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Specialty: Chemistry
Condition: Thrombosis
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Total 16 results found since Jan 2013.

Thrombus inhibition and neuroprotection for ischemic stroke treatment through platelet regulation and ROS scavenging
This study may provide a promising therapeutic routine for regulating the microenvironment of ischemic stroke through a combined function of ROS scavenging, microthrombus inhibition, and BBB penetration.PMID:36220787 | DOI:10.1002/cmdc.202200317
Source: ChemMedChem - October 11, 2022 Category: Chemistry Authors: Hongbo Ye Zhifang Ma Lei Liu Tianci Zhang Qiaoyi Han Zehong Xiang Yu Xia Yue Ke Xinghua Guan Qiang Shi Fazly I Ataullakhanov Mikhail Panteleev Source Type: research

Molecules, Vol. 27, Pages 5488: The Effect of a New N-hetero Cycle Derivative on Behavior and Inflammation against the Background of Ischemic Stroke
Kiseleva Vadim V. Negrebetsky Yuri I. Baukov Ischemic stroke triggers a whole cascade of pathological changes in the brain, one of which is postischemic inflammation. Since in such cases thrombolytic therapy is often not possible, methods that modulate inflammation and affect microglia become particularly interesting. We synthesized 3-(2-oxo-4-phenylpyrrolidin-1-yl)propane-1-sulfonate calcium(II) (Compound 4) and studied its anti-inflammatory activity in in vitro and in vivo models of inflammation and ischemia. Macrophage cell line RAW 264.7 was treated with lipopolysaccharides (LPS) and Compound 4 at various dosa...
Source: Molecules - August 26, 2022 Category: Chemistry Authors: Denis A. Borozdenko Tatiana A. Shmigol Aiarpi A. Ezdoglian Darya I. Gonchar Natalia. Y. Karpechenko Dmitri N. Lyakhmun Anastasia D. Shagina Elvira A. Cherkashova Daria D. Namestnikova Ilya L. Gubskiy Anastasia A. Chernysheva Nina M. Kiseleva Vadim V. Negr Tags: Article Source Type: research

Vitamin D and its possible relationship to neuroprotection in COVID-19: evidence in the literature
Curr Top Med Chem. 2022 Apr 1. doi: 10.2174/1568026622666220401140737. Online ahead of print.ABSTRACTVitamin D is a hormone involved in the regulation of important biological processes such as signal transduction, immune response, metabolic regulation and also in the nervous and vascular systems. To date, coronavirus disease 2019 (COVID-19) infection does not have a specific treatment, however various drugs have been proposed, including those that attenuate the intense inflammatory response and recently the use of vitamin D, in clinical trials, as part of the treatment of COVID-19 has provided promising results. It has bee...
Source: Current Topics in Medicinal Chemistry - April 3, 2022 Category: Chemistry Authors: Saray Quintero-Fabi án Cindy Bandala Luz Adriana Pichardo-Mac ías Itzel Jatziri Contreras-Garc ía Sa úl Gómez-Manzo Beatriz Hern ández-Ochoa Jos é Arturo Martínez-Orozco Iv án Ignacio-Mejía Noem í Cárdenas-Rodríguez Source Type: research

Synthesis and evaluation of novel and potent protease activated receptor 4 (PAR4) antagonists based on a quinazolin-4(3H)-one scaffold
In this study, we explored the activity of quinazolin-4(3H)-one-based PAR4 antagonists, beginning with their IDT analogues. By repeated structural optimisation, we developed a series of highly selective PAR4 antagonists with nanomolar potency on human platelets. Of these, 13 and 30g, with an 8-benzo[d]thiazol-2-yl-substituted quinazolin-4(3H)-one structure, showed optimal activity (h. PAR4-AP PRP IC50 = 19.6 nM and 6.59 nM, respectively) on human platelets. Furthermore, 13 and 30g showed excellent selectivity for PAR4 versus PAR1 and other receptors (IC50s > 10 μM) on human platelets. And 13 and 30g were lack of cross-...
Source: European Journal of Medicinal Chemistry - August 14, 2021 Category: Chemistry Authors: Shangde Liu Duo Yuan Shanshan Li Roujie Xie Yi Kong Xiong Zhu Source Type: research

Study of ultrasound thrombolysis of blood clots using acoustic bubbles
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D1LC00276G, PaperYuan Gao, Mengren Wu, Bruce Gaynes, Robert S Dieter, Jie Xu Thrombosis is a common medical entity associated with many forms of cardiovascular disease including myocardial infarction and stroke. Recently, ultrasound thrombolysis has emerged as a promising technique for thrombosis treatment... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - July 22, 2021 Category: Chemistry Authors: Yuan Gao Source Type: research

