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Source: Journal of Thrombosis and Haemostasis
Condition: Thrombosis
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Total 137 results found since Jan 2013.
The protease ‐activated receptor 4 Ala120Thr variant alters platelet responsiveness to low‐dose thrombin and protease‐activated receptor 4 desensitization, and is blocked by non‐competitive P2Y12 inhibition
ConclusionTheF2RL3 rs773902 SNP alters platelet reactivity to thrombin; the allelic effect requires P2Y12, and is not affected by gender. Ticagrelor blocks the enhanced reactivity of rs773902 A platelets. PAR4 encoded by the rs773902 A allele is relatively resistant to desensitization and may contribute to stroke risk.
Source: Journal of Thrombosis and Haemostasis - November 22, 2018 Category: Hematology Authors: M. J. Whitley,
D. M. Henke,
A. Ghazi,
M. Nieman,
M. Stoller,
L. M. Simon,
E. Chen,
J. Vesci,
M. Holinstat,
S. E. McKenzie,
C. A. Shaw,
L. C. Edelstein,
P. F. Bray Tags: Original Article Source Type: research
Enhanced activity of an ADAMTS ‐13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischemic stroke
Journal of Thrombosis and Haemostasis, EarlyView.
Source: Journal of Thrombosis and Haemostasis - October 25, 2018 Category: Hematology Authors: K. South,
F. Denorme,
I. I. Salles ‐Crawley,
S. F. De Meyer,
D. A. Lane Source Type: research
Preadmission use of Glucocorticoids and Risk of Cardiovascular Events in Patients with Ischemic Stroke
Journal of Thrombosis and Haemostasis,Volume 0, Issue ja, -Not available-.
Source: Journal of Thrombosis and Haemostasis - September 4, 2018 Category: Hematology Authors: Jens Sundb øll
,
Bianka Darvalics
,
Erzsébet Horváth‐Puhó
,
Kasper Adelborg
,
Kristina Laugesen
,
Morten Schmidt
,
Victor W Henderson
,
Henrik Toft Sørensen Source Type: research
Enhanced activity of ADAMTS13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischaemic stroke
Journal of Thrombosis and Haemostasis,Volume 0, Issue ja, -Not available-.
Source: Journal of Thrombosis and Haemostasis - August 28, 2018 Category: Hematology Authors: Kieron South
,
Frederik Denorme
,
Isabelle I. Salles ‐Crawley
,
Simon F. De Meyer
,
David A Lane Source Type: research
Mortality due to bleeding, myocardial infarction and stroke in dialysis patients
Journal of Thrombosis and Haemostasis,Volume 0, Issue ja, -Not available-.
Source: Journal of Thrombosis and Haemostasis - July 31, 2018 Category: Hematology Authors: Gurbey Ocak
,
Marlies Noordzij
,
Maarten B. Rookmaaker
,
Aleix Cases
,
C écile Couchoud
,
James G. Heaf
,
Faiçal Jarraya
,
Johan De Meester
,
Jaap W. Groothoff
,
Bård E. Waldum‐Grevbo
,
Runolfur Palsson
,
Halima Resic
,
Césa Source Type: research
Fibrinolysis: Strategies to enhance the treatment of acute ischemic stroke
Journal of Thrombosis and Haemostasis,Volume 0, Issue ja, -Not available-.
Source: Journal of Thrombosis and Haemostasis - June 28, 2018 Category: Hematology Authors: Sara J. Henderson
,
Jeffrey I. Weitz
,
Paul Y. Kim Source Type: research
Oxidized low ‐density lipoprotein in inflammation‐driven thrombosis
SummaryThrombosis is the defining feature of the most prevalent causes of cardiovascular mortality, such as myocardial infarction, stroke, and pulmonary artery embolism. Although platelet activation and activation of the plasmatic coagulation system are the hallmarks of thrombus formation, inflammatory processes and the cellular responses involved are increasingly being recognized as critical modulators of thrombosis. In the context of many chronic inflammatory diseases that are associated with a high thrombotic risk, oxidized lipoproteins represent a prominent sterile trigger of inflammation. Oxidized low‐density lipopr...
