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Condition: Thrombosis
Infectious Disease: Pandemics
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Total 181 results found since Jan 2013.
Neurological consequences of COVID-19
Pharmacol Rep. 2022 Sep 30. doi: 10.1007/s43440-022-00424-6. Online ahead of print.ABSTRACTIn December 2019, cases of pneumonia caused by infection with the previously unknown severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leading to coronavirus disease 2019 (COVID-19), were identified. Typical manifestations of COVID-19 are fever, cough, fatigue and dyspnoea. Initially, it was thought that the mechanism of action of SARS-CoV-2 was only associated with respiratory tract invasion, but it was later revealed that the infection might involve many other organs and systems, including the central and peripheral ner...
Source: Pharmacological Reports - September 30, 2022 Category: Drugs & Pharmacology Authors: Waldemar Brola Maciej Wilski Source Type: research
An acute lower limb ischemia revealing a covid-19 infection: A case report
CONCLUSION: The coagulopathy responsible for venous and arterial thrombosis is a well-established complication of COVID-19. Arterial thromboembolic complications can be either stroke, acute coronary syndrome or peripheral acute ischemia. Therefore, patients with covid19 should be monitored more closely for thromboembolic complications.PMID:35999833 | PMC:PMC9389520 | DOI:10.1016/j.amsu.2022.104445
Source: Annals of Medicine - August 24, 2022 Category: Internal Medicine Authors: Rim El Mesnaoui Soumaila Nikiema Desire Massimbo Abbes El Mesnaoui Source Type: research
Treatments in Ischemic Stroke: Current and Future
Background and Aim: Despite progress made over the last 30 years, stroke is still a leading cause of disability and mortality; likewise, its burden is expected to increase over the next decades, due to population growth and aging. The development of drugs with better safety-efficacy profiles as well as strategies able to improve ischemic stroke management from the pre-hospital setting is needed.Summary: The pathophysiology of ischemic stroke involves multiple pathways resulting in cerebral artery obstruction and brain tissue ischemia. To date, the only approved drug for acute ischemic stroke is intravenous thrombolytic alt...
Source: European Neurology - August 2, 2022 Category: Neurology Source Type: research
Acute Occupational and Physical Therapy for COVID-19 Patients: A Retrospective Cohort Study
In March 2020, the World Health Organization (WHO) declared the novel coronavirus strain SARS-CoV2 (the virus causing COVID-19) a global pandemic.24 The severity of illness in those exhibiting symptoms ranges from mild (cough, shortness of breath, fatigue) to severe (acute respiratory distress syndrome (ARDS), thrombosis, stroke, and death).4,11 Patients have also acquired acute polyradiculoneuritis (Guillain Barre syndrome) at a disproportionately high rate, contributing to functional limitations that require specialized and intensive rehabilitation.
Source: Archives of Physical Medicine and Rehabilitation - July 31, 2022 Category: Rehabilitation Authors: Katie Coakley, Laura Friedman, Kaitlyn McLoughlin, Amy Wozniak, Paul Hutchison Tags: Original Research Source Type: research
Impact of the COVID-19 pandemic on England's national prescriptions of oral vitamin K antagonist (VKA) and direct-acting oral anticoagulants (DOACs): An interrupted time series analysis (January 2019 - February 2021)
Conclusion: The overall oral anticoagulants use in this period was lower than expected, indicating a medical needs gap, possibly due to adherence issues. The potential clinical and logistical consequences warrant further study to identify contributing factors and mitigate avoidable risks.PMID:35582854 | DOI:10.1080/03007995.2022.2078100
Source: Current Medical Research and Opinion - May 18, 2022 Category: Research Authors: Sajidah Alkhameys Ravina Barrett Source Type: research
Preface: COVID-19 Pandemic: Direct and Indirect Cardiovascular Effects
The COVID-19 pandemic has had a dramatic impact on the care of patients with cardiovascular disease throughout the world. COVID-19 has a myriad of direct effects on the myocardium, vasculature and coagulation cascade, related to the pro-inflammatory and prothrombotic effects of the virus, leading to an increase risk of myocardial infarction, stroke, deep venous thrombosis (DVT), and pulmonary emboli within the first 2-4 weeks of contracting the disease. Patients with pre-existent cardiovascular disease and/or cardiovascular risk factors such as hypertension and diabetes are particularly susceptible to suffer complications ...
