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O-035 Risk factors for delayed deterioration after cerebral venous thrombosis: a model to identify patients for early aggressive endovascular therapy
Conclusion We found that decreased mental status, seizure activity, papilledema, number of involved sinuses, sodium level, and platelet level to be the most important factors in predicting deterioration after CVT. This group may represent a subset of patients in who early thrombectomy may be considered. Further prospective trials are needed to confirm this hypothesis. Abstract O-035 Figure 1Odds ratios of clinical deterioration for the predictors of the multivariable logistic regression model. To get the ratio of deterioration for catergory 1 versus 0, one needs to take the reciprocal Disclosures S. Bushnaq: None. T. ...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Bushnaq, S., Thacker, T., Abbas, M., Qeadan, F., Carlson, A. Tags: Oral Abstracts Source Type: research

Repeated Mechanical Thrombectomy in the Same Intracranial Artery Segment
We report a patient with an important scenario that may arise in the management of an acute ischemic stroke: the need for a repeated mechanical thrombectomy in the same intracranial artery segment. The patient had a history of atrial fibrillation and a mechanical mitral valve replacement. In her first stroke, she had an occlusion of the proximal segment of the right middle cerebral artery; 58 days later, she presented with an occlusion in the same segment of that cerebral artery. In both instances, the thrombus was extracted by a stent retriever with good clinical and radiographic results.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2017 Category: Neurology Authors: Herbert Tejada Meza, Maria Rosario Barrena Caballo, Santiago Guelbenzu Morte, Roberto Mart ínez García, Javier Marta Moreno Tags: Case Studies Source Type: research

Enhanced Detection of Edema in Malignant Anterior Circulation Stroke (EDEMA) Score Brief Report
Conclusions—The EDEMA score identifies patients at high risk for potentially lethal malignant edema. Although it requires external validation, this scale could help expedite triage decisions in this patient population.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Charlene Jennifer Ong, Jeffrey Gluckstein, Osvaldo Laurido-Soto, Yan Yan, Rajat Dhar, Jin-Moo Lee Tags: Clinical Studies, Cerebrovascular Disease/Stroke, Ischemic Stroke, Thrombosis Brief Reports Source Type: research

Rapidly improving neurological deficit of stroke; case series in Academic institute, KAUH, Jeddah (P4.283)
Conclusions:Rapidly improving patient represent a challenge to whether tPA should be given. However, the good outcome with thrombolytic therapy observed in our study, will hopfuly support the decision to treat.Study Supported by: nonDisclosure: Dr. khoja has nothing to disclose. Dr. Alshaer has nothing to disclose. Dr. al-Turkistani has nothing to disclose. Dr. Al-Mekhalfi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: khoja, a., Al-Shaer, D., al-Turkistani, a., Al-Mekhalfi, M. Tags: Thrombolysis and Acute Evaluation in Ischemic Stroke Source Type: research

Contrast induced encephalopathy mimicking reperfusion injury (P3.285)
Conclusions:Diagnostic or therapeutic angiography is frequently performed for acute ischemic or hemorrhagic stroke. Clinicians should be aware of contrast induced encephalopathy and consider it in cases of neurologic deterioration after angiography in order to initiate appropriate treatment and avoid unnecessary invasive tests.Disclosure: Dr. Bakradze has nothing to disclose. Dr. Pasquale has nothing to disclose. Dr. Kirchoff-Torres has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Bakradze, E., Pasquale, D., Kirchoff-Torres, K. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Spinal cord injury misdiagnosed as cerebral infarction and given thrombolytic therapy: A case report
【Background】Spinal Cord Injury Without Radiographic Abnormality (SCIWORA) covers a broad spectrum of neurological deficits, which can be confused with cerebral infarction when patients present with hemiparesis and a history of minor injury.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Jie Yang, Jing Hang, Junshan Zhou, Yingdong Zhang Source Type: research

Simple prediction model for unfavorable outcome in ischemic stroke after intravenous thrombolytic therapy
Conclusion An NIHSS> 12 on arrival, presence of HAS and age> 70 years were predictors of unfavorable outcome at three months in patients with acute ischemic stroke treated with IVT.RESUMO Objetivo Desenvolver um modelo para predizer desfecho desfavor ável em pacientes com acidente vascular cerebral isquêmico (AVCi) agudo tratados com terapia trombolítica intravenosa (TTI), baseado em variáveis simples presentes à admissão. Métodos Análise retrospectiva de casos de AVCi tratados com TTI em um hospital no Rio de Janeiro. Variáveis clín icas e radiográficas foram selecionadas para análise. Foi utilizada regr...
Source: Arquivos de Neuro-Psiquiatria - December 15, 2016 Category: Neurology Source Type: research

P08.46 Rechallenge with bevacizumab in a long-term survivor with glioblastoma
The prognosis of patients with glioblastoma multiforme (GBM, WHO grade IV), the most common primary brain tumor in adults, is generally poor with median survival of less than one year in untreated patients and approximately 15 months following standard of care therapy. However, 10 % survival at 5 years was observed in a randomized phase III study. At GBM recurrence, the addition of bevacizumab (BEV), a humanized monoclonal antibody against circulating vascular endothelial growth factor (VEGF), resulted in a 3–4 month prolongation of progression-free survival (PFS) without improving overall survival (OS...
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Koeppen, S., Hense, J. Tags: P08 Glioblastom and Anaplastic gliomas Source Type: research

