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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Thrombosis
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Total 415 results found since Jan 2013.
Recurrent Cerebral Venous Thrombosis Treated with Direct Oral Anticoagulants in a Japanese Man with Hereditary Protein C Deficiency
We herein report a case involving a 32-year-old Japanese man with recurrent cerebral venous thrombosis due to hereditary protein C deficiency. He was admitted to our hospital with impaired consciousness. Brain magnetic resonance imaging demonstrated high intensities diffusely along the bilateral sulci and magnetic resonance venography revealed left transverse sinus and superior sagittal sinus stenoses. His father had a history of cerebral infarction and venous thrombosis. The protein C activity level examined by chromogenic synthetic substrate assay was markedly reduced.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Kazuyuki Saito, Kazuyuki Ishii, Konosuke Furuta, Masaki Kobayashi, Yoshiaki Wada, Eriko Morishita Tags: Case Report Source Type: research
Covid-19 and major organ thromboembolism: manifestations in neurovascular and cardiovascular systems.
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause multisystemic damage. We undertook a systematic literature review and comprehensive analysis of a total of 55 articles on arterial and venous thromboembolism in COVID-19 and articles on previous pandemics with respect to thromboembolism and compared the similarities and differences between them. The presence of thrombosis in multiple organ systems points to thromboembolism being an integral component in the pathogenesis of this disease.
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2020 Category: Neurology Authors: Presaad Pillai, Joyce Pauline Joseph, Nurul Huda Mohamad Fadzillah, Masliza Mahmod Tags: Review Article Source Type: research
Cerebral Venous Sinus Thromboses in Patients with SARS-CoV-2 Infection: Three Cases and a Review of the Literature
: Early studies suggest that acute cerebrovascular events may be common in patients with coronavirus disease 2019 (COVID-19) and may be associated with a high mortality rate. Most cerebrovascular events described have been ischemic strokes, but both intracerebral hemorrhage and rarely cerebral venous sinus thrombosis (CVST) have also been reported. The diagnosis of CVST can be elusive, with wide-ranging and nonspecific presenting symptoms that can include headache or altered sensorium alone.
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2020 Category: Neurology Authors: Felix Nwajei, Pria Anand, Mohamad Abdalkader, Vanesa C. Andreu Arasa, Hugo J. Aparicio, Siavash Behbahani, Gioacchino Curiale, Ali Daneshmand, Hormuzdiyar Dasenbrock, Thomas Mayo, Asim Mian, Thanh Nguyen, Charlene Ong, J. Rafael Romero, Osamu Sakai, Court Source Type: research
Acute Spinal Cord Infarction with Preferential Involvement of Ventral Gray Matter: An Autopsy Report
Herein, we report abdominal aortic thrombosis as a rare cause of acute spinal cord infarction. A 78-year-old man with multiple vascular risk factors developed acute paraplegia with sensory and urinary disturbances and signs of ischemia in both lower limbs. The post-mortem study done 3 days after the onset of symptoms revealed a large coagulum in the abdominal aorta, distal to the renal arteries and extending to bilateral common iliac arteries; in addition, marked atherosclerosis was present in most large blood vessels.
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2020 Category: Neurology Authors: Shuta Toru, Tetsuo Yamada, Masako Suzuki, Akira Takemoto, Tomonari Amano, Masanobu Kitagawa, Takayoshi Kobayashi, Toshiki Uchihara Tags: Case Report Source Type: research
Mean Platelet Volume/Platelet Count Ratio is Associated with Poor Clinical Outcome After Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is both a hypercoagulable and inflammation state in which many biomarkers have been studied. Activated platelets have been identified to be of clinical importance in thrombosis and neuroinflammation after aSAH. The aim of this study was to investigate the relationship between mean platelet volume (MPV) to platelet count (PC) ratio, a surrogate parameter for activated platelets, and the functional outcome in aSAH patients.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2020 Category: Neurology Authors: Zhigang Wang, Wen Pei, Lvan Chen, Yuemin Ning, Yong Luo Source Type: research
Bilateral Internal Carotid Artery Agenesis and Posterior Circulation Stroke: A Rare Association
We report the clinical presentation, imaging findings and management of a unique case of a 25 year old man having bilateral internal carotid agenesis with cerebellar ischemic lesions secondary to thrombus formation in dolichoectatic basilar artery.
