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Association of High Homocysteine Levels With the Risk Stratification in Hypertensive Patients at Risk of Stroke.
Abstract PURPOSE: We aimed to investigate the association between stroke morbidity and different stratifications of classic risk factors, such as increasing age, body mass index (BMI), blood lipids, and blood glucose, in hypertensive patients with high homocysteine levels. METHODS: A cross-sectional study of 2258 patients with primary hypertension were enrolled in this study, including 871 stroke cases (62.89%) in 1385 hypertensive patients without hyperhomocysteinemia (HHcy) and 647 (74.11%) stroke cases in 873 hypertensive patients with HHcy. Basic information of patients were collected, including age, sex,...
Source: Clinical Therapeutics - March 23, 2016 Category: Drugs & Pharmacology Authors: Pang H, Han B, Fu Q, Zong Z Tags: Clin Ther Source Type: research

Stroke patients ’ support: evaluation of knowledge, practices and training needs of French community pharmacists
Conclusion Based on this small study, the fragmented knowledge and varied practices promote the need for further training for pharmacists to optimize support of stroke patients. This study promotes the elaboration of training systems adapted to pharmacists ’ needs. This will help support the development of a targeted pharmaceutical care approach for stroke patients.
Source: International Journal of Clinical Pharmacy - January 2, 2021 Category: Drugs & Pharmacology Source Type: research

Botulinum Toxin Type A for the Treatment of Lower Limb Spasticity after Stroke
AbstractPost-stroke lower limb spasticity impairs balance and gait leading to reduced walking speed, often increasing wheelchair use and caregiver burden. Several studies have shown that appropriate treatments for lower limb spasticity after stroke include injections of botulinum toxin type A (BoNT-A), phenol or alcohol, surgical correction and a rehabilitation program. In the present article, we review the safety and effectiveness of BoNT-A for the treatment of lower limb spasticity after stroke, with a focus on higher doses of BoNT-A. The cumulative body of evidence coming from the randomized clinical trials and open-lab...
Source: Drugs - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

Primary Prevention of Ischaemic Stroke in Atrial Fibrillation: New Oral Anticoagulant Drugs for all?
Abstract Atrial fibrillation (AF) confers a 4.5% risk of stroke per year. The risk of stroke increases with various risk factors and until recently, warfarin has been the gold standard of thromboembolism prophylaxis in AF for many years. The dosage of warfarin requires regular adjustment dependent on the INR, to keep within a narrow therapeutic range of 2.0- 3.0. The INR can be altered by concomitant drugs, foods and alcohol and requires inconvenient blood monitoring. Underanticoagulation places patients at risk of stroke, whilst over-anticoagulation confers significant bleeding risk. Consequently approximately ha...
Source: Current Vascular Pharmacology - May 24, 2014 Category: Drugs & Pharmacology Authors: Foley J, Kirchhof P, Lip GY Tags: Curr Vasc Pharmacol Source Type: research

Role of Calcium Homeostasis in Ischemic Stroke: A Review.
Abstract Stroke is the second most common cause of death worldwide. It occurs due to the insufficient supply of oxygen-rich blood to the brain. It is a complex disease with multiple associated risk factors including smoking, alcoholism, age, sex, ethnicity, etc. Calcium ions are known to play a vital role in cell death pathways, which is a ubiquitous intracellular messenger during and immediately after an ischemic period. Disruption in normal calcium hemostasis is known to be a major initiator and activator of the ischemic cell death pathway. Under Ischemic stroke conditions, glutamate is released from the neurons...
Source: CNS and Neurological Disorders Drug Targets - February 12, 2021 Category: Drugs & Pharmacology Authors: Ludhiadch A, Sharma R, Muriki A, Munshi A Tags: CNS Neurol Disord Drug Targets Source Type: research

Comparison of the risk of cardiovascular diseases, stroke, and diabetes among the selected group of football referees and the group of general population men from Northern Poland - a pilot study
CONCLUSIONS: Thanks to properly planned and systematically continued physical activity, despite non-compliance with certain pro-health principles (increased sweet supply and consumption of alcoholic beverages), football referees are characterized by the correct body fat volume and low level of visceral adipose tissue. The parameters were found to be markedly higher in the control group of randomly selected men from the general population. The risk of diabetes, stroke, and cardiovascular diseases among football referees was found to be very low.PMID:35587065 | DOI:10.26355/eurrev_202205_28732
Source: Pharmacological Reviews - May 19, 2022 Category: Drugs & Pharmacology Authors: J Weso łowska A Jurczak S Wieder-Huszla K Jarosz A Jurewicz M Marchlewicz Source Type: research

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