque formation, destabilization and eventual rupture leads to the acute cardiovascular events including myocardial infarction and stroke. Emodin (PubChem CID#3220), (1,3,8-trihydroxy-6-methylanthracene-9,10-dione) is a pharmacologically bioactive constituent isolated from the traditional Chinese medicinal herb Radix rhizoma Rhei. This molecule has anti-oxidant, anti-inflammatory, anti-proliferative, anti-apoptotic and lipid-modulating effects. Experimental studies have demonstrated that emodin attenuates and stabilizes atherosclerotic plaques. In this mini-review, we provide a summary of...
Source: European Journal of Pharmacology - September 29, 2020 Category: Drugs & Pharmacology Authors: Luo N, Fang J, Wei L, Sahebkar A, Little PJ, Xu S, Luo C, Li G Tags: Eur J Pharmacol Source Type: research