To Treat or Not to Treat M2 Occlusions? The Question (and Answer) From a Single Institution
CONCLUSION: The results of our single-institution experience suggest that endovascular therapy for M2 occlusions is safe and effective. Additional evaluation with randomized, controlled studies is warranted. ABBREVIATIONS: ADAPT, direct aspiration first-pass technique ECASS, European-Australasian Cooperative Acute Stroke Study ICH, intracranial hemorrhage IMS, Interventional Management of Stroke MERCI, Mechanical Embolus Removal in Cerebral Ischemia mRS, modified Rankin Scale NIHSS, National Institutes of Health Stroke Scale PROACT, Prolyse in Acute Cerebral Thromboembolism TICI, Thrombolysis in Cerebral Infarctio...
Source: Neurosurgery - September 1, 2016 Category: Neurosurgery Tags: Research-Human-Clinical Studies Source Type: research

E-067 Endovascular Approach in the Repair of the Middle Cerebral Artery Aneurysm Including Those with Wide Neck and Complex in Morphology-A Case Series
ConclusionsEndovascular repair of the MCA aneurysm inclosing those with wide neck and complex are not only safe and feasible, but associated with high long-term functional outcome. Therefore, endovascular options must be offered to patients prior to surgical clipping of a MCA aneurysm. Further study may be warranted.DisclosuresY. Lodi: None. V. Reddy: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Lodi, Y., Reddy, V. Tags: Electronic poster abstracts Source Type: research

P-001 Permanent Implantation of the Solitaire Device as a Bailout Technique for Large Vessel Intracranial Occlusions
ConclusionWith the recent over-whelming evidence demonstrating the effectiveness endovascular therapy in acute ischemic stroke, the expansion of stroke therapy requires that a variety of techniques be available to the operators. Permanent implantation of the Solitaire stent achieves adequate distal flow and good clinical outcomes in the setting of AIS. This case series suggests this technique provides a safe alternative for difficult cases refractory to other revascularization techniques.Key Wordsstroke, revascularization, stentDisclosuresJ. Houde: None. E. Barber: None. M. Kelly: 2; C; Medtronic. 4; C; Blockade. 6; C; Pen...
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Houde, J., Barber, E., Kelly, M., Peeling, L. Tags: Oral poster abstracts Source Type: research

P-010 Association of Clot Burden Score with Radiographic and Clinical Outcomes Following Solitaire Stent Retriever Thrombectomy: Analysis of the SWIFT PRIME Trial
ConclusionsThe combination of IV thrombolysis and stent retriever thrombectomy with the Solitaire device is highly effective in achieving successful recanalization and a good clinical outcome throughout the entire range of CBS values.DisclosuresM. Mokin: None. E. Levy: 4; C; Intratech Medical Ltd., Blockade Medical LLC, Medina Medical. 6; C; Covidien (Medtronic), Abbott, Intratech Medical and Blockade Medical. A. Siddqui: 2; C; Codman & Shurtleff, Inc., Concentric Medical, ev3/Covidien Vascular Therapies, GuidePoint Global Consulting, Penumbra, Stryker, Pulsar Vascular, MicroVention, Lazarus Effect, Blockade Medical. 3...
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Mokin, M., Levy, E., Siddqui, A., Goyal, M., Nogueira, R., Yavagal, D., Pereira, V., Saver, J. Tags: Oral poster abstracts Source Type: research

Vascular Territories of Ischemic Stroke in Associated Takotsubo Cardiomyopathy (P1.221)
Conclusions: TC is a reversible cardiomyopathy that has an association with ischemic stroke. This condition can notably be both the cause and effect of stroke. Ischemic stroke of the left middle cerebral artery appears to be the most prevalent. In female patients suffering from middle cerebral artery distribution ischemic stroke and cardiac dysfunction, TC should be considered.Disclosure: Dr. Zia has nothing to disclose. Dr. Silliman has received research support from Genzyme Corporation, Biogen Idec, and Novartis.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Zia, A., Silliman, S. Tags: Cardiac Mechanisms and Complications of Stroke Source Type: research

Susceptibility-weighted Imaging in Neurovascular Disease
Abstract: Susceptibility-weighted imaging (SWI) has become an important imaging sequence in the evaluation of patients with neurovascular disease. In this review, we provide a general overview of the physics of SWI and describe how image contrast is produced with this technique. We provide a general approach and differential diagnosis for 2 commonly encountered radiographic patterns seen with SWI in neurovascular disease. Finally, we discuss specific neurovascular applications of SWI, including its application in acute stroke, vascular malformations, venous thrombosis, and evaluation of cerebral microbleeds.
Source: Topics in Magnetic Resonance Imaging - April 1, 2016 Category: Radiology Tags: Review Articles Source Type: research

Pediatric Cortical Vein Thrombosis: Frequency and Association With Venous Infarction Brief Reports
Conclusions— In our cohort, CVT was significantly associated with seizures at presentation, hemorrhage and restricted diffusion on acute imaging, as well as neurological disability and venous infarction at follow-up. Involvement of cortical veins in cerebral sinovenous thrombosis is associated with an increased risk of infarction and adverse outcome in children.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Ritchey, Z., Hollatz, A. L., Weitzenkamp, D., Fenton, L. Z., Maxwell, E. C., Bernard, T. J., Stence, N. V. Tags: Pediatrics, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

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