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Condition: Vertigo
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Total 456 results found since Jan 2013.
Rapid Identification of Novel Inhibitors of the Human Aquaporin‐1 Water Channel
This article is protected by copyright. All rights reserved.
Aquaporin (AQP) channels play critical roles in several normal physiological and pathological states involving rapid water transport and are therefore drug targets. A high‐throughput cell‐based screening on > 6000 small molecular weight compounds identified several AQP1 blockers. Compared to canonical mercurial compounds, water transport assay in vesicles (Figure) identified two groups of most active novel AQP1 inhibitors e.g. a sulfonamide (compound 2), which constitute attractive leads for developing small‐molecule functional modulators for human AQP1.
Source: Chemical Biology and Drug Design - December 19, 2015 Category: Biology Authors: Rajkumar V. Patil, Shouxi Xu, Alfred N. van Hoek, Andrew Rusinko, Zixia Feng, Jesse May, Mark Hellberg, Najam A. Sharif, Martin B. Wax, Macarena Irigoyen, Grant Carr, Tom Brittain, Peter Brown, Damon Colbert, S. Kumari, K. Varadaraj, Alok K. Mitra Tags: Research Article Source Type: research
Vestibular projections: Beyond the reflex
Vestibular function is mainly assessed through its reflex action, particularly on the eyes. However, cognitive/perceptual effects are also recognized, which are likely to be mediated by projections to the cortex via the thalamus. JC,1 for example, who documented his own loss of vestibular function due to streptomycin, while much disturbed by oscillopsia, also had difficulty in judging his own orientation and that of the surroundings, including slopes. The otolith organs of the vestibular apparatus—the saccule and the utricle—are the body's linear accelerometers, including detecting the effect of gravity. The in...
Source: Neurology - January 11, 2016 Category: Neurology Authors: Colebatch, J. G., Halmagyi, G. M., Lorenzano, S. Tags: MRI, Other cerebrovascular disease/ Stroke, All Neurotology, Vertigo EDITORIALS Source Type: research
The Under-Utilization of the Head Impulse Test in the Emergency Department.
DISCUSSION: Despite good published evidence regarding its use the HIT is under-utilized in the ER. Physicians need to be aware of the HIT and newer video HITs and make use of them in practice.
PMID: 26787132 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - January 20, 2016 Category: Neurology Authors: McDowell T, Moore F Tags: Can J Neurol Sci Source Type: research
Your NEJM Group Today: ABIM Exam Results, Stroke After Peripheral Vertigo, Cleveland Hospitalist Opportunities (FREE)
By the Editors
NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Knowledge+ Blog: If you were one of …
Source: Physician's First Watch current issue - February 5, 2016 Category: Primary Care Source Type: news
Challenges in the pharmacological management of epilepsy and its causes in the elderly.
Publication date: Available online 16 February 2016 Source:Pharmacological Research Author(s): Edoardo Ferlazzo, Chiara Sueri, Sara Gasparini, Umberto Aguglia Epilepsy represents the third most common neurological disorders in the elderly after cerebrovascular disorders and dementias. The incidence of new-onset epilepsy peaks in this age group. The most peculiar aetiologies of late-onset epilepsy are stroke, dementia, and brain tumours. However, aetiology remains unknown in about half of the patients. Diagnosis of epilepsy may be challenging due to the frequent absence of ocular witnesses and the high prevalence of s...
Source: Pharmacological Research - February 17, 2016 Category: Drugs & Pharmacology Source Type: research
Unique presentation of LHON/MELAS overlap syndrome caused by m.13046T>C in MTND5.
CONCLUSIONS: We describe a unique presentation of LHON/MELAS overlap syndrome resulting from a m.13046T>C mutation in a 12-year-old girl. In patients with sudden vision loss in which three of the most prevalent LHON mitochondrial mutations have been ruled out, molecular genetic examination should be extended to other mtDNA-encoded subunits of MTND5 complex I. Furthermore, atypical clinical presentations must be considered, even in well-described phenotypes.
PMID: 26894521 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - February 20, 2016 Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
Challenges in the pharmacological management of epilepsy and its causes in the elderly
Publication date: April 2016 Source:Pharmacological Research, Volume 106 Author(s): Edoardo Ferlazzo, Chiara Sueri, Sara Gasparini, Umberto Aguglia Epilepsy represents the third most common neurological disorders in the elderly after cerebrovascular disorders and dementias. The incidence of new-onset epilepsy peaks in this age group. The most peculiar aetiologies of late-onset epilepsy are stroke, dementia, and brain tumours. However, aetiology remains unknown in about half of the patients. Diagnosis of epilepsy may be challenging due to the frequent absence of ocular witnesses and the high prevalence of seizure-mimi...
Source: Pharmacological Research - February 25, 2016 Category: Drugs & Pharmacology Source Type: research
Advances in the Pathogenesis, Diagnosis and Treatment of Bow Hunter's Syndrome: A Comprehensive Review of the Literature
Bow hunter's syndrome (BHS), also known as rotational vertebral artery (VA) occlusion syndrome, is a rare yet treatable type of symptomatic vertebrobasilar insufficiency resulting from mechanical occlusion or stenosis of the VA during head and neck rotation or extension. The symptoms of BHS range from transient vertigo to posterior circulation stroke. The underlying pathology is dynamic stenosis or compression of the VA by abnormal bony structures with neck rotation or extension in many cases, such as osteophyte, disc herniation, cervical spondylosis, tendinous bands or tumors. Imaging approaches, such as Doppler sonograph...