Ischemic stroke disrupts the endothelial glycocalyx through activation of proHPSE via acrolein exposure Molecular Bases of Disease
In this study, glycosaminoglycans, a component of the endothelial glycocalyx, were studied in the context of ischemic stroke using a photochemically induced thrombosis mouse model. Decreased levels of heparan sulfate and chondroitin sulfate and increased activity of hyaluronidase 1 and heparanase (HPSE) were observed in ischemic brain tissues. HPSE expression in cerebral vessels increased after stroke onset and infarct volume greatly decreased after co-administration of N-acetylcysteine + glycosaminoglycan oligosaccharides as compared with N-acetylcysteine administration alone. These results suggest that the endothelial gl...
Source: Journal of Biological Chemistry - December 25, 2020 Category: Chemistry Authors: Kenta Ko, Takehiro Suzuki, Ryota Ishikawa, Natsuko Hattori, Risako Ito, Kenta Umehara, Tomomi Furihata, Naoshi Dohmae, Robert J. Linhardt, Kazuei Igarashi, Toshihiko Toida, Kyohei Higashi Tags: Glycobiology and Extracellular Matrices Source Type: research

MicroRNAs in Venous Thrombo-Embolism.
Abstract BACKGROUND: Venous Thrombo-embolism (VTE) is the major preventable cause of death and disability worldwide. It has the third highest incidence rate of hospital death after coronary artery disease (CAD) and stroke. With the establishment of Virchow's triad stating the major factors responsible for VTE including stasis, hypercoagulability and endothelial dysfunction, the last decade reported number of studies regarding its diagnosis and prophylaxis. Till date the most commonly used clinical marker for its diagnosis is the D-dimer test, detecting endogenous fibrinolysis. This test often gives false positive ...
Source: International Journal of Clinical Chemistry - January 31, 2020 Category: Chemistry Authors: Angelina Hembrom A, Srivastava S, Garg I, Kumar B Tags: Clin Chim Acta Source Type: research

Activated protein C assays: a review.
Abstract Activated protein C (APC) acts as an "on demand" anticoagulant, reducing thrombin formation. Reduced plasma levels of APC or protein C (PC) are associated with an increased risk of venous thromboembolism. APC also displays cytoprotective functions and its therapeutic use has been evaluated in severe sepsis and is under evaluation in several diseases with an important inflammatory component. In addition, different studies have revealed a potential role of PC/APC in disorders such as obesity, pneumonia, disseminated intravascular coagulation, Alzheimer, stroke, etc. Accordingly, the therapeutic value of dif...
Source: International Journal of Clinical Chemistry - November 11, 2019 Category: Chemistry Authors: Oto J, Fernández-Pardo Á, Miralles M, Plana E, España F, Navarro S, Medina P Tags: Clin Chim Acta Source Type: research

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review.
Abstract Direct oral anticoagulants (DOACs) are first-line drugs used for the treatment of venous thromboembolism and prevention of stroke in patients with atrial fibrillation. These drugs do not require the regular biochemical monitoring that is mandatory for warfarin, and they exhibit shorter half-lives and have a faster onset of action. Since recent real-world studies evidence a higher prevalence of adverse side effects than what was anticipated in clinical trials, monitoring the plasma concentrations of DOACs is being used to personalize their pharmacotherapy, in accordance to the characteristics of the patien...
Source: Analytica Chimica Acta - June 19, 2019 Category: Chemistry Authors: Gouveia F, Bicker J, Gonçalves J, Alves G, Falcão A, Fortuna A Tags: Anal Chim Acta Source Type: research

Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia.
This article reviews current research and developments regarding small molecular compounds, including natural products and newly synthesized compounds that have neuroprotective effects and potential molecular targets for the recovery of post-ischemic stroke neural function that have been identified through lab investigations conducted during the last five years. Although pre-clinical studies of these compounds may not be immediately successful, current findings suggest that these therapeutic targets and neuroprotective agents are promising. PMID: 30445263 [PubMed - as supplied by publisher]
Source: European Journal of Medicinal Chemistry - November 7, 2018 Category: Chemistry Authors: Luo Y, Tang H, Li H, Zhao R, Huang Q, Liu J Tags: Eur J Med Chem Source Type: research

Molecules, Vol. 23, Pages 374: Inhibitory Effect of Flavonolignans on the P2Y12 Pathway in Blood Platelets
k-Bijak Adenosine diphosphate (ADP) is the major platelet agonist, which is important in the shape changes, stability, and growth of the thrombus. Platelet activation by ADP is associated with the G protein-coupled receptors P2Y1 and P2Y12. The pharmacologic blockade of the P2Y12 receptor significantly reduces the risk of peripheral artery disease, myocardial infarction, ischemic stroke, and vascular death. Recent studies demonstrated the inhibition of ADP-induced blood platelet activation by three major compounds of the flavonolignans group: silybin, silychristin, and silydianin. For this reason, the aim of the curren...
Source: Molecules - February 10, 2018 Category: Chemistry Authors: Michal Bijak Rafal Szelenberger Angela Dziedzic Joanna Saluk-Bijak Tags: Article Source Type: research

Synthesis, Anticlotting and Antiplatelet Effects of 1,2,3-Triazoles Derivatives.
CONCLUSION: 1,2,3-triazoles are potential candidates for molecular modeling of new antithrombotic drugs. PMID: 27140186 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - May 1, 2016 Category: Chemistry Authors: de Andrade Moura L, de Almeida AC, da Silva AV, de Souza VR, Ferreira VF, Menezes MV, Kaiser CR, Ferreira SB, Fuly AL Tags: Med Chem Source Type: research