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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Thrombosis
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Total 415 results found since Jan 2013.
Low value of inherited thrombophilia testing among patients with stroke or transient ischemic attack: A three-year retrospective study
Inherited thrombophilia testing in the acute inpatient setting is controversial and expensive, and rarely changes clinical management. We evaluated ordering patterns and results of inpatient inherited thrombophilia testing for patients who presented with an isolated acute ischemic stroke or transient ischemic attack (TIA) without concurrent venous thromboembolism.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Shyam Majmundar, Sameep Thapa, Elan S. Miller, Rodney Bell, Robin Dharia, Diana Tzeng, Shaista Alam, Ruben Rhoades Source Type: research
Risk of recurrent ischemic stroke in patients with patent foramen ovale: The role of D-dimer
Paradoxical embolism under elevated thromboembolic conditions is known to be the primary mechanism of patent foramen ovale (PFO)-related stroke. We hypothesized that higher levels of D-dimer, a marker of thromboembolism, could increase the risk of stroke recurrence in patients with PFO.
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2023 Category: Neurology Authors: Seongho Park, Boseong Kwon, Jin Kyung Oh, Jae-Kwan Song, Ji Sung Lee, Sun U. Kwon Source Type: research
Factors influencing real-life use of direct oral anticoagulants in patients with cerebral sinus and venous thrombosis
Cerebral sinus and venous thrombosis (CSVT) is a rare subtype of stroke caused by thrombosis of the dural sinuses and cerebral veins which comprises 0.5 –1% of all strokes1,2. The annual incidence ranges from 0.22 to 1.57 per 100,000, most often affecting young adults with a median age of 35 years3-5. Among CSVT patients, the female-to-male ratio is 3:1 and women are significantly younger compared to men6. This is largely due to the increased risk of CSVT associated with oral contraceptives, pregnancy and the puerperium3,7,8.
Source: Journal of Stroke and Cerebrovascular Diseases - July 10, 2023 Category: Neurology Authors: Naaem Simaan, Jeremy Molad, Asaf Honig, Andrei Filioglo, Shlomi Peretz, Fadi Shbat, Tarek Mansor, Waleed Abu-shaheen, Ronen R. Leker Source Type: research
Risk of intracranial hemorrhage with direct oral anticoagulation versus low molecular weight heparin in the treatment of brain tumor-associated venous thromboembolism: A meta-analysis
Direct oral anticoagulants (DOACs) are effective in treating cancer-related thrombosis and are superior to low molecular weight heparin (LMWH) in terms of efficacy. The effects of DOACs or LMWH on intracranial hemorrhage (ICH) remain uncertain in individuals with brain tumors. We conducted a meta-analysis to compare the frequency of ICH in individuals with brain tumors treated with DOACs or LMWH.
Source: Journal of Stroke and Cerebrovascular Diseases - July 4, 2023 Category: Neurology Authors: Jun Yang, Zesong He, Meihua Li, Tao Hong, Taohui Ouyang Source Type: research
Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2
Ischemic stroke is a frequently occurring cerebrovascular disease (CVD) linked to high mortality, disability, and incidence rates, and the second factor causing global mortality41,3. There are two common sources of embolism in ischamic strokes: large artery atherosclerosis and small artery atherosclerosis. Ischemic stroke can be treated clinically with thrombolytic therapy4. Although ischemic stroke is treatable, post-cerebral ischemia blood reperfusion frequently induces inflammation, oxidative stress (OS) or additional unfavorable events that may exacerbate brain injury20,24.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2023 Category: Neurology Authors: Yingju Wang, Hongping Chen, Xuehui Fan, Chen Xu, Meng Li, Hongxue Sun, Jihe Song, Feihong Jia, Wan Wei, Fangchao Jiang, Guozhong Li, Di Zhong Source Type: research
Blood group and ischemic stroke, myocardial infarction, and peripheral vascular disease: A meta-analysis of over 145,000 cases and 2,000,000 controls
The ABO blood groups have been associated with the pathophysiology of cardiovascular diseases through an influence on two important blood clotting proteins, von Willebrand factor (vWF) and factor FVIII levels (FVIII).1,2 These proteins circulate in the plasma as a complex and are vital in normal haemostasis.1 The highest levels of FVIII and VWF are seen in non-O blood groups. Studies suggest a relationship between non-O blood groups and an increased risk of venous thromboembolism and other thrombotic episodes.
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2023 Category: Neurology Authors: Zornitsa Lilova, Faiza Hassan, Malaika Riaz, Joshua Ironside, Gie Ken-Dror, Thang Han, Pankaj Sharma Source Type: research
An elderly case with late carotid stent thrombosis: possible role of antiphospholipid antibodies
The case study speculates that the antiphospholipid antibodies acquired during the follow-up period of carotid artery stenting may cause late stent thrombosis that is resistant to direct oral anticoagulants. A 73-year-old man was hospitalized with complaints of weakness in the right lower extremity. The patient had undergone carotid artery stenting for symptomatic stenosis of the left internal carotid artery 6 years prior and had received antiplatelet therapy with clopidogrel 75 mg/day. As the patient had developed atrial fibrillation without stent stenosis at the age of 70 years, anticoagulation therapy with rivaroxaban...
Source: Journal of Stroke and Cerebrovascular Diseases - May 26, 2023 Category: Neurology Authors: Shinji Kitsuki, Kenji Fukuda, Tomonaga Matsushita, Yoshihisa Fukushima, Tetsuro Ago, Takanari Kitazono Tags: Case Report Source Type: research
Letter to the Editor Regarding ‘A neonatal case of cerebral venous sinus thrombosis with intrauterine onset after COVID19 infection during pregnancy: cause or coincidence?’
