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Specialty: Respiratory Medicine
Condition: Thrombosis

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Total 80 results found since Jan 2013.

COVID-19 and Its Implications for Thrombosis and Anticoagulation
Semin Respir Crit Care Med DOI: 10.1055/s-0041-1722992Venous thromboembolism, occlusion of dialysis catheters, circuit thrombosis in extracorporeal membrane oxygenation (ECMO) devices, acute limb ischemia, and isolated strokes, all in the face of prophylactic and even therapeutic anticoagulation, are features of novel coronavirus disease 2019 (COVID-19) coagulopathy. It seems well established at this time that a COVID-19 patient deemed sick enough to be hospitalized, should receive at least prophylactic dose anticoagulation. However, should some hospitalized patients have dosage escalation to intermediate dose? Should some...
Source: Seminars in Respiratory and Critical Care Medicine - February 6, 2021 Category: Respiratory Medicine Authors: Berkman, Samuel A. Tapson, Victor F. Tags: Review Article Source Type: research

Aggressive Therapy for Acute Pulmonary Embolism: Systemic Thrombolysis and Catheter-Directed Approaches
This article reviews current clinical evidence and societal guidelines for the use of systemic and catheter-directed thrombolysis for treatment of acute PE. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Respiratory and Critical Care Medicine - February 6, 2021 Category: Respiratory Medicine Authors: Todoran, Thomas M. Petkovich, Bradley Tags: Review Article Source Type: research

Transverse sinus mass misinterpreted as the source of cardiac emboli.
Authors: Allam HH, Kinsara AJ, Alrajawi A, Tuaima T, Vriz O Abstract Due to the proximity of the transvers sinus (TS) to the left atrial appendage (LAA) and pulmonary veins (PV), a mass in the TS can be misinterpreted as a LAA or PV thrombus, and considered as a source of emboli in a patient with stroke or transient ischemic attack. The incorrect identification of a mass as a LAA thrombus would initiate unnecessary anticoagulation therapy or potentially, an evaluation for the excision of the mass if there is a concern about dislodgement. We are presenting a case illustrating this confusion and review the literature...
Source: Monaldi Archives for Chest Disease - January 23, 2021 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Isolated pulmonary embolism is associated with a high risk of arterial thrombotic disease - Results from the VTEval Study.
Abstract BACKGROUND: Isolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of venous thromboembolism (VTE). RESEARCH QUESTION: We hypothesized that the presence of isolated PE may signal a chronically elevated risk of arterial thrombotic disease. STUDY DESIGN AND METHODS: Data from the VTEval Study, a prospective cohort study enrolling individuals with clinical suspicion and imaging-based diagnosis or exclusion of VTE, were analyzed. Patients with PE received whole-leg ultrasonography to assess presence of deep vein thrombosis (DVT). Regularized logistic regr...
Source: Chest - March 22, 2020 Category: Respiratory Medicine Authors: Cate VT, Eggebrecht L, Schulz A, Panova-Noeva M, Lenz M, Koeck T, Rapp S, Arnold N, Lackner KJ, Konstantinides S, Espinola-Klein C, Münzel T, Prochaska JH, Wild PS Tags: Chest Source Type: research

Increased platelet activation in sleep apnea subjects with intermittent hypoxemia
ConclusionsIncreased platelet activation was present in otherwise healthy subjects with intermittent nocturnal hypoxemia due to underlying OSA. This prothrombotic milieu in the vasculature is likely a key contributing factor toward development of thrombosis and cardiovascular disease.Trial registrationNCT00859950
Source: Sleep and Breathing - February 7, 2020 Category: Respiratory Medicine Source Type: research

Comparing the Effectiveness and Safety of Non-Vitamin K Antagonist Oral Anticoagulants and Warfarin in the Elderly Asian Patients with Atrial Fibrillation: A Nationwide Cohort Study.
CONCLUSIONS: Compared to warfarin, NOACs were associated with a significantly lower risk of adverse events, with heterogeneity in treatment effects among different age strata. Overall, the clear safety signal in favor of NOACs over warfarin was evident irrespective of age strata, being most marked in the most elderly. PMID: 31809694 [PubMed - as supplied by publisher]
Source: Chest - December 2, 2019 Category: Respiratory Medicine Authors: Chao TF, Chiang CE, Liao JN, Chen TJ, Lip GYH, Chen SA Tags: Chest Source Type: research

Bronchoscopic delivery of aminocaproic acid as a treatment for pulmonary bleeding: A case series
ConclusionsEndobronchial administration of ε-aminocaproic acid during bronchoscopy may be a safe and efficacious option in the treatment and prevention of pulmonary bleeding. Further studies are necessary to better define ε-aminocaproic acid's safety profile, optimal routes of administration, and comparative effectiveness to tranexamic acid.
Source: Pulmonary Pharmacology and Therapeutics - November 26, 2019 Category: Respiratory Medicine Source Type: research

