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Effects of comprehensive care measures based on the HAPA model on self-care, neurotransmitters and clinical outcomes in cerebral infarction patients
CONCLUSIONS: Comprehensive care measures of HAPA model may be used with advantage to improve the self-care ability, reduce the degree of neurological damage, and improve neurological function in cerebral infarction patients. Age, hypertension history, and NIHSS score after treatment were all risk factors related to poor prognosis.PMID:37259727 | DOI:10.26355/eurrev_202305_32452
Source: European Review for Medical and Pharmacological Sciences - June 1, 2023 Category: Drugs & Pharmacology Authors: X-H Tian X Chen G-F Jiang Source Type: research

Research trends and hotspots of post-stroke cognitive impairment: A bibliometric analysis
Conclusions: This review provided a comprehensive summary of the literature of PSCI, identified the authoritative and frequently cited literature and journals, clarified the trends in PSCI research, and highlighted the hotspots in this field. Currently, studies on the mechanisms and treatment of PSCI are limited, and we hope that this review has effectively highlighted the research trajectory of PSCI and will lay the foundation for more innovative research in the future.
Source: Frontiers in Pharmacology - May 30, 2023 Category: Drugs & Pharmacology Source Type: research

Huoluo Xiaoling Pellet promotes microglia M2 polarization through increasing MCPIP1 expression for ischemia stroke alleviation
This study aimed to explore whether HXP can promote microglial M2 polarization by upregulating MCPIP1 expression, consequently mitigating cerebral ischemic injury. Our study involved 85 Sprague-Dawley rats (weighing 250-280 g). We established middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation-reoxygenation (OGD/R) models with MCPIP1 knockdown to assess the effects of HXP on ischemic strokes. Our findings show that HXP reduced brain water content, improved neurological function, and inhibited the expression of inflammatory factors in the brain tissues of MCAO rats. The neuroprotective effects of HXP on c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 26, 2023 Category: Drugs & Pharmacology Authors: Wei Shen Xiaoguang Wang Meiqi Tang Lan Yao Chenyu Wan Jianli Niu Pappachan E Kolattukudy Zhuqing Jin Source Type: research

Danhong injection improves neurological function in rats with ischemic stroke by enhancing neurogenesis and activating BDNF/AKT/CREB signaling pathway
In this study, we aimed to determine the effect of DHI on long-term neurological function recovery after cerebral ischemia and explored the related mechanisms. Middle cerebral artery occlusion (MCAO) was used to establish an IS model in rats. The efficacy of DHI was assessed using neurological severity scores, behaviors, cerebral infarction volume and histopathology. Immunofluorescence staining was performed to assess hippocampal neurogenesis. An in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) cell model was constructed and western-blot analyses were performed to verify the underlying mechanisms. Our results show...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 19, 2023 Category: Drugs & Pharmacology Authors: Lan Li Jie-Hong Yang Chang Li Hui-Fen Zhou Li Yu Xiao-Long Wu Yi-Hang Lu Yu He Hai-Tong Wan Source Type: research

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