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Specialty: Respiratory Medicine
Condition: Thrombosis

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Total 80 results found since Jan 2013.

Venous thromboembolism in patients with idiopathic pulmonary fibrosis, based on nationwide claim data
CONCLUSION: Ischemic heart disease, ischemic stroke, and malignancy, especially lung cancer, were related to higher HR for VTE in IPF.PMID:36846942 | DOI:10.1177/17534666231155772
Source: Respiratory Care - February 27, 2023 Category: Respiratory Medicine Authors: Jang Ho Lee Hoon Hee Lee Hyung Jun Park Seonok Kim Ye-Jee Kim Jae Seung Lee Ho Cheol Kim Source Type: research

A Novel Anti-Thrombotic, Glenzocimab, in Covid-19 acute respiratory distress syndrome (Cov-ARDS).
Conclusion: The GARDEN study was set up to tackle a global Public Health emergency. Glenzocimab was safe in doses three times higher than used in stroke. Albeit efficacy was not shown, overall, GARDEN provides insights into Cov-ARDS.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Pottecher, J., Sato, V. A. H., Pletan, Y., Comenducci, A., Desort-Henin, V., Jandrot-Perrus, M., Binay, S., Meilhoc, A., Avenard, G. Tags: 02.01 - Acute critical care Source Type: research

Colchicine and the combination of rivaroxaban and aspirin in patients hospitalised with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial
Lancet Respir Med. 2022 Oct 10:S2213-2600(22)00298-3. doi: 10.1016/S2213-2600(22)00298-3. Online ahead of print.ABSTRACTBACKGROUND: COVID-19 disease is accompanied by a dysregulated immune response and hypercoagulability. The Anti-Coronavirus Therapies (ACT) inpatient trial aimed to evaluate anti-inflammatory therapy with colchicine and antithrombotic therapy with the combination of rivaroxaban and aspirin for prevention of disease progression in patients hospitalised with COVID-19.METHODS: The ACT inpatient, open-label, 2 × 2 factorial, randomised, controlled trial was done at 62 clinical centres in 11 countries. Patient...
Source: Respiratory Care - October 13, 2022 Category: Respiratory Medicine Authors: John W Eikelboom Sanjit S Jolly Emilie P Belley-Cote Richard P Whitlock Sumathy Rangarajan Lizhen Xu Laura Heenan Shrikant I Bangdiwala Maria Luz Diaz Rafael Diaz Afzalhussein Yusufali Sanjib Kumar Sharma Wadea M Tarhuni Mohamed Hassany Alvaro Avezum Will Source Type: research

Point of care ultrasound detection of thrombus straddling a patent foramen ovale in a patient with acute chest syndrome
We report a case of a young woman with sickle cell disease who was hospitalized for vaso-occlusive crisis and subsequently developed worsening acute chest syndrome and stroke, discovered on point of care ultrasound to have right heart failure and a thrombus straddling a patent foramen oval. POCUS is highly specific for the detection of right heart dilation/dysfunction and should be a routine component of the assessment of acutely decompensating patients.PMID:36017251 | PMC:PMC9396226 | DOI:10.1016/j.rmcr.2022.101724
Source: Respiratory Care - August 26, 2022 Category: Respiratory Medicine Authors: Matthew Gorgone Enrico M Novelli Simmi Patel Phillip E Lamberty Laura M De Castro Mark T Gladwin Stephanie I Maximous Source Type: research

Anticoagulation for Venous Thromboembolism: Impact on the Risk of Major Adverse Cardiovascular Events
Chest. 2022 Jun 14:S0012-3692(22)01087-X. doi: 10.1016/j.chest.2022.05.038. Online ahead of print.ABSTRACTBACKGROUND: It was recently established that patients who developed venous thromboembolism (VTE) are at increased risk of major adverse cardiovascular events (MACE) than the general population. However, whether the anticoagulation used for VTE influences the risk of MACE remains undescribed.RESEARCH QUESTION: Does the anticoagulant treatment for VTE impact the risk of subsequent MACE?STUDY DESIGN AND METHODS: We included patients from a large prospective cohort, who received only one family of anticoagulant treatment a...
Source: Chest - June 17, 2022 Category: Respiratory Medicine Authors: Steve Raoul Noumegni Raphael Le Mao Claire de Moreuil Cl ément Hoffmann Emmanuelle Le Moigne C écile Tromeur Vincent Mansourati Bahaa Nasr Md Jean-Christophe Gentric Marie Guegan Elise Poulhazan Luc Bressollette Karine Lacut Romain Didier Francis Coutur Source Type: research

