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Tossing a coin or using common sense
Abstract Anticoagulation with warfarin is the leading cause for emergency hospitalizations due to adverse drug events in elderly Americans [1]. In one third of those events warfarin alone or in combination with other dugs was identified as the cause. Antiplatelet agents were the third leading cause (13.3%) and thus in half of the cases antithrombotic therapy was implicated as the cause for emergency hospitalization. Fear of bleeding and old age of the patient are among the most common reasons for not prescribing anticoagulant therapy to patients with atrial fibrillation for whom this kind of stroke prophylaxis is indicated...
Source: Journal of Thrombosis and Haemostasis - January 17, 2013 Category: Hematology Authors: S. Schulman Tags: Commentary Source Type: research

Molecular requirements for a safer generation of thrombolytics by bioengineering the tissue plasminogen activator (tPA) A chain
ConclusionsWe designed tPA mutants with molecular properties that, in contrast to tPA, do not induce neurotoxicity.© 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - January 10, 2013 Category: Hematology Authors: J. Parcq, T. Bertrand, A.F. Baron, Y. Hommet, E. Anglès–Cano, D. Vivien Tags: Original Article ‐ Fibrinolysis Source Type: research

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