We read with interest the article by Ozdil et al. about a three day-old female neonate who was diagnosed with venous sinus thrombosis (VST) which was complicated by a subacute, partial ischemic stroke in the territory of the right middle cerebral artery.1 The age of the stroke was estimated at 14-28 days before birth.1 Because the mother suffered a mild coronvirus disease-19 (COVID-19) infection during the initial weeks of the third trimester (gestational weeks 27-30), VST in the fetus was causally related to the severe, acute respiratory syndrome-coronavirus type-2 (SARS-CoV-2) infection of the mother.
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2023 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
Time to ct scan imaging after symptom onset among ischeamic stroke patients presenting to a quaternary hospital in ghana
This study sought to determine the time of onset of symptoms to the time a CT imaging was done among patients presenting with acute stroke at the Korle-Bu Teaching Hospital.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2023 Category: Neurology Authors: F. Duodu, D. Brodie Mends, B. Agbinko-Djobalar, P. Pekyi-Boateng, M. Amerwornu, P Adjei, A Akpalu, K Nkromah Source Type: research
In Reply to the Letter to the Editor Regarding "A neonatal case of cerebral venous sinus thrombosis with intrauterine onset after COVID-19 infection during pregnancy: Cause or coincidence?"
We are grateful to Josef Finsterer for his comments on our recent case regarding the possible association of maternal COVID-19 infection during pregnancy with a neonatal case of intrauterine cerebral sinus venous thrombosis (CSVT). In the letter to editor, he had raised several arguments against a causal relationship, however our case report focused on the plausability of maternal COVID-19 infection as a triggering factor for in utero onset of CVST.
Source: Journal of Stroke and Cerebrovascular Diseases - March 6, 2023 Category: Neurology Authors: Dr Mine Ozdil, Dr İpek Dokurel Cetin Tags: Letter to the Editor Source Type: research
Extra-criteria antiphospholipid antibodies in patients with small vessel brain lesions and clinical manifestations associated with antiphospholipid syndrome
Antiphospholipid syndrome (APS) – as included in the updated APS classification criteria – is characterized by circulating antibodies (Abs) directed against phospholipid-binding proteins or their complex with phospholipids (aPL) and clinical manifestations of thrombosis or gestational morbidity.1 These criteria are very specif ic to ensure homogeneity for some purposes, such as clinical assays, yet they are not very sensitive for APS diagnosis.2 Due to this lack of sensitivity, clinicians must be aware of some entities – distinct from thrombosis fetal losses, or eclampsia – that are not included in the classificati...
Source: Journal of Stroke and Cerebrovascular Diseases - February 24, 2023 Category: Neurology Authors: Miguel Ángel Estévez, Nallibe Lanio, Águeda Molina, Maria Reyes Jiménez-León, María José Picado, Eva Esteban, Sonia Sánchez, Lucio Pallarés, Maria Rosa Julià Source Type: research
Genetic variants in the promoters of let-7 are associated with the risk and age at onset of ischemic stroke: A case control study
Stroke is China's main cause of mortality and years of life lost. With the aging population and increasing urbanization, stroke incidence has risen in China.1 Ischemic stroke (IS) is a multifactorial and multigenic disease that develops when blood supply to a specific part of the brain is disrupted or diminished, generally due to a thrombus. Although there are advancements in recanalization therapy, treatment options for stroke are still limited.2 Identifying genetic variants related to the onset risk of IS could contribute to understanding its pathogenesis and further developing innovative strategies for managing and prev...
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2023 Category: Neurology Authors: Yuye Wang, Luying Qiu, Wenjuan Jiang, Meilin Chen, Zhiyi He, Yanzhe Wang, Shumin Deng Source Type: research
Early high-dose intravenous immunoglobulin for refractory heparin-induced thrombocytopenia with stroke: Two case reports
Heparin-induced thrombocytopenia (HIT) is a drug reaction caused by anti-platelet factor 4 (PF4)/heparin antibodies of the IgG class that activate through Fc γ receptors on platelets and monocytes. They consume platelets and increase thrombin generation.1 HIT occurs 5 to 14 days after the start of heparinization.2 Management of HIT involves discontinuing heparin and switching to an alternative anticoagulant to prevent thrombosis and normalize platelet l evels.3–5 Autoimmune HIT (aHIT), which maintains marked heparin-independent platelet activation even after discontinuing heparin, has recently attracted attention.
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2023 Category: Neurology Authors: Naoki Makita, Tomoyuki Ohara, Yukiko Tsuji, Tetsuhiro Ueda, Takuma Nakamura, Toshiki Mizuno, Masahiro Makino Tags: Case Report Source Type: research
Recombinant tissue plasminogen activator (rTPA) management for first onset acute Ischemic Stroke with covid -19 and non-covid -19 patients
In this study we compare the efficacy and safety of Tissue plasminogen activator (rTPA) in acute ischemic stroke (AIS) patients with or without Covid-19 infection.
Source: Journal of Stroke and Cerebrovascular Diseases - January 22, 2023 Category: Neurology Authors: Eman M Khedr, Ahmed Abdelwarith, Gehad M Moussa, Mostafa Saber Source Type: research
Left atrial appendage thrombus in acute stroke: diagnostic accuracy of CT angiography compared to transesophageal echocardiography
To evaluate the value of an extended emergency computed tomography angiography (CTA) including cardiac imaging in patients with acute ischemic stroke for the detection of left atrial appendage (LAA) thrombus compared to transesophageal echocardiography (TEE) as a reference standard.
Source: Journal of Stroke and Cerebrovascular Diseases - December 13, 2022 Category: Neurology Authors: Jo ão Pinho, Laurien Dhaenens, Jan Heckelmann, Manuel Dafotakis, Rebecca May, Martin Wiesmann, Jörg Bernhard Schulz, Oliver Matz Source Type: research
