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Atrial cardiomyopathy and incident ischemic stroke risk: a systematic review and meta-analysis
ConclusionAtrial cardiomyopathy markers, including electrocardiographic markers, serum markers, LA structural and functional markers, can be used to stratify the risk of incident ischemic stroke.
Source: Journal of Neurology - April 4, 2023 Category: Neurology Source Type: research

Cerebral venous thrombosis: Associations between disease severity and cardiac markers
Conclusions In this single-center cohort study, markers of CVT severity were associated with increased odds of cTn elevation; further investigation is needed to elucidate causality and significance.
Source: Neurology Clinical Practice - April 5, 2020 Category: Neurology Authors: Johansen, M. C., Gottesman, R. F., Urrutia, V. C. Tags: Other cerebrovascular disease/ Stroke, All Clinical Neurology, All Cerebrovascular disease/Stroke, Cerebral venous thrombosis Research Source Type: research

T2*-Weighted MRI Detected Dilated Cerebral Veins in a Patient With Acute-Phase Cerebral Venous Sinus Thrombosis —A Case Report
We describe a 45-year-old man who presented with nausea, vomiting, and strong occipital headache on the right side. Although no abnormalities on neurological examination or computed tomography imaging were found on admission, peripheral blood cell counts showed polycythemia (hemoglobin 20.6 g/dL) and electrocardiography demonstrated atrial fibrillation. Therefore, anticoagulant treatment with heparin was started immediately. On the following day, the occipital headache continued. Brain T2*-weighted (T2*WI) magnetic resonance imaging (MRI) and, to a lesser extent, susceptibility-weighted imaging showed dilation of numerous ...
Source: Journal of Stroke and Cerebrovascular Diseases - June 2, 2019 Category: Neurology Authors: Takuya Kiyohara, Chie Abe, Mio Yokoi, Yusuke Sakaki, Yasuhiro Kumai Tags: Case Report Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Cardiac Imaging Within Emergency CT Angiography for Acute Stroke Can Detect Atrial Clots
This study was approved by the ethics committee of the medical faculty of the Ruhr University Bochum. FIGURE 1 Figure 1. Flow chart showing the selection of the study population. Results A total of 59 patients underwent emergency CCTA (Figure 2A) for suspected stroke, of which 44 received the final diagnosis ischemic stroke. There were 17 patients who had ischemic stroke or TIA and known or newly diagnosed atrial fibrillation (Table 1; mean age: 77.5 years, standard deviation: 8.4 years; 53% female). As hypothesized, intracardiac thrombi could be visualized: once in an artificially occluded left atrial appe...
Source: Frontiers in Neurology - April 9, 2019 Category: Neurology Source Type: research

Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study) Clinical Sciences
Conclusions—In addition to clinically apparent AF, other evidence of abnormal atrial substrate is associated with subsequent ischemic stroke. This finding is consistent with the hypothesis that thromboembolism from the left atrium may occur in the setting of several different manifestations of atrial disease.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Hooman Kamel, Traci M. Bartz, Mitchell S.V. Elkind, Peter M. Okin, Evan L. Thacker, Kristen K. Patton, Phyllis K. Stein, Christopher R. deFilippi, Rebecca F. Gottesman, Susan R. Heckbert, Richard A. Kronmal, Elsayed Z. Soliman, W.T. Longstreth Jr Tags: Arrhythmias, Cardiomyopathy, Echocardiography, Electrocardiology (ECG), Ischemic Stroke Original Contributions Source Type: research

Abnormal P-Wave Axis and Ischemic Stroke Clinical Sciences
Conclusions—aPWA is independently associated with ischemic stroke. This association seems to be stronger for cardioembolic strokes. Collectively, our findings suggest that alterations in atrial electric activation may predispose to cardiac thromboembolism independent of atrial fibrillation.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Ankit Maheshwari, Faye L. Norby, Elsayed Z. Soliman, Ryan J. Koene, Mary R. Rooney, Wesley T. O’Neal, Alvaro Alonso, Lin Y. Chen Tags: Arrhythmias, Electrophysiology, Ischemic Stroke Original Contributions Source Type: research

Electrocardiographic Left Atrial Abnormality and Risk of Stroke: Northern Manhattan Study Clinical Sciences
Conclusions— ECG-defined left atrial abnormality was associated with incident cryptogenic or cardioembolic stroke independently of the presence of AF, suggesting atrial thromboembolism may occur without recognized AF.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Kamel, H., Hunter, M., Moon, Y. P., Yaghi, S., Cheung, K., Di Tullio, M. R., Okin, P. M., Sacco, R. L., Soliman, E. Z., Elkind, M. S. V. Tags: Electrocardiology, Echocardiography, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

Electrocardiographic left atrial abnormality and stroke subtype in the atherosclerosis risk in communities study
ObjectiveThe aim of this study was to assess the relationship between abnormally increased P‐wave terminal force in lead V1, an electrocardiographic (ECG) marker of left atrial abnormality, and incident ischemic stroke subtypes. We hypothesized that associations would be stronger with nonlacunar stroke, given that we expected left atrial abnormality to reflect the risk of thromboembolism rather than in situ cerebral small‐vessel occlusion. MethodsOur cohort comprised 14,542 participants 45 to 64 years of age prospectively enrolled in the Atherosclerosis Risk in Communities study and free of clinically apparent atrial f...
Source: Annals of Neurology - August 31, 2015 Category: Neurology Authors: Hooman Kamel, Wesley T. O'Neal, Peter M. Okin, Laura R. Loehr, Alvaro Alonso, Elsayed Z. Soliman Tags: Research Article Source Type: research

Electrocardiographic Left Atrial Abnormality and Stroke Subtype in ARIC
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - July 15, 2015 Category: Neurology Authors: Hooman Kamel, Wesley T. O'Neal, Peter M. Okin, Laura R. Loehr, Alvaro Alonso, Elsayed Z. Soliman Tags: Research Article Source Type: research

Left atrial volumes and associated stroke subtypes
This study is a standardized review of 633 patients admitted to the stroke service of a tertiary care hospital following a standardized stroke investigation and management pathway. Stroke subtypes were characterized using the Causative Classification System, using the hospitals online radiologic archival system with CCS certified stroke investigators. Patients with two mechanisms were excluded. Results: Patients with cardioembolic stroke had a higher proportion of atrial fibrillation (p
Source: BMC Neurology - October 18, 2013 Category: Neurology Authors: Quratulain ShaikhBilal AhmedMaryam AhmedJamal MaharMasood AhmadAyesha AhmedFarzin MajeedFariha AliMaria KhanAyeesha Kamal Source Type: research

Thromboembolic risks of recombinant factor VIIa Use in warfarin-associated intracranial hemorrhage: a case¿control study
Background: Recombinant factor VIIa (rFVIIa) may be used for rapid hemostasis in life-threatening hemorrhage. In warfarin-associated intracerebral hemorrhage (wICH), FVIIa use is controversial and may carry significant thromboembolic risks. We compared incidence of baseline thromboembolic risk factors and thromboembolism rates in wICH patients treated with additional rFVIIa to those treated with standard therapy of fresh frozen plasma (FFP) and vitamin K alone. Methods: We identified 45 consecutive wICH patients treated with additional rFVIIa over 5-year period, and 34 consecutive wICH patients treated with standard therap...
Source: BMC Neurology - December 15, 2012 Category: Neurology Authors: Chou H-YCai XuemeiKonigsberg GBresette MHenderson VSorond AFeske K Source Type: research