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Condition: Thrombosis

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Total 34 results found since Jan 2013.

Novel potent antiplatelet thrombotic agent derived from biguanide for ischemic stroke.
Abstract Platelet thrombosis is the main pathogeny resulting in the low curability of ischemic stroke, a leading cause of mortality and disability worldwide. Metformin, a biguanide derivative that is the first-line oral medicine for type 2 diabetes, alleviates the severity of ischemic stroke in diabetic patients and suppresses platelet activation in experimental animal model. However, the clinical implementation of commercial biguanide analogs for stroke related to platelet thrombosis remains challenging due to its weak potency, poor pharmacokinetic characteristics and possible hypoglycemia. Here, twenty-three big...
Source: European Journal of Medicinal Chemistry - May 17, 2020 Category: Chemistry Authors: Xin G, Ming Y, Ji C, Wei Z, Li S, Morris-Natschke SL, Zhang X, Yu K, Li Y, Zhang B, Zhang J, Xing Z, He Y, Chen Z, Yang X, Niu H, Lee KH, Huang W Tags: Eur J Med Chem Source Type: research

Minocycline Repurposing in Critical Illness: Focus on Stroke.
Abstract Stroke is a devastating disease associated with high morbidity and mortality. Despite the approved indication of systemic thrombolytic therapy in the United States for the acute management of ischemic stroke, its use is limited given a strict eligibility criteria and a risk for hemorrhagic transformation as a feared adverse effect. Many agents have been studied without success for neuroprotection in patients with stroke to reduce vascular injury and improve long-term functional outcomes. Minocycline is a tetracycline antibiotic that shows promise for its neuroprotective effects in multiple animal models a...
Source: Current Topics in Medicinal Chemistry - September 20, 2013 Category: Chemistry Authors: Vivian Liao T, C Forehand C, Hess DC, Fagan SC Tags: Curr Top Med Chem Source Type: research

Ischemic stroke disrupts the endothelial glycocalyx through activation of proHPSE via acrolein exposure Molecular Bases of Disease
In this study, glycosaminoglycans, a component of the endothelial glycocalyx, were studied in the context of ischemic stroke using a photochemically induced thrombosis mouse model. Decreased levels of heparan sulfate and chondroitin sulfate and increased activity of hyaluronidase 1 and heparanase (HPSE) were observed in ischemic brain tissues. HPSE expression in cerebral vessels increased after stroke onset and infarct volume greatly decreased after co-administration of N-acetylcysteine + glycosaminoglycan oligosaccharides as compared with N-acetylcysteine administration alone. These results suggest that the endothelial gl...
Source: Journal of Biological Chemistry - December 25, 2020 Category: Chemistry Authors: Kenta Ko, Takehiro Suzuki, Ryota Ishikawa, Natsuko Hattori, Risako Ito, Kenta Umehara, Tomomi Furihata, Naoshi Dohmae, Robert J. Linhardt, Kazuei Igarashi, Toshihiko Toida, Kyohei Higashi Tags: Glycobiology and Extracellular Matrices Source Type: research

Molecules, Vol. 27, Pages 5488: The Effect of a New N-hetero Cycle Derivative on Behavior and Inflammation against the Background of Ischemic Stroke
Kiseleva Vadim V. Negrebetsky Yuri I. Baukov Ischemic stroke triggers a whole cascade of pathological changes in the brain, one of which is postischemic inflammation. Since in such cases thrombolytic therapy is often not possible, methods that modulate inflammation and affect microglia become particularly interesting. We synthesized 3-(2-oxo-4-phenylpyrrolidin-1-yl)propane-1-sulfonate calcium(II) (Compound 4) and studied its anti-inflammatory activity in in vitro and in vivo models of inflammation and ischemia. Macrophage cell line RAW 264.7 was treated with lipopolysaccharides (LPS) and Compound 4 at various dosa...
Source: Molecules - August 26, 2022 Category: Chemistry Authors: Denis A. Borozdenko Tatiana A. Shmigol Aiarpi A. Ezdoglian Darya I. Gonchar Natalia. Y. Karpechenko Dmitri N. Lyakhmun Anastasia D. Shagina Elvira A. Cherkashova Daria D. Namestnikova Ilya L. Gubskiy Anastasia A. Chernysheva Nina M. Kiseleva Vadim V. Negr Tags: Article Source Type: research

Anti-inflammatory Target of a Novel Thrombolytic Stroke Drug Enzymology
Although ischemic stroke is a major cause of death and disability worldwide, only a small fraction of patients benefit from the current thrombolytic therapy due to a risk of cerebral hemorrhage caused by inflammation. Thus, the development of a new strategy to combat inflammation during thrombolysis is an urgent demand. The small molecule thrombolytic SMTP-7 effectively treats ischemic stroke in several animal models with reducing cerebral hemorrhage. Here we revealed that SMTP-7 targeted soluble epoxide hydrolase (sEH) to suppress inflammation. SMTP-7 inhibited both of the two sEH enzyme activities: epoxide hydrolase (whi...
Source: Journal of Biological Chemistry - December 26, 2014 Category: Chemistry Authors: Matsumoto, N., Suzuki, E., Ishikawa, M., Shirafuji, T., Hasumi, K. Tags: Enzymology Source Type: research

