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Specialty: Chemistry
Condition: Thrombosis

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Total 34 results found since Jan 2013.

Microfluidic device with reconfigurable spatial temporal gradients reveals plastic astrocyte response to stroke and reperfusion
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00276D, PaperCatherine Reed-McBain, Rithvik V Turaga, Seth Zima, Sara Abizanda Campo, Jeremiah Riendeau, Emmanuel Contreras Guzman, Terry Juang, Duane S. Juang, David Hampton, Melissa Skala, Jose M Ayuso As a leading cause of mortality and morbidity, stroke constitutes a significant global health burden. Ischemic stroke accounts for 80% of cases and occurs due to an arterial thrombus, which... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - July 8, 2023 Category: Chemistry Authors: Catherine Reed-McBain Source Type: research

Molecules, Vol. 28, Pages 4953: Electrochemical Disposable Biosensor to Monitor Dabigatran in Point-of-Care Anticoagulation Therapy
riero Dabigatran etexilate, an oral prodrug, is often used to treat complications linked to thrombosis. Dabigatran (DAB, active form) does not need to be monitored. However, there are several conditions, such as reduced renal function, traumatic bleeding, emergency surgery, the need for thrombolytic therapy in acute stroke, or the requirement to use other forms of anticoagulation, where knowing the concentration of DAB in the blood is indispensable. Unfortunately, there are no convenient DAB-specific point-of-care tests available. To solve this problem, two disposable sensors were constructed and optimised in this work...
Source: Molecules - June 23, 2023 Category: Chemistry Authors: Ashwin K. V. Mruthunjaya Ronald C. Chatelier Angel A. J. Torriero Tags: Article Source Type: research

Thrombus inhibition and neuroprotection for ischemic stroke treatment through platelet regulation and ROS scavenging
This study may provide a promising therapeutic routine for regulating the microenvironment of ischemic stroke through a combined function of ROS scavenging, microthrombus inhibition, and BBB penetration.PMID:36220787 | DOI:10.1002/cmdc.202200317
Source: ChemMedChem - October 11, 2022 Category: Chemistry Authors: Hongbo Ye Zhifang Ma Lei Liu Tianci Zhang Qiaoyi Han Zehong Xiang Yu Xia Yue Ke Xinghua Guan Qiang Shi Fazly I Ataullakhanov Mikhail Panteleev Source Type: research

Molecules, Vol. 27, Pages 5488: The Effect of a New N-hetero Cycle Derivative on Behavior and Inflammation against the Background of Ischemic Stroke
Kiseleva Vadim V. Negrebetsky Yuri I. Baukov Ischemic stroke triggers a whole cascade of pathological changes in the brain, one of which is postischemic inflammation. Since in such cases thrombolytic therapy is often not possible, methods that modulate inflammation and affect microglia become particularly interesting. We synthesized 3-(2-oxo-4-phenylpyrrolidin-1-yl)propane-1-sulfonate calcium(II) (Compound 4) and studied its anti-inflammatory activity in in vitro and in vivo models of inflammation and ischemia. Macrophage cell line RAW 264.7 was treated with lipopolysaccharides (LPS) and Compound 4 at various dosa...
Source: Molecules - August 26, 2022 Category: Chemistry Authors: Denis A. Borozdenko Tatiana A. Shmigol Aiarpi A. Ezdoglian Darya I. Gonchar Natalia. Y. Karpechenko Dmitri N. Lyakhmun Anastasia D. Shagina Elvira A. Cherkashova Daria D. Namestnikova Ilya L. Gubskiy Anastasia A. Chernysheva Nina M. Kiseleva Vadim V. Negr Tags: Article Source Type: research

Vitamin D and its possible relationship to neuroprotection in COVID-19: evidence in the literature
Curr Top Med Chem. 2022 Apr 1. doi: 10.2174/1568026622666220401140737. Online ahead of print.ABSTRACTVitamin D is a hormone involved in the regulation of important biological processes such as signal transduction, immune response, metabolic regulation and also in the nervous and vascular systems. To date, coronavirus disease 2019 (COVID-19) infection does not have a specific treatment, however various drugs have been proposed, including those that attenuate the intense inflammatory response and recently the use of vitamin D, in clinical trials, as part of the treatment of COVID-19 has provided promising results. It has bee...
Source: Current Topics in Medicinal Chemistry - April 3, 2022 Category: Chemistry Authors: Saray Quintero-Fabi án Cindy Bandala Luz Adriana Pichardo-Mac ías Itzel Jatziri Contreras-Garc ía Sa úl Gómez-Manzo Beatriz Hern ández-Ochoa Jos é Arturo Martínez-Orozco Iv án Ignacio-Mejía Noem í Cárdenas-Rodríguez Source Type: research

