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Heparin bridging in warfarin anticoagulation therapy initiation could increase bleeding in non‐valvular atrial fibrillation patients: a multicenter propensity‐matched analysis
ConclusionsThe heparin‐bridging therapy increased bleeding without the benefit of preventing stroke at the initiation of OAC in NVAF. Our data suggest that heparin bridging should not be considered at the initiation of OAC in NVAF patients.
Source: Journal of Thrombosis and Haemostasis - January 7, 2015 Category: Hematology Authors: T.‐H. Kim, J.‐Y. Kim, H.‐S. Mun, H.‐Y. Lee, Y. H. Roh, J.‐S. Uhm, H.‐N. Pak, M.‐H. Lee, B. Joung Tags: Original Article Source Type: research

Dabigatran adherence in atrial fibrillation patients during the first year after diagnosis: a nationwide cohort study
ConclusionMore than 75% of patients were adherent >80% during the first year. Patients with higher morbidity, including patients with a higher risk of stroke or bleeding, exhibited better adherence. This improvement may be attributable to more regular contact with the health care system.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 1, 2015 Category: Hematology Authors: Anders Gorst‐Rasmussen, Flemming Skjøth, Torben Bjerregaard Larsen, Lars Hvilsted Rasmussen, Gregory Y.H. Lip, Deirdre A. Lane Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Heparin bridging in warfarin anticoagulation therapy initiation could increase bleeding in nonvalvular atrial fibrillation patients: A multicenter propensity‐matched analysis
ConclusionsThe heparin bridging therapy increased bleeding without the benefit of preventing stroke at the initiation of OAC in NVAF. Our data suggest that heparin bridging should not be considered at the initiation of OAC in NVAF patients.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - December 4, 2014 Category: Hematology Authors: Tae‐Hoon Kim, Jong‐Youn Kim, Hee‐Sun Mun, Hye‐Young Lee, Yun Ho Roh, Jae‐Sun Uhm, Hui‐Nam Pak, Moon‐Hyoung Lee, Boyoung Joung Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Thrombosis: a major contributor to the global disease burden
Summary Thrombosis is a common pathology underlying ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2010 documented that ischemic heart disease and stroke collectively caused one in four deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability. We performed a systematic review of the literature on the global disease burden caused by VTE in low‐income, middle‐income and high‐income countries. Studies from western Europe, North America, Australia and southern Latin America (Argentina) yield...
Source: Journal of Thrombosis and Haemostasis - October 9, 2014 Category: Hematology Tags: Review Article Source Type: research

Inflammation Markers and Incident Venous Thromboembolism: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort
ConclusionHigher CRP and lower serum albumin were associated with increased VTE risk, and statistically mediated part of the association of BMI with VTE. These data suggest inflammation may be a potential mechanism underlying the relationship of obesity and VTE risk.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - October 7, 2014 Category: Hematology Authors: Nels C. Olson, Mary Cushman, Pamela L. Lutsey, Leslie A. McClure, Suzanne Judd, Russell P. Tracy, Aaron R. Folsom, Neil A. Zakai Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Monitoring the anticoagulant effect after a massive rivaroxaban overdose
We report the case of a 42‐year‐old man who took an overdose of 1400 mg of rivaroxaban and describe how resolution of the anticoagulant effect was monitored using readily available coagulation assays.
Source: Journal of Thrombosis and Haemostasis - August 11, 2014 Category: Hematology Authors: L.‐A. Linkins, K. Moffat Tags: Case of the Month Source Type: research

Comparing mortality in patients with atrial fibrillation who are receiving a direct‐acting oral anticoagulant or warfarin: a meta‐analysis of randomized trials
ConclusionAs compared with warfarin therapy for stroke prevention in patients with AF, DOACs significantly reduce all‐cause mortality, vascular mortality, and bleeding mortality. This mortality benefit appears to be driven by the reduction in vascular‐related and bleeding‐related mortality, which, in turn, may be related to the reduction in intracranial bleeding.
Source: Journal of Thrombosis and Haemostasis - July 25, 2014 Category: Hematology Authors: A. Liew, M. O'Donnell, J. Douketis Tags: Brief Report Source Type: research