Source: Journal of Stroke and Cerebrovascular Diseases - October 8, 2020 Category: Neurology Authors: Suresh Giragani, Komal Kumar RN, Ashok Reddy Kasireddy, Surender Alwala Tags: Case Report Source Type: research
Cerebral venous thrombosis in patients with COVID-19 infection: a case series and systematic review
: There has been increasing reports associating the coronavirus disease 2019 (COVID-19) with thromboembolic phenomenon including ischemic strokes and venous thromboembolism. Cerebral venous thrombosis (CVT) is a rare neurovascular emergency that has been observed in some COVID-19 patients, yet much remains to be learnt of its underlying pathophysiology.
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2020 Category: Neurology Authors: Tian Ming Tu, Claire Goh, Ying Kiat Tan, Aloysius ST Leow, Yu Zhi Pang, Jaime Chien, Humaira Shafi, Bernard PL Chan, Andrew Hui, Jasmine Koh, Benjamin YQ Tan, N. Thirugnanam Umapathi, Leonard LL Yeo Source Type: research
Left Atrial Spinning Ball Thrombus in a Patient with Cardioembolic Stroke: A Case Report
Left atrial thrombi are found in 2.5 –18% of patients with atrial fibrillation and are the main cause of thromboembolic events.1 Abe et al advocated the classification of left atrial thrombi into three types; movable ball type, fixed ball type and mountain type, and demonstrated that the rate of embolism in the movable type group wa s significantly higher than that in the other groups.2,3 However, there is no previous report that specifically describes what kind of movement has a poor prognosis in movable left atrial thrombi.
Source: Journal of Stroke and Cerebrovascular Diseases - October 3, 2020 Category: Neurology Authors: Akira Machida, Yasuhito Kawana, Itsuki Soejima, Takeshi Bo, Eiichiro Amano Tags: Case Report Source Type: research
Patterns of Care and Clinical Outcomes in Patients with Cerebral Sinus Venous Thrombosis
Cerebral venous sinus thrombosis (CVST) is a rare type of stroke, occurring in an estimated 13 –15 people per million per year.1, 2 Middle-aged adults, primarily women, are the most affected.3 Prognosis is generally good, but an estimated 15–20% of patients may experience poor outcomes.4 While the diagnosis, treatment and prognosis of CVST has been the focus of current research,5, 6 patte rns of care for these patients has been largely ignored.
Source: Journal of Stroke and Cerebrovascular Diseases - September 26, 2020 Category: Neurology Authors: Andrea Holcombe, Nicholas Mohr, Mudassir Farooqui, Sudeepta Dandapat, Biyue Dai, Cynthia B. Zevallos, Darko Quispe-Orozco, Fazeel Siddiqui, Santiago Ortega-Gutierrez Source Type: research
Characteristics of a Diverse Cohort of Stroke Patients with SARS-CoV-2 and Outcome by Sex
Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), usually presents as a respiratory illness. Neurological manifestations can be seen in 36.4% of patients.1 Patients with vascular risk factors (VRFs), including history of stroke, tend to have worse prognosis.2 COVID-19 triggers a robust inflammatory response which leads to hypercoagulability and thromboembolism.3 Reports of stroke in patients with COVID-19 are mostly limited to small case series or case reports of ischemic stroke (IS), though intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) have also been reported.