Biomarkers associated with stroke risk in atrial fibrillation.
Abstract Atrial fibrillation is associated with increased risk for cardioembolic stroke. The risk of cardioembolism is not adequately reduced with the administration of oral anticoagulants, since a number of patients continue to experience thromboembolic events despite receiving anti-thrombotic treatment. Several biomarkers have been proposed to predict cardioembolic stroke in patients with atrial fibrillation. Some of them are already used in the clinical practice, such as D-Dimers, Troponin and brain natriuretic peptide. Novel ones such as the inflammatory growth differentiation factor-15, appear to be promising...
Source: Current Medicinal Chemistry - July 18, 2017 Category: Chemistry Authors: Ioannou A, Papageorgiou N, Falconer D, Rehal O, Sewart E, Zacharia E, Toutouzas K, Vlachopoulos C, Siasos G, Tsioufis C, Tousoulis D Tags: Curr Med Chem Source Type: research

Thrombus inhibition and neuroprotection for ischemic stroke treatment through platelet regulation and ROS scavenging
This study may provide a promising therapeutic routine for regulating the microenvironment of ischemic stroke through a combined function of ROS scavenging, microthrombus inhibition, and BBB penetration.PMID:36220787 | DOI:10.1002/cmdc.202200317
Source: ChemMedChem - October 11, 2022 Category: Chemistry Authors: Hongbo Ye Zhifang Ma Lei Liu Tianci Zhang Qiaoyi Han Zehong Xiang Yu Xia Yue Ke Xinghua Guan Qiang Shi Fazly I Ataullakhanov Mikhail Panteleev Source Type: research

Microfluidic device with reconfigurable spatial temporal gradients reveals plastic astrocyte response to stroke and reperfusion
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00276D, PaperCatherine Reed-McBain, Rithvik V Turaga, Seth Zima, Sara Abizanda Campo, Jeremiah Riendeau, Emmanuel Contreras Guzman, Terry Juang, Duane S. Juang, David Hampton, Melissa Skala, Jose M Ayuso As a leading cause of mortality and morbidity, stroke constitutes a significant global health burden. Ischemic stroke accounts for 80% of cases and occurs due to an arterial thrombus, which... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - July 8, 2023 Category: Chemistry Authors: Catherine Reed-McBain Source Type: research

Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia.
This article reviews current research and developments regarding small molecular compounds, including natural products and newly synthesized compounds that have neuroprotective effects and potential molecular targets for the recovery of post-ischemic stroke neural function that have been identified through lab investigations conducted during the last five years. Although pre-clinical studies of these compounds may not be immediately successful, current findings suggest that these therapeutic targets and neuroprotective agents are promising. PMID: 30445263 [PubMed - as supplied by publisher]
Source: European Journal of Medicinal Chemistry - November 7, 2018 Category: Chemistry Authors: Luo Y, Tang H, Li H, Zhao R, Huang Q, Liu J Tags: Eur J Med Chem Source Type: research

MicroRNAs in Venous Thrombo-Embolism.
Abstract BACKGROUND: Venous Thrombo-embolism (VTE) is the major preventable cause of death and disability worldwide. It has the third highest incidence rate of hospital death after coronary artery disease (CAD) and stroke. With the establishment of Virchow's triad stating the major factors responsible for VTE including stasis, hypercoagulability and endothelial dysfunction, the last decade reported number of studies regarding its diagnosis and prophylaxis. Till date the most commonly used clinical marker for its diagnosis is the D-dimer test, detecting endogenous fibrinolysis. This test often gives false positive ...
Source: International Journal of Clinical Chemistry - January 31, 2020 Category: Chemistry Authors: Angelina Hembrom A, Srivastava S, Garg I, Kumar B Tags: Clin Chim Acta Source Type: research

Platelets And Atherothrombosis: Causes, Targets And Treatments For Thrombosis.
Abstract Arterial thrombosis is the acute complication that develops on the chronic lesions of atherosclerosis and reasons heart attack and stroke, today the most common causes of mortality in developed countries. According to the WHO, 17.1 million people died world wide of cardiovascular diseases (CVD), per year, accounting for one-third of all deaths globally. On the basis of current estimates from the American Heart Association, more than 60 million people in the United States alone have one or more forms of cardiovascular disease, and a high proportion of these individuals are at increased risk of arterial thr...
Source: Current Medicinal Chemistry - April 1, 2013 Category: Chemistry Authors: Siddiqui TI, Anil Kumar KS, Dikshit DK Tags: Curr Med Chem Source Type: research

Post-translational Protein Modifications of Rare and Unconventional Types: Implications in Functions and Diseases.
Abstract Protein post-translational modification (PTM) occurs following their biosynthesis and is a key cellular event that defines their ultimate functional properties. It is an important control mechanism for display of biological functions of proteins often in a profound manner. It may switch on or off a protein's function. Several studies have been conducted to understand their mechanisms, physiological pathways and functional properties. PTMs have been shown to alter structural, conformational and physicochemical properties of proteins. So far a variety of protein modifications have been detected in physiolog...
Source: Current Medicinal Chemistry - January 17, 2016 Category: Chemistry Authors: Basak S, Lu C, Basak A Tags: Curr Med Chem Source Type: research

Synthesis, Anticlotting and Antiplatelet Effects of 1,2,3-Triazoles Derivatives.
CONCLUSION: 1,2,3-triazoles are potential candidates for molecular modeling of new antithrombotic drugs. PMID: 27140186 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - May 1, 2016 Category: Chemistry Authors: de Andrade Moura L, de Almeida AC, da Silva AV, de Souza VR, Ferreira VF, Menezes MV, Kaiser CR, Ferreira SB, Fuly AL Tags: Med Chem Source Type: research