Pneumonia, thrombosis and vascular disease
SummaryAn enhanced risk of cardiovascular mortality has been observed after pneumonia. Epidemiological studies have shown that respiratory tract infections are associated with an increased risk of thrombotic‐related vascular disease such as myocardial infarction, ischemic stroke and venous thrombosis. Myocardial infarction and stroke have been detected essentially in the early phase of the disease (i.e. within 48 h from hospital admission), with an incidence ranging from as low as 1% to as high as 11%. Age, previous cardiovascular events and high pneumonia severity index were independent predictors of myocardial infarct...
Source: Journal of Thrombosis and Haemostasis - July 23, 2014 Category: Hematology Authors: F. Violi, R. Cangemi, C. Calvieri Tags: Review Article Source Type: research

Case Report: Monitoring the Anticoagulant Effect After a Massive Rivaroxaban Overdose
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 1, 2014 Category: Hematology Authors: Lori‐Ann Linkins, Karen Moffat Tags: Case Report Source Type: research

Contraceptive pills and thrombosis : effects of the French crisis on prescriptions and consequences for medicine agencies
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 1, 2014 Category: Hematology Authors: Joseph Emmerich, Camille Thomassin, Mahmoud Zureik Tags: Forum Source Type: research

Circulating desphospho‐uncarboxylated matrix γ‐carboxyglutamate protein and the risk of coronary heart disease and stroke
This study could not confirm that high dp‐ucMGP levels, reflecting poor vitamin K status, are associated with increased CHD or stroke risk in the general population.
Source: Journal of Thrombosis and Haemostasis - June 19, 2014 Category: Hematology Authors: G. W. Dalmeijer, Y. T. Schouw, E. J. Magdeleyns, C. Vermeer, W. M. M. Verschuren, J. M. A. Boer, J. W. J. Beulens Tags: Original Article Source Type: research

D‐dimer and risk of thromboembolic and bleeding events in patients with atrial fibrillation – observations from the ARISTOTLE trial
ConclusionIn anticoagulated patients with AF the level of D‐dimer is related to the risk of stroke, death and bleeding and adds to the predictive value of clinical risk scores. The benefits of apixaban were consistent regardless of the baseline D‐dimer level.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 18, 2014 Category: Hematology Authors: Christina Christersson, Lars Wallentin, Ulrika Andersson, John H Alexander, Jack Ansell, Raffaele Caterina, Bernard J Gersh, Christopher B Granger, Michael Hanna, John D Horowitz, Kurt Huber, Steen Husted, Elaine M Hylek, Renato D Lopes, Agneta Siegbahn Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Improving prediction of recanalization in acute large‐vessel occlusive stroke
ConclusionsAcute endovascular treatment is the single most important factor promoting recanalization in acute ischemic stroke. The presence of extracranial vessel stenosis or occlusion decreases recanalization rates. In patients with intracranial occlusions, higher NIHSS score and ASPECTS and normal vigilance facilitate recanalization. Clinical use of these predictors could influence recanalization strategies in individual patients.
Source: Journal of Thrombosis and Haemostasis - June 10, 2014 Category: Hematology Authors: P. Vanacker, D. Lambrou, A. Eskandari, P. Maeder, R. Meuli, G. Ntaios, P. Michel Tags: Original Article Source Type: research

Associations of pentraxin 3 with cardiovascular disease: the Multi‐Ethnic Study of Atherosclerosis
ConclusionsIn these apparently healthy adults, PTX3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independently of CRP and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP, and may provide additional insights into the development and progression of atherosclerosis.
Source: Journal of Thrombosis and Haemostasis - June 10, 2014 Category: Hematology Authors: N. S. Jenny, R. S. Blumenthal, R. A. Kronmal, J. I. Rotter, D. S. Siscovick, B. M. Psaty Tags: Original Article Source Type: research

Pneumonia, thrombosis and vascular disease.
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2014 Category: Hematology Authors: Francesco Violi, Roberto Cangemi, Camilla Calvieri Tags: Review Article Source Type: research

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