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2020 Category: Neurology Authors: G. Trifan, F.D. Goldenberg, F.C. Caprio, J. Biller, M. Schneck, A. Khaja, T. Terna, J. Brorson, C. Lazaridis, Z. Bulwa, R. Alvarado-Dyer, F.G. Saleh-Velez, S. Prabhakaran, E.M. Liotta, A. Batra, N.J. Reish, S. Ruland, M. Teitcher, W. Taylor, P. De la Pena Source Type: research
Clinical Features of CVT in Women and Effect on Subsequent Pregnancy: A Follow-Up Study in a Chinese National Comprehensive Hospital
Cerebral venous thrombosis (CVT) is a relatively rare subtype of ischemic cerebrovascular disease, accounting for only 0.5% –1.0% of all strokes1 and occurring more commonly in young women. The International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) reported that 78% of CVT patients were younger than 50 years old and 75% were female.2 This significant gender difference may be due to many gender-specific risk factors, such as pregnancy, puerperium, and oral contraceptives. In pregnancy and puerperium, changes in hemodynamics and sex hormone levels could cause a hypercoagulable state in the body.
Source: Journal of Stroke and Cerebrovascular Diseases - September 5, 2020 Category: Neurology Authors: Ya-Ting Wu, Li-Xin Zhou, Ming Yao, Jun Ni, Yi-Cheng Zhu, Li-Ying Cui, Bin Peng Source Type: research
Thrombolysis Following Central Venous Catheter Placement
Since the importance of time in the treatment of hyperacute ischemic stroke became widely known, the frequency of thrombolysis has been gradually increasing.1,2 As thrombolytic agents are infusion formulations, securing a venous access route is mandatory.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2020 Category: Neurology Authors: Kenichi Sakuta, Ryoji Nakada, Shinji Miyagawa, Izumu Hasegawa, Hiroshi Yaguchi Tags: Case Report Source Type: research
Clinical Trial Based Rationale for the Successful Use of DOAC in the Treatment of Cerebral Venous Sinus Thrombosis (CVST): A Case Report
In cerebral venous sinus thrombosis (CVST), venous sinus occlusion increases venous pressure and disrupts venous return, resulting in progression to venous infarction and venous hemorrhage, with poor neurologic outcome. Therefore, early recanalization of the major venous sinus is critical.Anticoagulant therapy with continuous intravenous infusion of heparin and subsequent oral anticoagulant administration is the recommended first line of treatment for CVST. Some large clinical trials for venous thromboembolism (VTE) have shown that direct oral anticoagulant (DOAC) is non-inferior to the standard therapy with heparin or war...
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2020 Category: Neurology Authors: Toshiaki Bando, Yasushi Ueno, Daisuke Shimo, Takahiro Kuroyama, Kazuyuki Mikami, Shinya Hori, Osamu Hirai Tags: Case Report Source Type: research
Spontaneous Epidural Hematomas due to Cerebral Venous Thrombosis in a Patient with Immune Thrombocytopenic Purpura
Intracerebral haemorrhage in patients suffering from cerebral venous thrombosis (CVT) is relatively uncommon. CVT typically occurs in hypercoagulable state of various causes. Some drugs play a causative role in CVT and thrombopoietin receptor agonists are among them.
Source: Journal of Stroke and Cerebrovascular Diseases - August 29, 2020 Category: Neurology Authors: Dimitrios Ntantos, Eleni Karantali, Angeliki Prevezianou, Petros Angelopoulos, Sevasti Bostantjopoulou Tags: Case Report Source Type: research
Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis
The coronavirus disease 2019 (COVID-19) potentially increases the risk of thromboembolism and stroke. Numerous case reports and retrospective cohort studies have been published with mixed characteristics of COVID-19 patients with stroke regarding age, comorbidities, treatment, and outcome. We aimed to depict the frequency and clinical characteristics of COVID-19 patients with stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 28, 2020 Category: Neurology Authors: Mai Yamakawa, Toshiki Kuno, Takahisa Mikami, Hisato Takagi, Gary Gronseth Source Type: research
