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Bs-452758-4 combined gene therapy approach targets parasympathetic signaling and oxidative stress to attenuate persistent atrial fibrillation development in a canine model
Atrial fibrillation (AF) is the most common arrhythmia, a major risk factor for stroke and is associated with substantial morbidity and mortality. Unfortunately, current pharmacological and interventional treatment approaches are suboptimal. Parasympathetic nervous system (PNS) activity upregulation and oxidative stress (OS), mainly generated by NADPH oxidase 2 (NOX2), have been shown as key players in AF induction and maintenance. A deeper understanding of these molecular mechanisms underlying AF and their interplay will be instrumental to the development of new, mechanism-targeted therapies for AF.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Aleksei Mikhailov, Azaria Panni, Anna Pfenniger, Shin Yoo, David Johnson, Wenwei Zhang, Markus Rottmann, William Marszalec, Asish Ghosh, Rod S. Passman, Bradley P. Knight, Rishi Arora Source Type: research

Po-626-03 preclinical safety of adkcnh2-g628s for post-op af
Post-operative atrial fibrillation (POAF) occurs in 30% of cardiac surgeries, increasing risk of stroke, MI, and death. We propose gene therapy with an adenovirus encoding the G628S mutation of KCNH2 (AdKCNH2-G628S) to prevent POAF. We have reported preclinical efficacy in pigs.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: J. Kevin Donahue, David D. McManus Source Type: research

Recent Advances in Gene Therapy for Atrial Fibrillation
This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - May 30, 2021 Category: Cardiology Authors: Shin Yoo, Gail Elizabeth Geist, Anna Pfenniger, Markus Rottmann, Rishi Arora Tags: REVIEW Source Type: research

Current Drug Treatment Strategies for Atrial Fibrillation and TASK-1 Inhibition as an Emerging Novel Therapy Option
Atrial fibrillation (AF) is the most common sustained arrhythmia with a prevalence of up to 4% and an upwards trend due to demographic changes. It is associated with an increase in mortality and stroke incidences. While stroke risk can be significantly reduced through anticoagulant therapy, adequate treatment of other AF related symptoms remains an unmet medical need in many cases. Two main treatment strategies are available: rate control that modulates ventricular heart rate and prevents tachymyopathy as well as rhythm control that aims to restore and sustain sinus rhythm. Rate control can be achieved through drugs or abl...
Source: Frontiers in Pharmacology - March 4, 2021 Category: Drugs & Pharmacology Source Type: research

Attenuation of Oxidative Injury with Targeted Expression of NOX2 shRNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation.
Conclusions: NOX2 oxidative injury: a) underlies onset as well as maintenance of electrical remodeling in AF, and b) can be successfully prevented with a novel, gene-based approach. Future optimization of this approach may lead to a novel, mechanism-guided therapy for AF. PMID: 32686471 [PubMed - as supplied by publisher]
Source: Circulation - July 19, 2020 Category: Cardiology Authors: Yoo S, Pfenniger A, Hoffman J, Zhang W, Ng J, Burrell A, Johnson DA, Gussak G, Waugh T, Bull S, Benefield B, Knight BP, Passman R, Wasserstrom JA, Aistrup GL, Arora R Tags: Circulation Source Type: research

Preclinical efficacy and safety of KCNH2-G628S gene therapy for post-operative atrial fibrillation
We examined preclinical efficacy and safety of KCNH2-G628S gene transfer to prevent POAF.
Source: The Journal of Thoracic and Cardiovascular Surgery - May 23, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Zhao Liu, Julie A. Hutt, Barur Rajeshkumar, Yoshihiro Azuma, Kailai L. Duan, J. Kevin Donahue Source Type: research

Preclinical efficacy and safety of KCNH2-G628S gene therapy for postoperative atrial fibrillation
We examined the preclinical efficacy and safety of KCNH2-G628S gene transfer to prevent POAF.
Source: The Journal of Thoracic and Cardiovascular Surgery - May 23, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Zhao Liu, Julie A. Hutt, Barur Rajeshkumar, Yoshihiro Azuma, Kailai L. Duan, J. Kevin Donahue Tags: Evolving technology Source Type: research

Therapeutic Prospects of Gene Therapy for Atrial Fibrillation
Atrial Fibrillation (AF) is one of the most common types of cardiac arrhythmias experienced in clinical practice, increasing the risk of stroke, dementia, myocardial infarction and death. Currently available options for the treatment of AF use either pharmacological agents or catheter-based ablation therapies to restore sinus rhythm or control the ventricular response rate. These current treatment options are suboptimal at best, motivating research into discovering more effective and innovative ways to treat AF.
Source: Heart, Lung and Circulation - May 11, 2016 Category: Cardiology Authors: Melad Farraha, James J.H. Chong, Eddy Kizana Source Type: research

Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

The Use of Gene Therapy for Ablation of Atrial Fibrillation
In the United States, atrial fibrillation (AF) is the most common sustained cardiac arrhythmia affecting approximately six million patients and contributing to a greatly increased risk of stroke, heart failure (HF) and overall morbidity and mortality.1,2 The prevalence of AF is increasing as the average age of the population increases.3,4
Source: Radcliffe Cardiology - November 25, 2014 Category: Cardiology Authors: lravichander Source Type: research

The Year in Review of Clinical Cardiac Electrophysiology
This past year saw multiple important advances in the field clinical cardiac electrophysiology. Seminal articles describing new anticoagulant drugs for stroke prevention in atrial fibrillation were published. New results that raise questions regarding the safety of dronedarone and several new promising techniques in AF ablation were described. Important articles that refine our understanding of the risk of sudden death among Wolff-Parkinson-White patients were published. In the basic and translational sciences, the application of gene therapy to the study and potential treatment of arrhythmias was described, whereas geneti...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - February 11, 2013 Category: Cardiology Source Type: research