Molecular requirements for a safer generation of thrombolytics by bioengineering the tissue plasminogen activator (tPA) A chain

ConclusionsWe designed tPA mutants with molecular properties that, in contrast to tPA, do not induce neurotoxicity.© 2013 International Society on Thrombosis and Haemostasis

Source: Journal of Thrombosis and Haemostasis - January 10, 2013 Category: Hematology Authors: J. Parcq, T. Bertrand, A.F. Baron, Y. Hommet, E. Anglès–Cano, D. Vivien Tags: Original Article ‐ Fibrinolysis Source Type: research