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Condition: Diabetes
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Total 188 results found since Jan 2013.

Diabetes prevalence and complication rates: In individual First Nations communities in the Sioux Lookout region of Ontario
CONCLUSION: This study demonstrates the possibility of reporting diabetes prevalence by individual First Nations reserve communities. Complication rates can be reported by individual community, but estimates are more useful for comparison if the smallest communities are grouped together. Such studies could be replicated across Canada to promote local use of these data for resource planning and monitoring long-term progress of diabetes programs and services.PMID:34385208 | DOI:10.46747/cfp.6708601
Source: Canadian Family Physician Medecin de Famille Canadien - August 13, 2021 Category: Primary Care Authors: Benjamin T B Chan Sumeet K Sodhi Graham C Mecredy Terri Farrell Janet Gordon Source Type: research

Janssen Submits New Drug Application to U.S. FDA for XARELTO ® (rivaroxaban) to Help Prevent and Treat Blood Clots in Pediatric Patients
RARITAN, NJ, June 23, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for the use of XARELTO® (rivaroxaban) in pediatric patients. The NDA seeks two pediatric indications: treatment of venous thromboembolism (VTE, or blood clots) and reduction in the risk of recurrent VTE in patients aged birth to less than 18 years of age after at least five days of initial parenteral anticoagulant treatment; and thromboprophylaxis (prevention of blood clots) in patients aged 2 years and older with congenita...
Source: Johnson and Johnson - June 23, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Association of diabetes with frequency and cost of hospital admissions: a retrospective cohort study
CMAJ Open. 2021 Apr 16;9(2):E406-E412. doi: 10.9778/cmajo.20190213. Print 2021 Apr-Jun.ABSTRACTBACKGROUND: Acute inpatient hospital admissions account for more than half of all health care costs related to diabetes. We sought to identify the most common and costly conditions leading to hospital admission among patients with diabetes compared with patients without diabetes.METHODS: We used data from the General Internal Medicine Inpatient Initiative (GEMINI) study, a retrospective cohort study, of all patients admitted to a general internal medicine service at 7 Toronto hospitals between 2010 and 2015. The Canadian Institut...
Source: cmaj - April 17, 2021 Category: General Medicine Authors: Jin Choi Gillian Booth Hae Young Jung Lauren Lapointe-Shaw Terence Tang Janice L Kwan Shail Rawal Adina Weinerman Amol Verma Fahad Razak Source Type: research

The Real Maternal Risks in a Pregnancy: A Structured Review to Enhance Maternal Understanding and Education.
Authors: Wilson RD Abstract This review sought to use high-level published data sources for system knowledge translation, collaborative enhanced maternal education and understanding, and prospective maternal quality and safety care planning. The goal was to answer the following question: What are the short- and long-term maternal risks ("near misses," adverse events, severe morbidity and mortality) associated with pregnancy and childbirth? A structured analysis of the literature (systematic review, meta-analysis, observational case-control cohort), focusing on publications between 2016 and April 2019, was undertake...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - July 28, 2020 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

Diabetes-related sex differences in the brain endothelin system following ischemia in vivo and in human brain endothelial cells in vitro.
Abstract The endothelin (ET) system has been implicated to contribute to the pathophysiology of cognitive impairment and stroke in experimental diabetes. Our goals were to test the hypotheses that 1) circulating and/or peri-infarct ET-1 levels are elevated after stroke in both sexes and this increase is greater in diabetes, 2) ET receptors are differentially regulated in the diabetic brain, 3) brain microvascular endothelial cells (BMVEC) of female and male origin express the ETA receptor subtype, and 4) diabetes and stroke-mimicking conditions increase ET-1 levels in BMVECs of both sexes. Control and diabetic rat...
Source: Canadian Journal of Physiology and Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Abdul Y, Li W, Vargas JD, Grant E, He L, Jamil S, Ergul A Tags: Can J Physiol Pharmacol Source Type: research