Aortic thrombosis: the forgotten source of ischemic stroke. A case report and systematic review of the literature
Monaldi Arch Chest Dis. 2021 Dec 3. doi: 10.4081/monaldi.2021.2090. Online ahead of print.ABSTRACTIschemic stroke represents one of the most important health problems in industrialized countries, both for epidemiological and socio-economic impact. The presence of thrombi in the aorta is rare and its treatment has not been uniquely defined. Here we report the case of an 82-years-old man with aortic thrombosis and acute ischemic stroke.PMID:34865461 | DOI:10.4081/monaldi.2021.2090
Source: Monaldi Archives for Chest Disease - December 6, 2021 Category: Respiratory Medicine Authors: Christian Basile Costantino Mancusi Paola Gargiulo Pasquale Perrone Filardi Cinzia Perrino Grazia Canciello Maria Angela Losi Giovanni Esposito Source Type: research

Risk contribution of comorbidities in hospitalized patients with Covid 19 pneumonia
Background: The Covid 19 pandemic has a vast socioeconomic impact worldwide. Obtaining information about the course of the disease is vital for better management.Aim: To assess the risk, comorbidities (CMs) and mortality in hospitalized patients with Covid 19 pneumonia.Methods: The information was gathered from the medical registry and statistical analysis was performed using SPSS.Results: A total of 337 patient were analyzed. Males were 197 (58,5%). Positive PCR results had 307 (91,1%) patients. Almost half of the patients were with respiratory failure on admission (47,1%). At least one comorbidity was found in 84,6%. Fro...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Kyuchukov, N., Krachunov, I., Ivanova, Z., Ignatova-Danova, T., Glogovska, P., Pavlov, P., Popova, T., Ivanov, Y. Tags: Respiratory infections and bronchiectasis Source Type: research

Thromboembolic events in COVID-19 patients : A Tunisian case series study
Coronavirus disease 2019 (COVID-19) can lead to systemic coagulation activation and thrombotic complications(TC), which may lead to fatal outcomes if not diagnosed and managed appropriately.We aimed to report the incidence and characteristics of venous and arterial thrombotic complications(TC) in hospitalized patients with COVID-19 and to investigate the predictive factors of their occurrence.A retrospective study including 200 patients with COVID-19 confirmed by a reverse transcription polymerase chain reaction test, admitted between March 2020 and January 2021 in the pulmonary departement B at Abderrahman Mami Hospi...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Louhaichi, S., Ferchichi, M., Khalfallah, I., Belkhir, S., Boubaker, N., Ammar, J., Hamdi, B., Hamzaoui, A. Tags: Respiratory infections and bronchiectasis Source Type: research

Controversies over the impact of the COVID-19 pandemic on patients with Pulmonary Arterial Hypertension
This study is a retrospective analysis of our PAH patients treated in 2020 compared to the dynamics of the last 12 years. We had 48 PAH patients, 51.72±16.64 years, 72.91% female. All patients had chronic anticoagulant therapy(58.33%) and/or antiplatelet; 33.33% had long term oxygen therapy. Three patients with secondary forms were confirmed with COVID-19, all hospitalized (6.25% infection rate versus 3.29% in general). One patient died(75 years with scleroderma, stroke), two patients were cured (mild forms). In total only three patients died in 2020. Surprisingly, compared with 2008-2019 (101 patients/ 41 deaths, 3...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Bertici, N. S., Dobrescu, L., Pislaru, L., Marincu, I. Tags: Pulmonary hypertension Source Type: research

Direct oral anticoagulant use in special populations
Purpose of review The pivotal phase III trials demonstrating efficacy and safety of direct oral anticoagulants (DOACs) in the treatment of venous thromboembolism (VTE) or nonvalvular atrial fibrillation (NVAF) excluded patients with important and common comorbidities, including obesity, advanced chronic kidney disease, cirrhosis, cancer and antiphospholipid antibody syndrome. Despite the lack of large prospective randomized control trials in these patient populations, the use of DOACs has led to a wealth of efficacy and safety data within these groups. Recent findings Retrospective studies, meta-analyses, nation...
Source: Current Opinion in Pulmonary Medicine - August 11, 2021 Category: Respiratory Medicine Tags: DISORDERS OF THE PULMONARY CIRCULATION: Edited by Steven D. Nathan, Christopher King and Oksana A. Shlobin Source Type: research

Outcomes related to anticoagulation management for mechanical valve replacements
CONCLUSIONS: Taking into account relevant comorbidities and valve type, patients with a larger proportion of non-therapeutic INRs during the first post-operative year demonstrated no difference in longitudinal clinical outcomes. Further research into more standardized INR monitoring and potentially expanded INR target ranges for patients undergoing mechanical valve replacement is warranted.PMID:34164179 | PMC:PMC8182532 | DOI:10.21037/jtd-20-2562
Source: Journal of Thoracic Disease - June 24, 2021 Category: Respiratory Medicine Authors: Lauren V Huckaby Laura M Seese Thomas G Gleason Ibrahim Sultan Yisi Wang Floyd Thoma Arman Kilic Source Type: research