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Source: Journal of Thrombosis and Haemostasis
Condition: Thrombosis
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Total 137 results found since Jan 2013.
Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study
ConclusionsThese results support the importance of contact activation pathway‐dependent TG as a risk factor for ischemic stroke and indicate the importance of F12 SNPs on TG ex vivo and in vivo.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - August 1, 2015 Category: Hematology Authors: N. C. Olson, S. Butenas, L. A. Lange, E. M. Lange, M. Cushman, N. S. Jenny, J. Walston, J. C. Souto, J. M. Soria, G. Chauhan, S. Debette, W.T. Longstreth, S. Seshadri, A.P. Reiner, R. P. Tracy Tags: Original Article ‐ Coagulation Source Type: research
A Phase II, double‐blind, randomized, parallel group, dose‐finding study of the safety and tolerability of darexaban compared with warfarin in patients with non‐valvular atrial fibrillation: the oral factor Xa inhibitor for prophylaxis of stroke in atrial fibrillation study 2 (OPAL‐2)
ConclusionsIn this Phase II study in patients with NVAF, a lower bleeding rate was observed in the 120 mg daily darexaban group compared with warfarin with a reduction in plasma D‐dimer as marker for hemostasis. Further investigation of the optimal dose of darexaban for the prevention of stroke in patients with NVAF would need to be considered.
Source: Journal of Thrombosis and Haemostasis - July 15, 2015 Category: Hematology Authors: G. Y. H. Lip, J. L. Halperin, P. Petersen, G. M. Rodgers, D. Pall, R. W. Renfurm Tags: Original Article Source Type: research
Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women
ConclusionIn young women, prothrombotic factors are more associated with risk of IS than MI risk, suggesting a different role of hypercoagulability in the mechanism leading to these two diseases.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 14, 2015 Category: Hematology Authors: Bob Siegerink, Alberto Maino, Ale Algra, Frits R Rosendaal Tags: Original Article ‐ Cardiovascular Medicine Source Type: research
Plasma ADAMTS‐13 levels and the risk of myocardial infarction: an individual patient data meta‐analysis
ConclusionsLow ADAMTS‐13 levels are associated with an increased risk of myocardial infarction.
Source: Journal of Thrombosis and Haemostasis - July 14, 2015 Category: Hematology Authors: A. Maino, B. Siegerink, L. A. Lotta, J. T. B. Crawley, S. Cessie, F. W. G. Leebeek, D. A. Lane, G. D. O. Lowe, F. Peyvandi, F. R. Rosendaal Tags: Original Article Source Type: research
New Paradigms in Sepsis: From Prevention to Protection of Failing Microcirculation
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 1, 2015 Category: Hematology Authors: J. Hawiger, R. A Veach, J. Zienkiewicz Tags: Review Article Source Type: research
A Phase II, Double‐Blind, Randomized, Parallel Group, Dose Finding Study of the Safety and Tolerability of Darexaban Compared with Warfarin in Patients with Non‐Valvular Atrial Fibrillation
ConclusionsIn this Phase II study in patients with NVAF, a lower bleeding rate was observed in the 120mg daily dose group of darexaban compared to warfarin and plasma D‐dimer as marker for haemostasis was reduced. Further investigation of the optimal dose of darexaban for the prevention of stroke in patients with NVAF would need to be considered.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2015 Category: Hematology Authors: Gregory YH Lip, Jonathan L Halperin, Palle Petersen, George M Rodgers, Denes Pall, Ronny W Renfurm Tags: Original Article ‐ Cardiovascular Medicine Source Type: research
Plasma ADAMTS13 levels and the risk of myocardial infarction: an individual patient data meta‐analysis
ConclusionLow levels of ADAMTS13 are associated with an increased risk of MI.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2015 Category: Hematology Authors: A. Maino, B. Siegerink, L. A. Lotta, J. T. B. Crawley, S. le Cessie, F. W. G. Leebeek, D. A. Lane, G. D. O. Lowe, F. Peyvandi, F. R. Rosendaal Tags: Original Article ‐ Cardiovascular Medicine Source Type: research
Global Public Awareness of Venous Thromboembolism