Source: Cardiology Clinics - May 11, 2022 Category: Cardiology Authors: Timothy D. Henry, Santiago Garcia Source Type: research
COVID-19 Pandemic: Direct and Indirect Cardiovascular Effects
The COVID-19 pandemic has had a dramatic impact on the care of patients with cardiovascular disease throughout the world. COVID-19 has a myriad of direct effects on the myocardium, vasculature, and coagulation cascade, related to the proinflammatory and prothrombotic effects of the virus, leading to an increased risk of myocardial infarction, stroke, deep venous thrombosis, and pulmonary emboli within the first 2 to 4 weeks of contracting the disease. Patients with preexistent cardiovascular disease and/or cardiovascular risk factors, such as hypertension and diabetes, are particularly susceptible to suffer complications f...
Source: Cardiology Clinics - May 11, 2022 Category: Cardiology Authors: Timothy D. Henry, Santiago Garcia Tags: Preface Source Type: research
Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia
In conclusion, insufficient resolution of NETs, e.g. by endogenous DNases or protection of NETs against degradation by embedded factors like the antimicrobial peptide LL-37 might thus be an important factor in the pathology of VITT besides increased NET-formation. On the basis of these findings, we discuss the potential implications of the mechanisms of disturbed NETs-degradation for diagnostic and therapeutic approaches in VITT-related thrombogenesis, other auto-immune disorders and beyond.
Source: Frontiers in Immunology - May 10, 2022 Category: Allergy & Immunology Source Type: research
The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era: A Single-Center Retrospective Cohort Study
CONCLUSION: Since there was a more dismal outcome in COVID-19 associated CVST, a high index of suspicion for CVST among COVID-19 positive is recommended.PMID:35523051 | PMC:PMC8947940 | DOI:10.1016/j.jstrokecerebrovasdis.2022.106468
Source: Atherosclerosis - May 6, 2022 Category: Cardiology Authors: Maryam Vasaghi Gharamaleki Maryam Habibagahi Etrat Hooshmandi Reza Tabrizi Shahram Arsang-Jang Zohreh Barzegar Nima Fadakar Vahid Reza Ostovan Abbas Rahimi-Jaberi Nahid Ashjazadeh Peyman Petramfar Maryam Poursadeghfard Sadegh Izadi Masoumeh Nazeri Hanieh Source Type: research
Large Vessel Occlusions By Free Floating Thrombi in Strokes During the COVID-19 pandemic- A Single Center Observational Study
Conclusions: This study highlights the presence of FFT causing LVO as a new stroke subtype during the COVID-19 pandemic. With renewed and steeper spike in COVID-19 cases, especially new variants, the resurgence of this stroke subtype needs to be actively explored early in the course of illness to reduce morbidity and mortality.
Source: Neurology India - May 3, 2022 Category: Neurology Authors: Samhita Panda Sarbesh Tiwari Jaya Pamnani Monalisa Vegda Apoorv Patel Sanjiv Sharma Saksham Jain Pratik Patel Deepika Saroha Pushpinder Khera Naresh Midha Mayank Garg Vijaya Lakshmi Nag Source Type: research
Changes in incidence rates of outcomes of interest in vaccine safety studies during the COVID-19 pandemic
CONCLUSION: Rates of some clinical outcomes during the pandemic changed and should not be used as historical background rates in vaccine safety studies. Inclusion of telehealth visits should be considered for vaccine studies involving Bell's palsy, ITP, and narcolepsy/cataplexy.PMID:35465977 | DOI:10.1016/j.vaccine.2022.04.037
Source: Vaccine - April 25, 2022 Category: Allergy & Immunology Authors: Stanley Xu Vennis Hong Lina S Sy Sungching C Glenn Denison S Ryan Kerresa L Morrissette Jennifer C Nelson Simon J Hambidge Bradley Crane Ousseny Zerbo Malini B DeSilva Jason M Glanz James G Donahue Elizabeth Liles Jonathan Duffy Lei Qian Source Type: research