Source: Journal of Thrombosis and Haemostasis - January 24, 2018 Category: Hematology Authors: G. Obermayer, T. Afonyushkin, C. J. Binder Tags: State of the Art ISTH2017 Berlin Source Type: research
Oxidized low density lipoprotein in inflammation ‐driven thrombosis
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 6, 2018 Category: Hematology Authors: Georg Obermayer, Taras Afonyushkin, Christoph J. Binder Tags: State of the Art 2017 Source Type: research
The Association between Idiopathic Thrombocytopenic Purpura and Cardiovascular Disease: a retrospective cohort study
ConclusionThere is an increased risk of developing CVD in patients with ITP and even further increased risk for those patients with ITP who underwent splenectomy.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 3, 2018 Category: Hematology Authors: Joht Singh Chandan, Tom Thomas, Sophie Lee, Tom Marshall, Brian Willis, Krishnarajah Nirantharakumar Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research
Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood ‐brain barrier dysfunction
ConclusionsProCPU is increased in CSF during hyperacute ischemic stroke and are associated with stroke progression and outcome after 3 months, most likely due to BBB dysfunction in the hyperacute phase of ischemic stroke.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - December 1, 2017 Category: Hematology Authors: Joachim C Mertens, Dorien Leenaerts, Raf Brouns, Sebastiaan Engelborghs, Margareta Ieven, Peter P De Deyn, Anne ‐Marie Lambeir, Dirk Hendriks Tags: Brief Report – Fibrinolysis Source Type: research
Associations of activated coagulation factor VII and factor VIIa ‐antithrombin levels with genome‐wide polymorphisms and cardiovascular disease risk
ConclusionsResults support the importance of the F7 and PROCR loci on variation in circulating FVIIa and FVIIa‐AT. Findings suggest FVIIa is a risk factor for ischemic stroke in older adults while higher FVIIa‐AT may reflect mortality risk.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - November 1, 2017 Category: Hematology Authors: N. C Olson, L. M Raffield, L. A Lange, E.M. Lange, W. T Longstreth, G. Chauhan, S. Debette, S. Seshadri, A. P Reiner, R. P Tracy Tags: Original Article ‐ Coagulation Source Type: research
Comorbidity and the increased mortality after hospitalization for stroke: a population ‐based cohort study
ConclusionComorbidity, notably cancer and advanced renal or liver disease, increased one‐year mortality after stroke beyond the combined effects expected from either disease acting alone.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - November 1, 2017 Category: Hematology Authors: P. Corraini, S. K. Sz épligeti, Victor W. Henderson, Anne G. Ording, Erzsébet Horváth‐Puhó, Henrik T. Sørensen Tags: Original Article ‐ Cardiovascular Medicine Source Type: research
Comparison of the Ecarin Chromogenic Assay and Diluted Thrombin Time for Quantification of Dabigatran Concentrations
ConclusionsFor detection of levels below 50 ng/mL both tests have specificities of at least 96%, suggesting that they accurately detect even low levels of drug. Therefore, regardless of whether a chromogenic or clot‐based platform is preferred, the STA‐ECA‐II and dTT are useful tests for measuring dabigatran concentrations. Unfortunately, neither test is licensed by the United States Food and Drug Administration. Although approved in other jurisdictions, the dTT and STA‐ECA‐II are not widely or rapidly available in most hospitals. Therefore, cooperation between regulators and hospitals is urgently needed to rende...
Source: Journal of Thrombosis and Haemostasis - October 4, 2017 Category: Hematology Authors: Iqbal H. Jaffer, Noel Chan, Robin Roberts, James C. Fredenburgh, John W. Eikelboom, Jeffrey I. Weitz Tags: Original Article ‐ Coagulation Source Type: research
Fibrinolysis: from blood to the brain
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - September 19, 2017 Category: Hematology Authors: Robert L. Medcalf Tags: State of the Art 2017 Source Type: research
ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formation
ConclusionsARHGEF10 serves as an important regulator in platelet shape change, spreading and aggregation. Moreover, ARHGEF10 also plays an important role in arterial thrombosis formation.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - August 11, 2017 Category: Hematology Authors: Dai ‐Hua Lu, Chun‐Chieh Hsu, Shiu‐Wen Huang, Huang‐Ju Tu, Tur‐Fu Huang, Houng‐Chi Liou, Hsiao‐Mei Liao, Chia‐Hsiang Chen, Wen‐Mei Fu, Susan Shur‐Fen Gau Tags: Original Article – Platelets Source Type: research
