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Specialty: Neuroscience
Condition: Thrombosis

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Total 164 results found since Jan 2013.

Unfavorable Outcome of Thrombolysis in Chinese Patients with Cardioembolic Stroke: a Prospective Cohort Study.
CONCLUSIONS: Patients with cardioembolic stroke had more SICH after thrombolysis, and worse clinical outcome at 3-month follow-up compared with those with LAA. This emphasizes the importance of preventing cardioembolism. PMID: 26096605 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - June 20, 2015 Category: Neuroscience Authors: Wang XG, Zhang LQ, Liao XL, Pan YS, Shi YZ, Wang CJ, Wang YL, Liu LP, Zhao XQ, Wang YJ, Li D, Wang CX, Thrombolysis Implementation and Monitoring of acute ischemic Stroke in China (TIMS-China) Investigators Tags: CNS Neurosci Ther Source Type: research

Targeting neutrophils in ischemic stroke: translational insights from experimental studies
Frank R Sharp
Source: Journal of Cerebral Blood Flow and Metabolism - May 29, 2015 Category: Neuroscience Authors: Glen C JicklingDaZhi LiuBradley P AnderBoryana StamovaXinhua ZhanFrank R Sharp Tags: atherosclerosis cerebral ischemia immune system neutrophil stroke thrombus Source Type: research

Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke
Neurochem Res. 2022 Jun 8. doi: 10.1007/s11064-022-03628-7. Online ahead of print.ABSTRACTStroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repos...
Source: Neurochemical Research - June 8, 2022 Category: Neuroscience Authors: Tayebeh Noori Samira Shirooie Antoni Sureda Eduardo Sobarzo-Sanchez Ahmad Reza Dehpour Marianela Sald ías Esra K üpeli Akkol Source Type: research

Stroke biomarkers in clinical practice: A critical appraisal
Publication date: Available online 11 January 2017 Source:Neurochemistry International Author(s): Geelyn J.L. Ng, Amy M.L. Quek, Christine Cheung, Thiruma V. Arumugam, Raymond C.S. Seet Biomarkers provide critical mechanistic insights to key biologic processes that occur during cerebral ischemia which, when carefully applied, can improve clinical decision-making in acute stroke management. The translation of a blood-based biomarker in ischemic stroke to clinical practice is challenging, in part, due to the complexity of ischemic stroke pathogenesis and the presence of a blood-brain barrier that restricts the release of br...
Source: Neurochemistry International - January 11, 2017 Category: Neuroscience Source Type: research

Effect of Sex and Age Interactions on Functional Outcome after Stroke.
Abstract Stroke is one of the leading causes of death and disability worldwide. Experimental and clinical studies showed that sex and age play an important role in deciding the outcome after stroke. At younger ages, males were shown to have a higher risk for stroke than females. However, this trend reverses in older ages particularly when females reach menopause. Many preclinical studies indicate that steroid hormones modulate the age-dependent differential stroke outcome. In addition, patterns of cell death pathways activated following cerebral ischemia are distinct between males and females, but independent of s...
Source: CNS Neuroscience and Therapeutics - November 18, 2014 Category: Neuroscience Authors: Kim T, Vemuganti R Tags: CNS Neurosci Ther Source Type: research

A Successful Quality Improvement Project for Detection and Management of Acute Stroke in Hospitalized Patients
CONCLUSION: The new IHS protocol has led to a marked increase in cases identified, rapid evaluation, and high utilization rate of acute stroke therapies.
Source: Journal of Neuroscience Nursing - July 30, 2020 Category: Neuroscience Tags: Clinical Nursing Focus Source Type: research

National data on stroke outcomes in Thailand
In conclusion, the prevalence and outcomes of stroke in Thailand were comparable with other countries. The era of thrombolytic therapy has just begun in Thailand.
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

Rosiglitazone ameliorates tissue plasminogen activator-induced brain hemorrhage after stroke.
CONCLUSIONS: RSG treatment protects against BBB damage and ameliorates HT in delayed tPA-treated stroke mice by activating PPAR-γ and favoring microglial polarization toward anti-inflammatory phenotype. PMID: 31756041 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - November 21, 2019 Category: Neuroscience Authors: Li Y, Zhu ZY, Lu BW, Huang TT, Zhang YM, Zhou NY, Xuan W, Chen ZA, Wen DX, Yu WF, Li PY Tags: CNS Neurosci Ther Source Type: research

Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke
In conclusion, ML351 and tPA combination therapy is beneficial in ameliorating HT afte r ischemic stroke. This protective effect is probably because of 12/15‐LOX inhibition and suppression of JNK‐mediated microglia/macrophage activation.
Source: Journal of Neurochemistry - February 5, 2021 Category: Neuroscience Authors: Guangsen Cheng, Wei Zhao, Yongjie Xin, Guomin Huang, Yongkang Liu, Zhongliang Li, Meixiao Zhan, Yong Li, Ligong Lu, Klaus Leyen, Yu Liu Tags: ORIGINAL ARTICLE Source Type: research

Factors that Influence Door-to-Needle Administration for Acute Stroke Patients in the Emergency Department
CONCLUSION: Although many factors can influence door-to-needle times in the ED, we did not find National Institutes of Health Stroke Scale score on arrival and time of day to be significant factors. Patients arriving to the ED by personal vehicle will have a significant delay in IV alteplase administration, therefore emphasizing the importance of using emergency medical services. Perhaps more importantly, collaborative efforts including the addition of a specialized stroke nurse significantly decreased time to IV alteplase administration for AIS patients. With this dedicated role, accelerated triage and more effective mana...
Source: Journal of Neuroscience Nursing - May 18, 2021 Category: Neuroscience Tags: Articles Source Type: research

Low dose tPA plus annexin A2 combination attenuates tPA delayed treatment- associated hemorrhage and improves recovery in rat embolic focal stroke
In conclusion, compared to conventional tPA alone, when treated at delayed 4-hour after stroke, the combination of low-dose tPA plus rA2 therapy provides a safer profile by lowering risk of ICH transformation and improves neurological function recovery after stroke.
Source: Neuroscience Letters - July 10, 2015 Category: Neuroscience Source Type: research

Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation
In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome (P < 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were: heart failure (P = 0.045); high systolic pressure (P = 0.039); high blood glucose (P = 0.030); and a high National Institutes of Health Stroke Scale (NIHSS) score (P < 0.001). Moreover, high systolic pressur...
Source: Neuroscience Bulletin - March 7, 2016 Category: Neuroscience Source Type: research