Source: Interventional Neurology - March 3, 2016 Category: Neurology Source Type: research
Vestibular vertigo and comorbid cognitive and psychiatric impairment: the 2008 National Health Interview Survey
Conclusions
Our findings indicate that vestibular impairment is associated with increased risk of cognitive and psychiatric comorbidity. The vestibular system is anatomically connected with widespread regions of the cerebral cortex, hippocampus and amygdala. Loss of vestibular inputs may lead to impairment of these cognitive and affective circuits. Further longitudinal research is required to determine if these associations are causal.
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 15, 2016 Category: Neurosurgery Authors: Bigelow, R. T., Semenov, Y. R., du Lac, S., Hoffman, H. J., Agrawal, Y. Tags: Dementia, Drugs: CNS (not psychiatric), Stroke, Anxiety disorders (including OCD and PTSD), Memory disorders (psychiatry), Ear, nose and throat/otolaryngology Neuropsychiatry Source Type: research
Acute vestibular syndrome: a critical review and diagnostic algorithm concerning the clinical differentiation of peripheral versus central aetiologies in the emergency department
Abstract
Almost 20 % of cerebral ischaemic strokes occur in the posterior circulation. Estimates are that 20 % of these patients present with isolated vertigo. In approximately one-sixth to one-third of these patients, this symptom is wrongly diagnosed to be peripheral vestibular in origin. As a result, these missed stroke patients are withheld from therapeutic and secondary prophylactic treatment, which may result in unnecessary morbidity and mortality. We therefore propose a diagnostic algorithm concerning the clinical differentiation of acute vestibular syndrome (AVS) patients based on a critical review of th...
Source: Journal of Neurology - March 16, 2016 Category: Neurology Source Type: research
Benign Paroxysmal Positional Vertigo after Dental Procedures: A Population-Based Case-Control Study
Conclusions Our results demonstrated a correlation between dental procedures and BPPV. The specialists who treat patients with BPPV should consider dental procedures to be a risk factor, and dentists should recognize BPPV as a possible complication of dental treatment.
Source: PLoS One - April 3, 2016 Category: Biomedical Science Authors: Tzu-Pu Chang Source Type: research
An Uncommon Cause for Multiple Cerebral Ischemic Infarcts (P4.344)
Conclusions: Cerebral infarcts due to CM in immunocompetent patients are unusual. However, cryptococcal infection should be considered in atypical stroke manifestations, since early diagnosis and prompt treatment can improve outcome.Disclosure: Dr. Khattak has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Wise has nothing to disclose. Dr. Moore has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Wilder has nothing to disclose. Dr. Remmel has nothing to disclose. Dr. Liu has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Khattak, J., Desai, M., Desai, D., Wise, E., Moore, K., Shah, J., Wilder, M., Remmel, K., Liu, W. Tags: Cerebrovascular Case Reports Source Type: research
Matrix Metalloproteinase Levels in Cervical and Intracranial Carotid Dolichoarteriopathies (P4.371)
Conclusions: MMP-2 may play a role in the etiology of DE or kink /tortuosity of carotid artery may cause elevation of MMP-2 in plasma. MMP-12 levels increases in carotid atherosclerotic lesions and may lead plaque formation. In future, MMP inhibitor therapies may appear to be a choice for the treatment of atherosclerotic plaques or DE.Disclosure: Dr. Arslan has nothing to disclose. Dr. Arslan has nothing to disclose. Dr. Pekçevik has nothing to disclose. Dr. Şener has nothing to disclose. Dr. Köse has nothing to disclose. Dr. Zorlu has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Arslan, Y., Arslan, I. B., Pekcevik, Y., Şener, U., Kose, Şukran, Zorlu, Y. Tags: Cerebrovascular Case Reports Source Type: research
A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine
ConclusionIn this retrospective study, triptans and DHE were used with no reported, subsequent acute/subacute ischemic vascular events for the abortive treatment of migraines with basilar and hemiplegic‐type features. Although the small sample sizes generated theoretical statistical event rates of 4.5% for BM and 23% for HM, there has been no clear evidence that BM and HM carry an actual elevated risk for vascular events compared with migraine with aura.
Source: Headache: The Journal of Head and Face Pain - February 29, 2016 Category: Neurology Authors: Paul G. Mathew, Regina Krel, Bhuvin Buddhdev, Hossein Ansari, Shivang G. Joshi, Warren D. Spinner, Brad C. Klein Tags: Research Submissions Source Type: research
Clinical Reasoning: A 76-year-old man with acute-onset left-sided weakness and numbness
A 76-year-old right-handed man with no known medical problems presented 2 hours after falling at work due to the acute onset of left-sided weakness and numbness. He had experienced left knee pain the previous day, but denied vertigo, headache, neck pain, chest pain, abdominal pain, or back pain. On examination, his blood pressure was 230/118 mm Hg; pulse and respiratory rate were normal. He was anxious with normal mentation, no carotid bruits, normal cardiac rate and rhythm, clear lung fields, normal cranial nerves including facial strength, weakness in his left leg (2/5 power) and arm (4/5 power), sensory loss to painful ...
Source: Neurology - April 10, 2016 Category: Neurology Authors: Renthal, W., Alberts, M., Shang, T. Tags: All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research