The Relationship of Sleep Duration with Ethnicity and Chronic Disease in a Canadian General Population Cohort.
Conclusion: Important differences exist in sleep duration between ethnic groups and may contribute to observed health disparities. Our results highlight the need for ethnicity-specific targeted education on the importance of prioritizing sleep for good health, and the need to account appropriately for ethnicity in future epidemiological, clinical, and translational research into sleep and related conditions. PMID: 32346318 [PubMed]
Source: Pain Physician - May 1, 2020 Category: Anesthesiology Authors: Singh M, Hall KA, Reynolds A, Palmer LJ, Mukherjee S Tags: Nat Sci Sleep Source Type: research

Thrombolysis Outcomes in Patients with Diabetes and Previous Stroke: A Meta-Analysis.
PMID: 32234105 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - March 31, 2020 Category: Neurology Authors: Pajo AT, Diestro JDB, Espiritu AI, Dmytriw AA, Enriquez-Marulanda A, Sarmiento RJC, Bagnas MAC, Spears J, San Jose MCZ Tags: Can J Neurol Sci Source Type: research

Endothelin-1 (ET-1) Promotes a Proinflammatory Microglia Phenotype in Diabetic Conditions.
Abstract Diabetes increases the risk and severity of cognitive impairment, especially after ischemic stroke. It is also known that the activation of ET system is associated with cognitive impairment and microglia around periinfarct area produce ET-1. However, little is known about the effect of ET-1 on microglial polarization, especially under diabetic conditions. We hypothesized that a) ET-1 activates microglia to proinflammatory M-1 like phenotype, and b) Hypoxia/LPS activates the microglial ET system and promotes microglial activation towards M-1 phenotype in diabetic conditions. Microglial cells (C8B4) culture...
Source: Canadian Journal of Physiology and Pharmacology - March 1, 2020 Category: Drugs & Pharmacology Authors: Abdul Y, Jamil S, He L, Li W, Ergul A Tags: Can J Physiol Pharmacol Source Type: research

Oral Anticoagulants and Antiplatelet Agents in Atrial Fibrillation Patients with Concomitant Critical Limb Ischemia: A nationwide cohort study
ConclusionsDOAC was associated with a significantly lower risk of composite net-clinical-benefit outcome than either warfarin or APT in AF patients with concomitant CLI. Further prospective study is necessary to validate the findings in the future.
Source: Canadian Journal of Cardiology - February 19, 2020 Category: Cardiology Source Type: research

Cardiovascular Effects of Sodium-Glucose Cotransporter-2 Inhibitors in Adults With Type 2 Diabetes
Publication date: Available online 24 September 2019Source: Canadian Journal of DiabetesAuthor(s): Vincent C. WooAbstractAdults with type 2 diabetes mellitus can benefit from pharmacotherapies that lower their risk for cardiovascular disease. This review describes the salient findings from sodium-glucose cotransporter-2 (SGLT2) inhibitor cardiovascular outcome trials that serendipitously revealed the cardiorenal benefits of SGLT2 inhibitors in adults with type 2 diabetes mellitus who either have established cardiovascular disease or multiple cardiovascular risk factors. It also summarizes the findings from other phase 3 cl...
Source: Canadian Journal of Diabetes - December 13, 2019 Category: Endocrinology Source Type: research

The Cardiovascular Effects of SGLT2 Inhibitors
Publication date: Available online 24 September 2019Source: Canadian Journal of DiabetesAuthor(s): Vincent C. WooAbstractIndividuals with type 2 diabetes mellitus can benefit from pharmacotherapies that lower their risk for cardiovascular disease. This review describes the salient findings from sodium-glucose cotransporter-2 (SGLT2) inhibitor cardiovascular outcome trials that serendipitously revealed the cardiorenal benefits of SGLT2 inhibitors in individuals with type 2 diabetes mellitus who either have established cardiovascular disease or multiple cardiovascular risk factors. It also summarizes the findings from other ...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Forecasting the association of air quality and health outcomes in Ontario
Conclusions: Positive correlations between AQHI and health outcomes are found in this study which revealed that making the public aware of air pollution using AQHI may be helpful to reduce the impact of air pollution in people living with chronic diseases.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Liang, J., Ge, E., Zhu, J., Mcgihon, R., Terebessy, E., Su, Y., To, T. Tags: Occupational and environmental health Source Type: research