Hypercoagulation as the main cause of death in COPD
Conclusion: In the literature there are many data on the main causes of death for patients with COPD, such as respiratory failure, lung cancer, pulmonary thromboembolism, but due to the high comorbidity of COPD with cardiovascular pathology, and the mechanism of mutual complications of these nosologies, according to our research, today the main causes of death for patients with COPD are cardiovascular accidents caused by hypercoagulation.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Abduganieva, E., Artikov, D., Liverko, I. Tags: Monitoring airway disease Source Type: research

Poor enhancement pattern of left atrial appendage in cardiac computed tomography is associated with stroke in persistent atrial fibrillation patients.
Conclusions: The LAA enhancement pattern observed using cardiac CT is associated with the risk of stroke. Poor enhancement in the LAA suggests a potential high risk of stroke. PMID: 31559034 [PubMed]
Source: Journal of Thoracic Disease - September 28, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Pacemaker-detected atrial fibrillation burden and risk of ischemic stroke or thromboembolic events—A cohort study
ConclusionIn patients with dual-chamber pacemakers and comparable CHA2DS2-VASc score, pacemaker-detected AF burden is associated with elevated risk for thromboembolism. Further research is needed to clarify how pacemaker-detected AF burden could incorporate with CHA2DS2-VASc score variables and help to guide anticoagulation.
Source: Heart and Lung: The Journal of Acute and Critical Care - August 1, 2019 Category: Respiratory Medicine Source Type: research

Direct acting oral anticoagulants (DOACs) in critically ill patients.
Abstract The direct acting oral anticoagulants (DOACs) have been increasingly utilized over vitamin K antagonists (VKA) in recent years because they do not require monitoring and have an immediate anti-coagulation effect. In general, DOACs have shown a better safety profile and non-inferiority for venous thromboembolism (VTE) prophylaxis and treatment, and stroke prevention in patients with atrial fibrillation, when compared to VKA agents in the non-ICU population. Whether this holds true in patients who are critically ill remains unknown. In this review, we will address the role of DOACs in special ICU population...
Source: Chest - June 24, 2019 Category: Respiratory Medicine Authors: Rali P, Gangemi A, Moores A, Mohrien K, Moores L Tags: Chest Source Type: research

Effectiveness and Safety of Four Direct Oral Anticoagulants in Asians with Non-valvular Atrial Fibrillation.
CONCLUSIONS: In the largest real-world practice study among Asians with NVAF, four DOACs were associated with lower risks of thromboembolism and bleeding than warfarin. There was consistency even amongst high risk subgroups and whether standard dose or low dose regimes were compared. PMID: 31103697 [PubMed - as supplied by publisher]
Source: Chest - May 15, 2019 Category: Respiratory Medicine Authors: Chan YH, Lee HF, See LC, Tu HT, Chao TF, Yeh YH, Wu LS, Kuo CT, Chang SH, Lip GYH Tags: Chest Source Type: research

Long-term impact of newly diagnosed atrial fibrillation during critical care: A Korean nationwide cohort study.
CONCLUSION: The patients who survived after newly diagnosed AF during critical care remained at a higher risk of long-term stroke/SE and mortality than the patients without AF regardless of AF recurrence and the causes of critical care. Close follow-up and continuous anticoagulation might be needed for these patients. PMID: 31051171 [PubMed - as supplied by publisher]
Source: Chest - April 29, 2019 Category: Respiratory Medicine Authors: Kim K, Yang PS, Jang E, Yu HT, Kim TH, Uhm JS, Kim JY, Sung JH, Pak HN, Lee MH, Lip GYH, Joung B Tags: Chest Source Type: research

The prognostic value of Red cell distribution width(RDW) in acute pulmonary thromboembolism
Conclusion: High RDW level is associated with higher 30 and 90 days mortality rate in acute PT patients. This marker could be considered as a valuable prognostic factor in acute PE.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Parsa, S., Hosseinvand, N., Peiman, S. Tags: Pulmonary embolism Source Type: research

Non-Contrast Chest CT Scans In Detection Of Pulmonary Thromboembolism
Conclusion: Non-contrast chest CT scans have good role in evaluation of PE through detection the hyperdense lumen sign that is a good indicator of acute pulmonary thromboembolism particularly in cases involving the central pulmonary arteries or peripheral wedge shaped opacity as useful indirect sign.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Shaaban, L., Othman, M. H. M., Abozaid, H., Mohamed, N. D. Tags: Pulmonary embolism Source Type: research