Isolated pulmonary embolism is associated with a high risk of arterial thrombotic disease - Results from the VTEval Study.

Isolated pulmonary embolism is associated with a high risk of arterial thrombotic disease - Results from the VTEval Study. Chest. 2020 Mar 23;: Authors: Cate VT, Eggebrecht L, Schulz A, Panova-Noeva M, Lenz M, Koeck T, Rapp S, Arnold N, Lackner KJ, Konstantinides S, Espinola-Klein C, Münzel T, Prochaska JH, Wild PS Abstract BACKGROUND: Isolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of venous thromboembolism (VTE). RESEARCH QUESTION: We hypothesized that the presence of isolated PE may signal a chronically elevated risk of arterial thrombotic disease. STUDY DESIGN AND METHODS: Data from the VTEval Study, a prospective cohort study enrolling individuals with clinical suspicion and imaging-based diagnosis or exclusion of VTE, were analyzed. Patients with PE received whole-leg ultrasonography to assess presence of deep vein thrombosis (DVT). Regularized logistic regression identified features that discriminate between isolated PE and other VTE phenotypes at clinical presentation. Survival analyses were performed to evaluate the crude and adjusted 3-year risks of arterial thrombotic disease, recurrent VTE, and death. RESULTS: The sample comprised 510 patients. Isolated PE patients (n=63) had a distinct clinical profile from patients with other VTE phenotypes (n=447). Chronic obstructive pulmonary disease (COPD), peripheral artery disease, atrial fibrillation and coronary artery disease w...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research

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Authors: Saito I PMID: 32493882 [PubMed - as supplied by publisher]
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Abiomed said it has received approval for an IDE to start an early feasibility study of what it is calling the “world’s smallest heart pump.”   The Danvers, MA-based company said the first-in-human trial will look at the 9 French Impella ECP heart pump in high-risk percutaneous coronary intervention (PCI) patients.   The primary endpoint of the study is successful delivery, initiation, and maintenance of adequate hemodynamic support and a composite rate of major device-related adverse events during high-risk PCI.   The stu...
Source: MDDI - Category: Medical Devices Tags: Cardiovascular Regulatory and Compliance Source Type: news
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Authors: Zhang J, Liu XL, So M, Reder LM Abstract High-complexity stimuli are thought to place extra demands on working memory when processing and manipulating such stimuli; however, operational definitions of complexity are not well established, nor are the measures that would demonstrate such effects. Here, we argue that complexity is a relative quantity that is affected by preexisting experience. Experiment 1 compared cued-recall performance for Chinese and English speakers when the stimuli involved Chinese features that varied in the number of strokes or involved Ethiopic features unfamiliar to both groups. Chi...
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We describe a 34-year-old female who developed an aggressive enlargement of a VS 1 month after GKS. The patient was treated with an immediate external ventric ular drainage and surgical resection via retrosigmoid approach for an acute neurological deterioration due to hydrocephalus and brainstem compression. Histopathological examination revealed a VS with abundant intratumoral thrombosis and necrosis, suggesting that its rapid expansion could be related to massive radiation-induced tumor necrosis. The present case indicated that rapid life-threating enlargement of a VS may occur as an early complication following GKS.
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