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Source: Journal of Thrombosis and Haemostasis
Condition: Thrombosis

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Total 137 results found since Jan 2013.

Munc13‐4 mediated secretion is essential for infarct progression but not intracranial haemostasis in acute stroke
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 9, 2013 Category: Hematology Authors: David Stegner, Carsten Deppermann, Peter Kraft, Martina Morowski, Christoph Kleinschnitz, Guido Stoll, Bernhard Nieswandt Tags: Letter ‐ to the Editor Source Type: research

Increased platelet activation in early symptomatic versus asymptomatic carotid stenosis and relationship with microembolic status: Results from the Platelets And Carotid Stenosis (PACS) Study
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 26, 2013 Category: Hematology Authors: JA Kinsella, WO Tobin, S Tierney, TM Feeley, B Egan, DR Collins, T Coughlan, D O'Neill, J Harbison, P Madhavan, DJ Moore, SM O'Neill, MP Colgan, CP Doherty, RP Murphy, M Saqqur, N Moran, G Hamilton, DJH McCabe Tags: Original Article ‐ Platelets Source Type: research

Coagulation factor XIIITyr204Phe gene variant and the risk of ischemic stroke
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 19, 2013 Category: Hematology Authors: Marianne Borges Landau, Marília Sande Renni, Mariano Gustavo Zalis, Nelson Spector, Telma Gadelha Tags: Letter ‐ to the Editor Source Type: research

Adherence to anticoagulant treatment with dabigatran in a real‐world setting
ConclusionIn our clinical practice adherence to the twice‐daily dabigatran regimen was generally good, although 12% of the patients had an inadequate adherence. Routine feedback from the pharmacies could inform the physician to improve the anticoagulant management.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 13, 2013 Category: Hematology Authors: S. Schulman, B. Shortt, M. Robinson, J. W. Eikelboom Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Cardiovascular mortality due to pulmonary embolism in subjects with renal impairment: patients’ comorbidities are crucial
Abstract we read with great interest the paper by Ocak et al. (1). The authors found that the age‐ and sex‐standardized mortality rate (SMR) for pulmonary embolism (PE) was 12.2 (95% CI 10.2‐14.6) times higher in dialysis patients than in the general population. Such SMR was even higher than that of myocardial infarction (MI) (11.0, 95% CI 10.6‐11.4), stroke (8.4 (95% CI 8.0‐8.8), and other cardiovascular disease (8.3, 95% CI 8.0‐8.5) On the one hand, the association between the different grade of impaired renal function and MI received important confirmation (2), and also a recent study from our group conducte...
Source: Journal of Thrombosis and Haemostasis - April 4, 2013 Category: Hematology Authors: Fabio Fabbian, Francesco Dentali, Walter Ageno, Roberto Manfredini Tags: Letter Rebuttal Source Type: research

Phase III studies on novel oral anticoagulants for stroke prevention in atrial fibrillation: a look beyond the excellent results. Reply to a rebuttal
We would like to thank Poller et al for his letter and we are happy to reply to their comments. As mentioned by Poller et al many of us participated in the EAA study and are well aware of the results of that study. Time in therapeutic range (TTR) was in fact much higher and bleeding events much lower than those reported in Phase III studies on novel oral anticoagulants (NOAC). However, the aim of our review was to compare the results of the three randomized studies, two of which were double blind double dummy with both the investigators and patients unaware of the type of treatment. © 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - April 1, 2013 Category: Hematology Authors: V. PENGO, F. MARONGIU, Tags: Letter ‐ Reply to Rebuttal Source Type: research

Reduced prevalence of arterial thrombosis in von Willebrand disease
ConclusionsThis is the first study showing that VWD patients have a reduced prevalence of arterial thrombosis and provides important insights into the role of VWF in the pathogenesis of arterial thrombosis.© 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - March 18, 2013 Category: Hematology Authors: Y V. Sanders, J Eikenboom, E M. Wee, J G. Bom, M H. Cnossen, M E.L. Degenaar‐Dujardin, K Fijnvandraat, P W. Kamphuisen, B A.P. Laros‐ Gorkom, K Meijer, E P. Mauser‐Bunschoten, F W.G. Leebeek, Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Remote ischemic preconditioning reduces thrombus formation in the rat
Ischemic preconditioning (IPC) is known to protect tissue from ischemia and has effect both locally[i] and systemically[ii]. Remote IPC (RIPC) induced by limb ischemia provides systemic protection against prolonged ischemia in the target organ. RIPC has been reported to reduce infarct size in patients with ST‐elevation myocardial infarction (STEMI) undergoing primary angioplasty[iii] and is currently evaluated in patients with ischemic stroke undergoing thrombolysis (NCT00975962). © 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - March 18, 2013 Category: Hematology Authors: DM Røpcke, VE Hjortdal, GE Toft, MO Jensen, SD Kristensen Tags: Letter ‐ to the Editor Source Type: research