ConclusionsOn a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2015 Category: Hematology Authors: Aaron M Wendelboe, Micah McCumber, Elaine M Hylek, Harry Buller, Jeffrey I Weitz, Gary Raskob, Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research
Neutrophil to Lymphocyte Ratio (NLR) and Risk of First Episode Stroke in Patients with Atrial Fibrillation: A Cohort Study
ConclusionsNLR is directly associated with the risk of stroke in patients with atrial fibrillation. Future studies are needed to replicate these findings.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 18, 2015 Category: Hematology Authors: Walid Saliba, Ofra Barnett‐Griness, Mazen Elias, Gad Rennert Tags: Original Article ‐ Cardiovascular Medicine Source Type: research
Factor XI and Contact Activation as Targets for Antithrombotic Therapy
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 1, 2015 Category: Hematology Authors: David Gailani, Charles E. Bane, Andras Gruber Tags: Review Article Source Type: research
Antithrombotic Therapy for Left Ventricular Assist Devices in Adults: a Systematic Review
ConclusionsOf 977 manuscripts, 24 articles met the inclusion criteria of adults with implanted LVADs where clinical outcomes were defined based on anticoagulant and/or antiplatelet regimen. Most studies reported treatment with unfractionated heparin post‐operatively which was transitioned to a vitamin K antagonist (VKA). Goal INR varied between 1.5‐3.5. Antiplatelet regimens ranged from no treatment to dual therapy. Definition of major bleeding differed between trials and incidence varied between 0% and 58%. The available evidence could not demonstrate a clear benefit of aspirin compared with VKA therapy alone [stroke...
Source: Journal of Thrombosis and Haemostasis - April 6, 2015 Category: Hematology Authors: Lisa Baumann Kreuziger, Benjamin Kim, Georg M. Wieselthaler Tags: Review Article Source Type: research
Prevalence and risk factors of retinal vein occlusion: the Gutenberg Health Study
ConclusionsThe prevalence of RVO in this German population was 0.4% and males were 1.7 times more frequently affected than females. CRVO was associated with higher age and a family history of stroke, and BRVO with arterial hypertension and atrial fibrillation.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 1, 2015 Category: Hematology Authors: Katharina A Ponto, Hisham Elbaz, Tunde Peto, Dagmar Laubert‐Reh, Harald Binder, Philipp S Wild, Karl Lackner, Norbert Pfeiffer, Alireza Mirshahi Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research
Risk of ischemic stroke associated with non‐steroidal anti‐inflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients with a high background CV risk.
Source: Journal of Thrombosis and Haemostasis - February 24, 2015 Category: Hematology Authors: P. García‐Poza, F. J. Abajo, M. J. Gil, A. Chacón, V. Bryant, L. A. García‐Rodríguez Tags: Original Article Source Type: research
Anemia predicts thromboembolic events, bleeding complications and mortality in patients with atrial fibrillation: Insights form the RE‐LY trial
ConclusionsAnemia is associated with a raised risk of thromboembolic events, bleeding complications and mortality in anticoagulated patients with AF. These findings suggest that patients with anemia should be monitored closely during all types of anticoagulant treatment.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - February 1, 2015 Category: Hematology Authors: B. Daan Westenbrink, Marco Alings, Stuart J. Connolly, John Eikelboom, Michael D. Ezekowitz, Jonas Oldgren, Sean Yang, Janice Pongue, Salim Yusuf, Lars Wallentin, W.H. Gilst Tags: Original Article ‐ Cardiovascular Medicine Source Type: research
Risk of ischaemic stroke associated with non‐steroidal antiinflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischaemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients at high background CV risk.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 22, 2015 Category: Hematology Authors: Patricia García‐Poza, Francisco J. Abajo, Miguel J. Gil, Ana Chacón, Verónica Bryant, Luis A. García‐Rodríguez Tags: Original Article ‐ Cardiovascular Medicine Source Type: research
