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Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer & rsquo;s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids Molecules doi: 10.3390/molecules28155624 Authors: Ryszard Pluta Barbara Miziak Stanisław J. Czuczwar Neurodegeneration of the brain after ischemia is a major cause of severe, long-term disability, dementia, and mortality, which is a global problem. These phenomena are attributed to excitotoxicity, changes in the blood–brain barrier, neuroinflammation, oxidative stress, vasoconstriction, cerebral amyloid angiopathy,...
Source: Molecules - July 25, 2023 Category: Chemistry Authors: Ryszard Pluta Barbara Miziak Stanis ław J. Czuczwar Tags: Review Source Type: research

Lithium Co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3 β activity in a rat model
Free Radic Biol Med. 2023 Jul 4:S0891-5849(23)00522-1. doi: 10.1016/j.freeradbiomed.2023.07.004. Online ahead of print.ABSTRACTCerebral ischemic stroke is one of the leading causes of adult disability worldwide. Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we investigated the efficacy of rutin and lithium co-treatment in improving post-stroke neurological outcomes in a transient global cerebral ischemia-reperfusion injury rat model. Middle-aged male rats were subjected to transient global cerebral ischemia-reperfusion. NORT and Y-maze were used to assess the cognitive process...
Source: Free Radical Biology and Medicine - July 6, 2023 Category: Biology Authors: Anil Kumar Rana Rajneesh Kumar Durgesh Nandan Shukla Damanpreet Singh Source Type: research

Neuroprotection of NAD+ and NBP against ischemia/reperfusion brain injury is associated with restoration of sirtuin-regulated metabolic homeostasis
Conclusions: These results confirmed the protective effects of NAD+ and NBP on cerebral ischemic injury. NBP and NAD+ showed similar antioxidant effects, while NAD+ had better ability in restoring energy metabolism, possibly through upregulating the activity of SIRT1 and SIRT3. The protection provided by NBP against cerebral ischemia/reperfusion may be achieved through SIRT1.
Source: Frontiers in Pharmacology - March 28, 2023 Category: Drugs & Pharmacology Source Type: research

Relationship between the therapeutic potential of various plant-derived bioactive compounds and their related microRNAs in neurological disorders
CONCLUSION: The emergence of miRNAs as pathological regulatory factors provides a new direction for the study of bioactive compounds in Traditional Chinese medicine and the elucidating of their epigenetic effects. Elucidating the regulatory relationship between bioactive compounds and miRNAs may help to identify new therapeutic targets and promoting the application of these compounds in precision medicine through their targeted molecular activity.PMID:36368284 | DOI:10.1016/j.phymed.2022.154501
Source: Atherosclerosis - November 11, 2022 Category: Cardiology Authors: Xiaoyu Dong Jianfei Nao Source Type: research

Discovery of 1,2,4-triazole derivatives as novel neuroprotectants against cerebral ischemic injury by activating antioxidant response element
Bioorg Chem. 2022 Aug 13;128:106096. doi: 10.1016/j.bioorg.2022.106096. Online ahead of print.ABSTRACTAcute ischemic stroke is an important cause of death and long-term disability worldwide. In this work, we have synthesized a series of derivatives with 3,5‑diaryl substituent triazole scaffolds. The derivatives showed favorable protective effective in SNP-induced oxidative stress model, of which compound 5 was the most active. In vivo experiments showed that compound 5 could ameliorate neurological deficits, attenuate infarction sizes, reduce malonaldehyde (MDA) level and increase superoxide dismutase (SOD) level in midd...
Source: Bioorganic Chemistry - August 19, 2022 Category: Chemistry Authors: Yaoqiang Lao Ping Huang Jianwen Chen Yang Wang Ruiqi Su Weiyan Shao Wenhao Hu Jingxia Zhang Source Type: research

Treatment of ischemic stroke with modified mesenchymal stem cells
Int J Med Sci. 2022 Jun 27;19(7):1155-1162. doi: 10.7150/ijms.74161. eCollection 2022.ABSTRACTIschemic stroke is one of the leading causes of death and disability. Ischemia triggers a cascade of events leading to cell death and cerebral infarction. Mesenchymal stem cell (MSC) therapy is a promising treatment modality to promote the development of nerve and blood vessels and improve nerve function. However, MSCs have a limited therapeutic effect in the harsh microenvironment of ischemic brain tissue. Modified MSC therapy shows better therapeutic effect under different pathological conditions, and is expected to be translate...
Source: International Journal of Medical Sciences - August 3, 2022 Category: Biomedical Science Authors: Hao Chen Liangfu Zhou Source Type: research

Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB
Appl Biochem Biotechnol. 2022 Jul 15. doi: 10.1007/s12010-022-04060-x. Online ahead of print.ABSTRACTCerebral ischemia and successive reperfusion are the prevailing cause of cerebral stroke. Currently cerebral stroke is considered to be one of the prior causes for high mortality, disability, and morbidity. Cynaropicrin, a sesquiterpene lactone, exhibits various pharmacologic properties and also has an anti-inflammatory property associated with the suppression of the key pro-inflammatory NF-κB pathway. The protective effect of cynaropicrin against oxidative stress and neuroinflammation during CIR injury through the modulat...
Source: Applied Biochemistry and Biotechnology - July 15, 2022 Category: Biochemistry Authors: Tao Jin Bing Leng Source Type: research

Beta-Boswellic Acid Protects Against Cerebral Ischemia/Reperfusion Injury via the Protein Kinase C Epsilon/Nuclear Factor Erythroid 2-like 2/Heme Oxygenase-1 Pathway
This study demonstrates that β-BA exerts neuroprotective effects against cerebral I/R via the activation of the PRKCE/NFE2L2/HMOX1 pathway and is a potentia l therapeutic candidate for ischemic stroke.Graphical abstract
Source: Molecular Neurobiology - May 3, 2022 Category: Neurology Source Type: research

Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model
Eur J Pharmacol. 2022 Apr 22:174973. doi: 10.1016/j.ejphar.2022.174973. Online ahead of print.ABSTRACTIntracerebral haemorrhagic (ICH) stroke is a major cause of death and disability globally, with no proper treatment available so far. Rutin, a dietary flavonoid, has shown protection against cerebral ischemic stroke due to its antioxidant and anti-inflammatory attributes. However, the efficacy of rutin against ICH stroke remained unexplored. Therefore, in the current study, we investigated the effect of rutin in an ICH stroke zebrafish larva model. The larvae were exposed to atorvastatin (1.25 μM) in system water for indu...
Source: European Journal of Pharmacology - April 26, 2022 Category: Drugs & Pharmacology Authors: Anil Kumar Rana Supriya Sharma Shiv Kumar Saini Damanpreet Singh Source Type: research

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