Predicting post‐thrombolysis intracerebral hemorrhage: A systematic review
Abstract ObjectivesFear of intracerebral hemorrhage (ICH) is a deterrent to the uptake of thrombolytic therapy, an evidence‐based treatment for acute ischemic stroke. Several characteristics associated with post‐thrombolysis ICH have been identified, but their combined utility for risk stratification has yet to be clarified. We critically examined risk models to predict post‐thrombolysis ICH, and evaluated their potential clinical utility. MethodsMEDLINE (Inception to October 2012) was searched and bibliographies of retrieved articles examined. Inclusion and exclusion criteria of each study were reviewed. Eligible st...
Source: Journal of Thrombosis and Haemostasis - March 7, 2013 Category: Hematology Authors: J B. Echouffo‐Tcheugui, M Woodward, A P Kengne Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Recommendations for thromboprophylaxis in the 2012 focused update of the ESC guidelines on atrial fibrillation: A commentary
The objective of this article is to provide a commentary on the recommendations for stroke prevention from the 2012 focused update of the European Society of Cardiology guidelines on the management of atrial fibrillation and the evidence (or lack of it) supporting these recommendations. These guidelines strongly advocate a major clinical practice shift towards initially focusing on the identification of ‘truly low risk’ patients who do not need any antithrombotic therapy. After this initial decision‐making step, effective stroke prevention – that is, oral anticoagulation therapy (whether as well controlled adjusted...
Source: Journal of Thrombosis and Haemostasis - March 2, 2013 Category: Hematology Authors: Gregory Y H Lip Tags: Review Article Source Type: research

Upper limb arterial thromboembolism: A systematic review on incidence, risk factors, and prognosis including a meta‐analysis of risk‐modifying drugs
ConclusionsAge, female sex, AF, hypertension, diabetes, myocardial infarction, heart failure and stroke are most common risk factors for thromboembolectomy of the upper limb. The availability of NOAC holds promise in reducing the risk of systemic thromboembolism, but specific data are still limited.© 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - February 25, 2013 Category: Hematology Authors: L V. Andersen, G Y.H. Lip, J S. Lindholt, L Frost Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Phase III studies on novel oral anticoagulants for stroke prevention in atrial fibrillation: a look beyond the excellent results: a rebuttal
New oral anticoagulant drugs (NOACs) have been made available for the treatment of thrombo‐embolism. Pengo et al. [1] reviewed the results of three such new agents approved by various authorities for stroke prevention in atrial fibrillation (AF). The three new NOACs were evaluated in multicentre comparisons of ”stroke” prevention in patients with AF against the established vitamin‐K antagonist (VKA) warfarin, in three US phase lll studies. © 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - February 11, 2013 Category: Hematology Authors: L. Poller, J. Jespersen, S. Ibrahim, A. Pattison, Tags: Letter ‐ Rebuttal Source Type: research

The impact of atherosclerotic vascular disease in predicting stroke, thromboembolism and mortality in atrial fibrillation patients: A systematic review
ConclusionAtherosclerotic vascular disease (eg. peripheral arterial disease, complex aortic plaque and prior MI) are significant predictors of stroke, thromboembolism and mortality in subjects with AF.© 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - February 1, 2013 Category: Hematology Authors: Branavan Anandasundaram, Deirdre Lane, Stavros Apostolakis, Gregory Y H Lip Tags: Original Article ‐ Vascular Biology Source Type: research

Which Test to Measure the Anticoagulant Effect of Rivaroxaban: The Prothrombin Time Test
Rivaroxaban, administered without dose‐adjustment based on laboratory testing, proved effective and safe for the prevention and treatment of venous thromboembolism and for the prevention of stroke or systemic embolism in atrial fibrillation [1]. However, accumulating evidence suggests that some sort of laboratory measurement may be useful to guide clinicians in special situations including patients on treatment presenting to emergency departments with hemorrhagic or thrombotic events; screening to ensure that the drug has been removed from circulation prior to surgery or invasive procedures; patients with chronic renal i...
Source: Journal of Thrombosis and Haemostasis - February 1, 2013 Category: Hematology Authors: Armando Tripodi Tags: Debate Source Type: research

Severe stroke: patient profile and predictors of favorable outcome
Conclusions:  Severe stroke presentation is predicted by multiple clinical, radiologic and metabolic variables, several of which are modifiable. Predictors in the 28% of patients with favorable outcome despite presenting with severe stroke include hypolipemic pretreatment, lower acute temperature, lower glucose levels at 24 h, and arterial recanalization.
Source: Journal of Thrombosis and Haemostasis - January 27, 2013 Category: Hematology Authors: O. BILL, P. ZUFFEREY, M. FAOUZI, P. MICHEL Tags: ORIGINAL ARTICLE Source Type: research