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P151/175 Direct aspiration with EMBOVAC - first clinical experience and clot composition (results the "PERFECT study)
ConclusionThis is the first clinical evaluation of EMBOVAC. Direct aspiration with EMBOVAC as first line therapy resulted in high rates of reperfusion and favorable clinical outcomes. Clot composition analysis can aid in better understanding of the stroke etiology and means for effective clot removal.Disclosure of InterestAcandis (OJ, CL, JF); Microvention (GM, CC, JF); Stryker (GM, CC, JF); Medtronic (GM, CC, JF); Surge2surgery (BG); MIVI (CC); Phenox (CL, JF); Penumbra (CL, JF); GSK (AS); German Ministry of Science & Education and Economy & Innovation, EU, Hamburgische Investitions-/Förderbank, Philips, B...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Lobotesis, K., Jansen, O., Marnat, G., Gory, B., Nordmeyer, H., Eckert, B., Alessandro, P., Cognard, C., Loehr, C., Bracco, S., Schaefer, A., Macera, A., Fiehler, J., Doyle, K., Piano, M. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

P83 The relationship of functional outcome after mechanical thrombectomy and serum glucose is partially mediated by edema formation
ConclusionEdema formation explains 15% of the total adverse effects of high blood glucose levels. Major pathways might include other direct effects of high blood glucose, such as altered vessel wall and thrombus characteristics and higher thrombogenicity of the cerebral blood flow.ReferencesThorén, M., et al. "Predictors for Cerebral Edema in Acute Ischemic Stroke Treated with Intravenous Thrombolysis." Stroke 2017;48(9): 2464–2471. Do you have any conflict of interest to declare?: YesConflict of Interest StatementHelge Kniep is a consultant for Eppdata.Jens Fiehler received research support from: German Minis...
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Kniep, H., Meyer, L., Bechstein, M., Hanning, U., Fiehler, J., Broocks, G. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

Effects of Thrombin on the Neurovascular Unit in Cerebral Ischemia.
Abstract Cerebral ischemia is a cerebrovascular disease with high morbidity and mortality that poses a significant burden on society and the economy. About 60% of cerebral ischemia is caused by thrombus, and the formation of thrombus proceeds from insoluble fibrin, following its transformation from liquid fibrinogen. In thrombus-induced ischemia, increased permeability of the blood-brain barrier (BBB), followed by the extravasation of blood components into the brain results in an altered brain microenvironment. Changes in the brain microenvironment affect brain function and the neurovascular unit (NVU), the workin...
Source: Cellular and Molecular Neurobiology - January 3, 2021 Category: Cytology Authors: Cao H, Seto SW, Bhuyan DJ, Chan HH, Song W Tags: Cell Mol Neurobiol Source Type: research

Snake venom three-finger toxins and their potential in drug development targeting cardiovascular diseases.
Abstract Cardiovascular diseases such as coronary and peripheral artery diseases, venous thrombosis, stroke, hypertension, and heart failure are enormous burden to health and economy globally. Snake venoms have been the sources of discovery of successful therapeutics targeting cardiovascular diseases. For example, the first-in-class angiotensin-converting enzyme inhibitor captopril was designed largely based on bradykinin-potentiating peptides from Bothrops jararaca venom. In the recent years, sensitive and high throughput approaches drive discovery and cataloging of new snake venom toxins. As one of the largest c...
Source: Biochemical Pharmacology - June 20, 2020 Category: Drugs & Pharmacology Authors: Manjunatha Kini R, Yeow Koh C Tags: Biochem Pharmacol Source Type: research

Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association.
diovascular and Stroke Nursing; and Stroke Council Abstract Cardio-obstetrics has emerged as an important multidisciplinary field that requires a team approach to the management of cardiovascular disease during pregnancy. Cardiac conditions during pregnancy include hypertensive disorders, hypercholesterolemia, myocardial infarction, cardiomyopathies, arrhythmias, valvular disease, thromboembolic disease, aortic disease, and cerebrovascular diseases. Cardiovascular disease is the primary cause of pregnancy-related mortality in the United States. Advancing maternal age and preexisting comorbid conditions have contri...
Source: Circulation - May 3, 2020 Category: Cardiology Authors: Mehta LS, Warnes CA, Bradley E, Burton T, Economy K, Mehran R, Safdar B, Sharma G, Wood M, Valente AM, Santos Volgman A, American Heart Association Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Ca Tags: Circulation Source Type: research

A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind. Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the ...
Source: Frontiers in Human Neuroscience - April 25, 2019 Category: Neuroscience Source Type: research

Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients wi...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Economy Class Syndrome, patent foramen ovale and stroke
Whether or not air travel in a patient with patent foramen ovale (PFO) is a risk factor for cerebral embolism is unresolved. This is illustrated by a recent case report of the Massachusetts General Hospital in the New England Journal of Medicine of deep venous thrombosis and stroke associated with air travel. The discussant concluded that because of the relatively short flight “it seems unlikely that air travel was a major risk factor” 1. This may well be true for deep venous thrombosis per se, the risk of which has been shown to increase with duration of the flight 2.
Source: The American Journal of Cardiology - August 1, 2016 Category: Cardiology Authors: Franz H. Messerli, Stefano F. Rimoldi, Urs Scherrer Source Type: research

Rheumatic Valve Disease and Stroke. A Public Health Problem in Countries in Way of Develop (P1.288)
Conclusions: In our population RVD with or without AF is the main cause of cerebral ischemia, just preceded by thrombosis of large arteries, affecting young and productive people, which severely impacts the economy of families and country that walking towards development. Mexico along with other emerging countries needs to implement public health programs in the early diagnosis and treatment of this health problem.Disclosure: Dr. Mendez-Dominguez has nothing to disclose. Dr. Arias-Fernandez has nothing to disclose. Dr. Aguirre-Delfin has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Mendez-Dominguez, A., Arias-Fernandez, J., Aguirre-Delfin, M. Tags: Global Health: Infectious Disease, Capacity Building, and Other Source Type: research

Prevention and follow-up in thromboembolic ischemic stroke: Do we need to think out of the box?
Stroke is one of the most debilitating thrombotic diseases, and world-wide it is estimated that by, 2030 23 million people will be affected. Except for the impact on the individual families, the world economy is also affected adversely. Although the medical treatment and knowledge of stroke are both increasing and well-researched, we still do not see a light in the tunnel. Currently various diagnostic tests are employed to determine the specific type of ischemic stroke as classified by the TOAST criteria.
Source: Thrombosis Research - November 4, 2015 Category: Hematology Authors: Albe C. Swanepoel, Etheresia Pretorius Tags: Review Article Source Type: research