Gut Microbiota and Cardiovascular Disease: Symbiosis Versus Dysbiosis
Curr Med Chem. 2021 Dec 12. doi: 10.2174/0929867328666211213112949. Online ahead of print.ABSTRACTThe gut microbiome interacts with host physiology through various mechanisms, including the cardiovascular (CV) system. A healthy microbiome has the ability to process and digest complex carbohydrates into short-chain fatty acids (SCFA). These SCFA function as signaling molecules, immune-modulating molecules, and energy sources. However, when the microbiome is altered, it produces gut dysbiosis with overgrowth of certain bacteria that may lead to overproduction of trimethylamine-N-oxide (TMAO) from the metabolism of phosphatid...
Source: Current Medicinal Chemistry - December 28, 2021 Category: Chemistry Authors: Antonis A Manolis Theodora A Manolis Helen Melita Antonis S Manolis Source Type: research

Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs
Eur J Med Chem. 2021 Dec 7;228:114035. doi: 10.1016/j.ejmech.2021.114035. Online ahead of print.ABSTRACTMany populations suffer from thrombotic disorders such as stroke, myocardial infarction, unstable angina and thromboembolic disease. Thrombus is one of the major threatening factors to human health and the prevalence of cardio-cerebrovascular diseases induced by thrombus is growing worldwide, even some persons got rare and severe blood clots after receiving the AstraZeneca COVID vaccine unexpectedly. In terms of mechanism of thrombosis, antithrombotic drugs have been divided into three categories including anticoagulants...
Source: European Journal of Medicinal Chemistry - December 13, 2021 Category: Chemistry Authors: Xiaoan Li Tiantian Guo Qian Feng Tiantian Bai Lei Wu Yubo Liu Xu Zheng Jianzhong Jia Jin Pei Shaoping Wu Yiming Song Yongmin Zhang Source Type: research

Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery
Ultrason Sonochem. 2021 Oct 21;80:105805. doi: 10.1016/j.ultsonch.2021.105805. Online ahead of print.ABSTRACTRecent advances in ultrasound (US) have shown its great potential in biomedical applications as diagnostic and therapeutic tools. The coupling of ultrasound-assisted drug delivery systems with nanobiomaterials possessing tailor-made functions has been shown to remove the limitations of conventional drug delivery systems. The low-frequency ultrasound has significantly enhanced the targeted drug delivery effect and efficacy, reducing limitations posed by conventional treatments such as a limited therapeutic window. Th...
Source: Ultrasonics Sonochemistry - October 27, 2021 Category: Chemistry Authors: Sze Shin Low Chang Nong Lim Maxine Yew Wai Siong Chai Liang Ee Low Sivakumar Manickam Beng Ti Tey Pau Loke Show Source Type: research

Synthesis and evaluation of novel and potent protease activated receptor 4 (PAR4) antagonists based on a quinazolin-4(3H)-one scaffold
In this study, we explored the activity of quinazolin-4(3H)-one-based PAR4 antagonists, beginning with their IDT analogues. By repeated structural optimisation, we developed a series of highly selective PAR4 antagonists with nanomolar potency on human platelets. Of these, 13 and 30g, with an 8-benzo[d]thiazol-2-yl-substituted quinazolin-4(3H)-one structure, showed optimal activity (h. PAR4-AP PRP IC50 = 19.6 nM and 6.59 nM, respectively) on human platelets. Furthermore, 13 and 30g showed excellent selectivity for PAR4 versus PAR1 and other receptors (IC50s > 10 μM) on human platelets. And 13 and 30g were lack of cross-...
Source: European Journal of Medicinal Chemistry - August 14, 2021 Category: Chemistry Authors: Shangde Liu Duo Yuan Shanshan Li Roujie Xie Yi Kong Xiong Zhu Source Type: research